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Composite membrane for treatment of skin vasculitis complicated with stage II skin ulceration

A skin ulcer and composite film technology, applied in the field of medical devices, can solve problems such as insufficient strength and limitations, and achieve the effects of preventing infection, promoting wound healing, antibacterial and anti-inflammatory infection

Inactive Publication Date: 2019-04-26
科丝曼(广州)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Chitosan has an antibacterial function, but the biofilm made solely of chitosan is limited in application due to insufficient strength; gelatin has good gelling and film-forming properties; cellulose acetate film is easy to process and non-toxic , with excellent elasticity, air permeability and liquid adsorption

Method used

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  • Composite membrane for treatment of skin vasculitis complicated with stage II skin ulceration

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Experimental program
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Effect test

Embodiment 1

[0026] The invention provides a composite film for treating cutaneous vasculitis complicated by stage II skin ulceration. The composite eye film is prepared from cellulose acetate, chitosan and gelatin. The preparation process includes the following steps:

[0027] (1) prepare Pulsatilla cellulose;

[0028] (2) preparing red head cellulose acetate;

[0029] (3) preparing Pulsatilla cellulose acetate and chitosan composite film;

[0030] (4) Soak the composite film prepared in step (3) in gelatin solution, take it out and dry it.

[0031] The preparation method of the Pulsatilla cellulose is as follows: take the whole herb of Pulsatilla vulgaris, wash and dry it, crush it, and pass it through a 100-mesh sieve, weigh 100 g of the sieve, add 500 mL of 0.5% sulfuric acid to soak for 10 hours, and filter out the sulfuric acid After the solution was washed with water until it became neutral, it was placed in a steam explosion device for steam explosion under the condition that the...

Embodiment 2

[0036] The invention provides a composite film for treating cutaneous vasculitis complicated by stage II skin ulceration. The composite eye film is prepared from cellulose acetate, chitosan and gelatin. The preparation process includes the following steps:

[0037] (1) prepare Pulsatilla cellulose;

[0038] (2) preparing red head cellulose acetate;

[0039] (3) preparing Pulsatilla cellulose acetate and chitosan composite film;

[0040] (4) Soak the composite film prepared in step (3) in gelatin solution, take it out and dry it.

[0041] The preparation method of the Pulsatilla cellulose is as follows: take the whole herb of Pulsatilla vulgaris, wash and dry it, crush it and pass it through a 100-mesh sieve, weigh 100 g of Psyllium vulgaris and sieve it, add 1000 mL of 0.5% sulfuric acid to soak for 10 hours, filter out the sulfuric acid After the solution was washed with water until it became neutral, it was placed in a steam explosion device for steam explosion under the c...

Embodiment 3

[0046] The invention provides a composite film for treating cutaneous vasculitis complicated by stage II skin ulceration. The composite eye film is prepared from cellulose acetate, chitosan and gelatin. The preparation process includes the following steps:

[0047] (1) prepare Pulsatilla cellulose;

[0048] (2) preparing red head cellulose acetate;

[0049] (3) preparing Pulsatilla cellulose acetate and chitosan composite film;

[0050] (4) Soak the composite film prepared in step (3) in gelatin solution, take it out and dry it.

[0051] The preparation method of the Pulsatilla cellulose is as follows: take the whole herb of Pulsatilla vulgaris, wash and dry it, crush it, and pass it through a 100-mesh sieve, weigh 100 g of the sieve, add 1500 mL of 0.5% sulfuric acid to soak for 10 hours, and filter out the sulfuric acid After the solution was washed with water until it became neutral, it was placed in a steam explosion device for steam explosion under the condition that th...

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Abstract

The invention discloses a composite membrane for treatment of skin vasculitis complicated with stage II skin ulceration. The composite membrane is prepared from pararuellia delavayana cellulose acetate, chitosan and gelatin; the preparation method includes steps of taking the pararuellia delavayana medical herbs to prepare pararuellia delavayana cellulose by steam explosion; preparing the pararuellia delavayana cellulose acetate from the pararuellia delavayana cellulose; putting the pararuellia delavayana cellulose acetate into chitosan solution, stirring well and pouring into a mold to dry the solvent to obtain the composite membrane; immersing the composite membrane in a gelatin solution, and then taking out and drying the composite membrane, thus obtaining the composite membrane for treatment of skin vasculitis complicated with stage II skin ulceration. The composite membrane has effects of being antisepsis and anti-inflammation, and promoting wound healing; the composite membrane also can absorb secreta on the surface of the wound, has good biocompatibility and can be used for treatment of skin vasculitis complicated with stage II skin ulceration.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a composite film for treating cutaneous vasculitis complicated by stage II skin ulceration. The composite film is prepared from cellulose acetate, chitosan, and gelatin. It has antibacterial, anti-inflammatory, and wound healing effects. It can absorb wound secretions and has good biocompatibility. It can be used to treat cutaneous vasculitis complicated by Stage II skin ulceration. Background technique [0002] Ruelliadrymophila (Diels) Hand.-Mazz. is a kind of traditional Chinese medicine. The whole herb is used as medicine. It is Ruelliadrymophila (Diels) Hand.-Mazz.), which can clear away heat and detoxify, reduce swelling and relieve pain. External use can cure fractures and cuts Infection, sore abscess. [0003] Chitosan is obtained by deacetylation of chitin, has good biocompatibility, can be biodegraded, and has antibacterial and anti-inflammatory effects. Gelatin is a n...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/38A61K47/36A61K47/42A61P17/02
CPCA61K9/7007A61K47/36A61K47/38A61K47/42A61P17/02
Inventor 于洪斌李悦杜彩华
Owner 科丝曼(广州)有限公司
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