A mitophagy regulator that relieves oxidative stress in pigs

Abstract

The invention discloses a mitophagy regulator for relieving pig oxidative stress, which comprises the following components: 6-13 parts by weight of butyrate, 1-3 parts by weight of Achyranthes knuckle polysaccharide, 5-10 parts by weight of betaine, sodium-based 30-60 parts by weight of montmorillonite. Compared with the addition of butyrate, achyranthes bidentata polysaccharide, betaine and sodium montmorillonite alone in the feed, the present invention can significantly reduce the production of reactive oxygen species in the mitochondria of the liver and intestinal tract and the content of peroxidation product malondialdehyde, and promote oxidation stress. The expression of mitophagy marker proteins PINK1, Parkin, and LC3II / LC3I in pig liver and intestine after stimulation significantly increased the content of mitochondrial DNA and the activity of mitochondrial oxidative respiratory chain complex IV in pig liver and intestine. Moreover, Na-based montmorillonite has a controlled-release effect on butyrate, Achyranthes bidentata polysaccharide, and betaine, making it easy to mix with feed, forming a uniform dispersion system, and easy to use. Through the synergistic effect of each component, the invention significantly improves the level of pig mitophagy, protects the function of mitochondria, and then significantly relieves the oxidative stress of pigs.

Description

technical field [0001] The invention relates to a mitophagy regulator for alleviating pig oxidative stress. Background technique [0002] In pig production, many factors will lead to a large number of free radicals in pigs, such as feed mycotoxin pollution, high temperature, virus infection, weaning, etc.; The balance of the oxidative defense system is disrupted, causing oxidative stress in the body. Oxidative stress can lead to reduced animal immunity, decreased production performance, poor product quality, and even death, resulting in serious economic losses. [0003] The oxidative stress that occurs in the breeding process of livestock and poultry often leads to a decrease in the feed conversion rate of livestock and poultry, a decline in production performance, and serious fat loss during long-distance transportation and waiting for slaughter. growth arrest etc. Among the adverse reactions caused by oxidative stress to livestock and poultry, the impact on production p...

AI Technical Summary

Problems solved by technology

[0004] Antioxidants such as chitosan oligosaccharides and tea polyphenols, which are widely used in animal husbandry production, have antioxidative effects by regulating the activity of antioxidant enzymes to remove excessive ROS. However, relying solely on direct removal of ROS cannot fundamentally Repair oxidative damage, and cannot sustainably relieve the pathological state caused by oxidative stress

The latest research has found that oxidative stress in pigs can lead to damage to mitochondrial function, and an increase in the level of mitophagy has been observed, but the compensatory mitophagy caused by oxidative stress is not enough to repair the body damage caused by oxidative stress. So far, there has been no report on alleviating oxidative stress in pigs by regulating mitophagy

However, mitophagy is also a double-edged sword. Excessive or disordered mitophagy can lead to excessive degradation of mitochondria in cells, causing cellular energy metabolism disorders, and even cell death.