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Preparation method for p-chlorobenzaldehyde

A technology of p-chlorobenzaldehyde and p-chlorotoluene, which is applied to the preparation of halogenated hydrocarbons, chemical instruments and methods, and hydrolysis to prepare carbonyl compounds, etc., can solve the problems of large amount of hydrolysis wastewater, low selectivity, and high cost, and reduce waste water. The total amount, high reaction selectivity, and the effect of improving selectivity

Active Publication Date: 2019-04-19
烟台舜康生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0020] 1. The substitution reaction conditions are harsh and the selectivity is low;
[0021] 2. The yield of hydrolysis reaction is low and the cost is high;
[0022] 3. The amount of hydrolyzed wastewater is large and the treatment is difficult

Method used

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  • Preparation method for p-chlorobenzaldehyde
  • Preparation method for p-chlorobenzaldehyde
  • Preparation method for p-chlorobenzaldehyde

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] Substitution reaction:

[0068] Drop into the p-chlorotoluene of content 99.2% in the dry 500ml four-necked flask that has stirring paddle, chlorine gas pipe, nitrogen gas pipe, reflux condenser (condenser emptying port is connected to tail gas absorption device): 220.0g (1.7252mol ), Bromine: 2.5g. The outer wall of the four-necked flask was heated with heat transfer oil, and the temperature of the heat transfer oil was set at 90°C. Start stirring, turn on nitrogen, and feed 0.5 l / min nitrogen into the four-necked flask for protection. When the temperature of the heat transfer oil reaches 85°C, feed 0.5l / min chlorine gas into the four-necked flask to control the inner temperature of the four-necked flask to 85-90°C (pull out the nitrogen tube, measure the inner temperature with a thermometer, and control the temperature by adjusting the temperature of the heat transfer oil. internal temperature) for a substitution reaction. During the reaction process, the progress ...

Embodiment 2

[0078] Substitution reaction:

[0079] Drop into the p-chlorotoluene of content 99.2% in the dry 500ml four-necked flask that has stirring paddle, chlorine gas pipe, nitrogen gas pipe, reflux condenser (condenser emptying port is connected to tail gas absorption device): 220.2g (1.7268mol ), Bromine: 3.5g. The outer wall of the four-necked flask was heated with heat transfer oil, and the temperature of the heat transfer oil was set at 90°C. Start stirring, turn on nitrogen, and feed 0.5 l / min nitrogen into the four-necked flask for protection. When the temperature of the heat transfer oil reaches 85°C, feed 0.5l / min chlorine gas into the four-necked flask to control the inner temperature of the four-necked flask to 85-90°C (pull out the nitrogen tube, measure the inner temperature with a thermometer, and control the temperature by adjusting the temperature of the heat transfer oil. internal temperature) for a substitution reaction. During the reaction process, the progress ...

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Abstract

The invention discloses a preparation method for p-chlorobenzaldehyde. P-chlorotoluene can be taken as a raw material to perform substitution reaction with chlorine under the action of a catalyst so that a mixture of 4-chlorobenzyl chloride and 4-chloro-1-(dichloromethyl)benzene; and p-chlorobenzaldehyde can be obtained by the mixture of the 4-chlorobenzyl chloride and the 4-chloro-1-(dichloromethyl)benzene under the action of the catalyst through hydrolysis reaction and air catalytic oxidation reaction. Through the action of the catalyst, the reaction temperature of the substitution reactioncan be reduced, and the selectivity of the substitution reaction can be enhanced; the yield of the p-chlorobenzaldehyde can be enhanced by adopting a mode of combining the hydrolysis reaction and aircatalytic oxidation reaction; and the wastewater quantity of the hydrolysis reaction can be reduced through the mode of applying the catalyst.

Description

technical field [0001] The invention relates to the field of fine organic chemical synthesis, in particular to a method for preparing a fine chemical intermediate p-chlorobenzaldehyde. Background technique [0002] p-Chlorobenzaldehyde (4-chlorobenzaldehyde), English name: p-Chlorobenzaldehyde (4-Chlorobenzaldehyde). 4-Chlorobenzaldehyde is an important fine chemical intermediate, which is widely used in pesticides, medicines, dyes and other organic synthesis. In terms of pesticides, it is mainly used to synthesize the fungicide tebuconazole and the insecticide chlorfenapyr. In medicine, it is mainly used in the synthesis of sedatives such as Fenalu. In terms of dyes, it is mainly used in the synthesis of acid brilliant blue 6B and so on. [0003] Taking p-chlorotoluene as a raw material through substitution and hydrolysis to prepare p-chlorobenzaldehyde mainly contains the following three methods: 1. P-chlorotoluene is substituted with chlorine under ultraviolet light to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C45/43C07C47/55C07C17/14C07C25/02
CPCC07C17/14C07C45/43C07C47/55C07C25/02
Inventor 赵乐英
Owner 烟台舜康生物科技有限公司
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