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Biological macromolecule nanosphere containing NADH and preparation method and application thereof

A biopolymer and nanosphere technology is applied in the field of biopolymer nanospheres containing NADH and its preparation, which can solve the problems of unstable chemical properties of NADH, difficult to store, and cannot be taken orally, so as to prolong the storage time, prevent cancer, The effect of reducing the difficulty of saving

Inactive Publication Date: 2019-04-19
HOBOOMLIFE BIO TECH SHENZHEN CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] For this reason, the technical problem to be solved by the present invention is that the chemical properties of NADH are unstable, difficult to store, and cannot be taken orally, thereby proposing a biopolymer nanometer containing NADH that has improved stability, is easy to store, can be taken orally, and can be produced on a large scale. Ball and its preparation method and application

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  • Biological macromolecule nanosphere containing NADH and preparation method and application thereof
  • Biological macromolecule nanosphere containing NADH and preparation method and application thereof
  • Biological macromolecule nanosphere containing NADH and preparation method and application thereof

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Embodiment 1

[0045]This embodiment provides a biopolymer nanosphere containing NADH, which comprises 20 parts of biopolymer carrier and 1 part of NADH in parts by weight. The NADH is dispersed on the biopolymer carrier, and the average weight of the biopolymer carrier is The particle size is 200-1000nm, and the average particle size of the NADH-containing biopolymer nanosphere is 500-1000nm. In the present embodiment, the material of the biopolymer carrier is konjac glucomannan (KGM), and KGM is a natural polymer soluble dietary fiber. The fiber is in a honeycomb three-dimensional interpenetrating network structure, and the mesh size of the network structure is Tens to thousands of nanometers, NADH enters through the mesh and loads on the surface of the KGM fiber network. The biopolymer nano-microspheres also include auxiliary materials, and the auxiliary materials include 0.05 parts of sodium alginate in parts by weight. Sodium alginate is a natural polysaccharide, which has the ability ...

Embodiment 2

[0068] This embodiment provides a biopolymer nanosphere containing NADH, which includes 80 parts of biopolymer carrier and 20 parts of NADH in parts by weight. The NADH is dispersed on the biopolymer carrier, and the average weight of the biopolymer carrier is The particle diameter is 200-1000nm, and the average particle diameter of the biopolymer nanosphere containing NADH is 500-1000nm. In this embodiment, the material of the biopolymer carrier is a mixture of quaternized konjac glucomannan (QKGM) and carboxymethyl konjac glucomannan (CKGM), and the mass ratio of the two is 1:1. Modified KGM is a natural polymer soluble dietary fiber. The fiber has a honeycomb three-dimensional interpenetrating network structure. The mesh size of the network structure is tens to thousands of nanometers. NADH enters through the mesh and is loaded on the surface of the KGM fiber network.

[0069] The biopolymer nanospheres also include auxiliary materials. In this embodiment, the auxiliary mat...

Embodiment 3

[0076]This embodiment provides a biopolymer nanosphere containing NADH, which includes 45 parts of biopolymer carrier and 5 parts of NADH in parts by weight, the NADH is dispersed on the biopolymer carrier, and the average weight of the biopolymer carrier is The particle diameter is 200-1000nm, and the average particle diameter of the biopolymer nanosphere containing NADH is 500-1000nm. In this embodiment, the material of the biopolymer carrier is deacetylated konjac glucomannan (da-KGM), and the above-mentioned modified KGM is a natural polymer soluble dietary fiber, and the fiber has a honeycomb three-dimensional interpenetrating network structure. The mesh size of the network structure is tens to thousands of nanometers, and NADH enters through the mesh and is loaded on the surface of the KGM fiber network.

[0077] The biopolymer nanospheres also include auxiliary materials. In this embodiment, the auxiliary materials include 15 parts by weight of sodium alginate.

[0078...

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Abstract

The invention discloses a biological macromolecule nanosphere containing NADH, which comprises a biological macromolecule carrier and NADH dispersed on the macromolecule carrier. The biological macromolecule carrier is a macromolecule fiber polymer, and the fiber framework of the macromolecule fiber polymer forms a three-dimensional interpenetrating network structure through arrangement modes of disorder arrangement, cross arrangement, crimping arrangement and the like, so that NADH is protected, and the problem that the NADH is easy to decompose when meeting light or oxygen is solved, the storage time of the effective components of the NADH is prolonged and the storage difficulty is reduced. The invention also discloses a preparation process of the nanosphere, which is characterized in that a biological macromolecule material with a moderate chain length is obtained after physical modification, spherical particles are easy to form, a honeycomb-shaped three-dimensional interpenetratingnetwork structure is formed, and NADH small molecules are favorable for being loaded on the inner surface and outer surface of the network structure. The nanospheres can be used for preparing tablets, granules, capsules or soft capsules and other preparations, and can be used as health promoting or pet therapeutic medicine / functional food.

Description

technical field [0001] The invention belongs to the technical field of health care products, and in particular relates to a biopolymer nanosphere containing NADH and a preparation method and application thereof. Background technique [0002] The reduced state of nicotinamide adenine dinucleotide (NADH) is a coenzyme that transfers protons, also known as reduced coenzyme I. In the process of hundreds of metabolic reactions in living cells, NADH acts as an electron donor and has the ability to oxidize Reducing activity plays an important role in electron transfer in processes such as glycolysis, citric acid cycle and photosynthesis. In organisms, NADH is involved in the process of vitamin derivation, the production of adenosine triphosphate (ATP), and is the coenzyme of more than 250 dehydrogenases that have been identified, maintaining cell growth, differentiation and energy metabolism. [0003] NADH is considered to be a substance that has the effect of increasing physical ...

Claims

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Application Information

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IPC IPC(8): A61K9/52A61K9/14A61K31/7084A61K47/36A61P35/00A61P25/16A61P25/28A61P25/24A23L29/30A23L33/10A23L33/26A23P10/20A23P10/28A23P10/30A23P10/35A23P20/25
CPCA23L29/30A23L33/10A23L33/26A23P10/20A23P10/28A23P10/30A23P10/35A23P20/25A23V2002/00A61K9/146A61K9/5161A61K31/7084A61P25/16A61P25/24A61P25/28A61P35/00A23V2200/30A23V2200/10A23V2200/322A23V2250/511A23V2250/5116A23V2250/5042
Inventor 王运陈建生李峰段志刚张波刘喜元方秋杰胡珊叶小舟
Owner HOBOOMLIFE BIO TECH SHENZHEN CO LTD
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