Photoacoustic microscopic imaging device

Abstract

The invention relates to the technical field of microscopic imaging, and discloses a photoacoustic microscopic imaging device, which comprises a translation mounting seat, a cage plate and a Z-axis adjusting mounting seat which are connected by adopting a cage type coaxial system, wherein the translation mounting seat is provided with an optical fiber position adjusting structure which can be adjusted in X, Y and Z directions; a photoacoustic prism clamp is arranged below the Z-axis adjusting mounting seat, the photoacoustic prism clamp is provided with a photoacoustic prism group and an ultrasonic transducer, and the photoacoustic prism clamp is provided with a photoacoustic prism position adjusting structure. According to the photoacoustic microscopic imaging device, the stable cage typecoaxial system is adopted to enable a probe optical element to be installed in a common optical axis, a three-dimensional precision adjusting device is arranged to facilitate adjusting the alignmentand focus of the optical path of the probe, meanwhile,a clamping and adjusting device of the photoacoustic prism is designed, the photoacoustic coaxial confocal adjustment is optimized, the system sensitivity, the imaging resolution and the signal-to-noise ratio are improved, the adjustment is convenient, the experiment efficiency is improved, and the experiment time cost is reduced.

Description

technical field [0001] The invention belongs to the technical field of microscopic imaging, in particular to a photoacoustic coaxial and confocal photoacoustic microscopic imaging device. Background technique [0002] Photoacoustic imaging technology (PAT), its principle is mainly based on the photoacoustic effect, that is, after a substance absorbs modulated light or pulsed light, part of the light energy is converted into heat energy. Due to the thermoelastic effect, the substance expands and periodically expands with heat and contracts with cold. Generate ultrasound. The photoacoustic conversion phenomenon was discovered by American scientist Bell in 1880, and this physical phenomenon was called "photoacoustic effect". It was not until the 1970s that the photoacoustic effect began to be applied in biomedicine. In the 1990s, with the improvement of the solid-state photoacoustic theory and the development of laser and ultrasonic detection technologies, the photoacoustic ef...

AI Technical Summary

Problems solved by technology

Traditional probes lack high-precision adjustable functions, and the photoacoustic coaxial confocal effect is poor, which reduces the detection sensitivity, resolution, and image signal-to-noise ratio of the high-resolution photoacoustic microscopy imaging system; the operation is complicated and time-consuming, increasing The cost of experiment time is reduced; the stability is poor, which has a great impact on the continuity of the continuous monitoring experiment process and the accuracy of the results

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