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Electrochemical sensor for detecting tyramine molecules and preparation method and application thereof

A technology of molecular electrochemistry and sensors, applied in the direction of material electrochemical variables, scientific instruments, nanotechnology for sensing, etc., can solve the problems of poor substrate detection selectivity, etc., and achieve simple preparation process, large application prospects, detection The result is convenient and fast effect

Inactive Publication Date: 2019-04-12
TIANJIN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, graphene is easy to aggregate and accumulate, and graphene-based electrochemical sensors have poor selectivity for substrate detection, which limits its application.

Method used

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  • Electrochemical sensor for detecting tyramine molecules and preparation method and application thereof
  • Electrochemical sensor for detecting tyramine molecules and preparation method and application thereof
  • Electrochemical sensor for detecting tyramine molecules and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] An electrochemical sensor for detecting tyramide molecules is a cyclodextrin-reduced graphene oxide conjugate modified glassy carbon electrode electrochemical sensor, and the electrochemical sensor is dispersed by cyclodextrin-reduced graphene oxide conjugate The droplet is coated on the glassy carbon electrode and dried to obtain a modified electrode, which is used as the working electrode, the Ag / AgCl electrode is used as the reference electrode, and the platinum wire electrode is used as the counter electrode to form an electrochemical sensor; the cyclodextrin- The reduced graphene oxide conjugate is formed by covalently linking ethylenediamine cyclodextrin and graphene oxide and further reducing it with ascorbic acid.

[0039] A preparation method for detecting tyramide molecular electrochemical sensors comprises the following steps:

[0040] (1) Synthesis of cyclodextrin-graphene oxide conjugates

[0041] 1) The synthesis of graphene oxide adopts the improved Humm...

Embodiment 2

[0060] An electrochemical sensor for detecting tyramide molecules is a cyclodextrin-reduced graphene oxide conjugate modified glassy carbon electrode electrochemical sensor, and the electrochemical sensor is dispersed by cyclodextrin-reduced graphene oxide conjugate The droplet is coated on the glassy carbon electrode and dried to obtain a modified electrode, which is used as the working electrode, the Ag / AgCl electrode is used as the reference electrode, and the platinum wire electrode is used as the counter electrode to form an electrochemical sensor; the cyclodextrin- The reduced graphene oxide conjugate is formed by covalently linking ethylenediamine cyclodextrin and graphene oxide and further reducing it with ascorbic acid.

[0061] A preparation method for detecting tyramide molecular electrochemical sensors comprises the following steps:

[0062] (1) Synthesis of cyclodextrin-graphene oxide conjugates

[0063] 1) the synthesis of graphene oxide adopts the improved Humm...

Embodiment 3

[0077] An electrochemical sensor for detecting tyramide molecules is a cyclodextrin-reduced graphene oxide conjugate modified glassy carbon electrode electrochemical sensor, and the electrochemical sensor is dispersed by cyclodextrin-reduced graphene oxide conjugate The droplet is coated on the glassy carbon electrode and dried to obtain a modified electrode, which is used as the working electrode, the Ag / AgCl electrode is used as the reference electrode, and the platinum wire electrode is used as the counter electrode to form an electrochemical sensor; the cyclodextrin- The reduced graphene oxide conjugate is formed by covalently linking ethylenediamine cyclodextrin and graphene oxide and further reducing it with ascorbic acid.

[0078] A preparation method for detecting tyramide molecular electrochemical sensors comprises the following steps:

[0079] (1) Synthesis of cyclodextrin-graphene oxide conjugates

[0080] 1) the synthesis of graphene oxide adopts the improved Humm...

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Abstract

The invention relates to an electrochemical sensor for detecting tyramine molecules and a preparation method and application thereof. The sensor is a cyclodextrin-reduced graphene oxide conjugate modified glassy carbon electrode electrochemical sensor, wherein a cyclodextrin-reduced graphene oxide conjugate is formed in the manners that ethylenediamine cyclodextrin and graphene oxide are connectedthrough a covalent bond, and ascorbic acid is used for reduction; and a modified electrode is formed in the manner that a cyclodextrin-reduced graphene oxide conjugate dispersion droplet is coated ona glassy carbon electrode to be then dried. The electrochemical sensor provided by the invention fully utilizes the superior electron conductivity of graphene and the supramolecular recognition characteristics of cyclodextrin, sensitive electrochemical response signals are generated to the tyramine molecules, electrochemical detection of the tyramine molecules is achieved, and the detection result is convenient, rapid, sensitive and accurate; and the preparation process of the electrochemical sensor is simple, is easy to implement and is low in material cost, and a wide great application prospect in the field of sensitive detection of the tyramine molecules is achieved.

Description

【Technical field】 [0001] The invention relates to the technical field of supramolecular functional materials and electrochemical sensing, in particular to a method for preparing a cyclodextrin / graphene conjugate electrochemical sensor for tyramide molecular detection. 【Background technique】 [0002] Tyramine, namely 4-hydroxyphenylethylamine, is mostly used in food additives and organic synthesis. Thus, tyramine as a parent structure widely exists in alkaloids, amino acids, peptides and synthetic drug molecules. Therefore, it is of vital significance to establish a convenient, rapid, sensitive and accurate detection method for tyramide molecules. Electrochemical sensing analysis method has attracted more and more attention due to its advantages of fast, efficient, accurate and sensitive, simple equipment, and low price. In particular, the application of new functional materials with excellent physical and chemical properties to the construction of electrochemical sensors t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/30G01N27/48B82Y15/00
CPCB82Y15/00G01N27/308G01N27/48
Inventor 赵金朱雪静丛丽蕊李柏橦王瑞瑞郭敏杰
Owner TIANJIN UNIV OF SCI & TECH
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