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Preparation method and application of ferroporphyrin modified mesoporous silica composite material

A technology of mesoporous silica and composite materials, which can be used in chemical instruments and methods, oxidized water/sewage treatment, medical preparations with inactive ingredients, etc., and can solve the problem that catalysts cannot be used as loaded drug delivery systems.

Active Publication Date: 2019-04-05
NANJING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the catalyst prepared by this technical scheme cannot be used as a drug-loaded delivery system

Method used

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  • Preparation method and application of ferroporphyrin modified mesoporous silica composite material
  • Preparation method and application of ferroporphyrin modified mesoporous silica composite material
  • Preparation method and application of ferroporphyrin modified mesoporous silica composite material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1, preparation of porphyrin iron modified mesoporous silica composite material

[0044] The preparation method of the porphyrin iron modified mesoporous silica composite material of the present embodiment comprises the following steps:

[0045] S1. Prepare and obtain SBA-15;

[0046] S2. APTES-SBA-15 was prepared by using SBA-15 prepared in S1;

[0047] S3, take porphyrin iron (FeIX), evenly disperse it in dimethyl sulfoxide (DMSO) solution, add APTES-SBA-15 prepared in S2, keep stirring at constant temperature, centrifuge to remove supernatant, wash and dry, Obtain FeIX-SBA-15, which is porphyrin iron modified mesoporous silica composite material.

[0048] In S3, the specific process of constant temperature and continuous stirring is: 70 ° C ± 5 ° C constant temperature oil bath continuous stirring for 8 ± 1 hours; the specific process of centrifugation is: 5000 ± 500 rpm centrifugation for 5 ± 1 minutes; the washing The specific process is: first wash with wa...

Embodiment 2

[0055] Embodiment 2, preparation load doxorubicin composite material

[0056] The preparation method of this embodiment loaded doxorubicin composite material comprises the following steps:

[0057] T1, using Example 1 to prepare and obtain porphyrin iron modified mesoporous silica composite material, namely FeIX-SBA-15;

[0058] T2. Take doxorubicin hydrochloride (DOX), dissolve it in deionized water and stir evenly to obtain a DOX solution; wherein, the concentration of the DOX solution is 2 ± 1 mg / ml;

[0059] T3. Take the FeIX-SBA-15 obtained in T1, and disperse it into the DOX solution, and keep stirring at a constant temperature; wherein, the specific process of the constant temperature and continuous stirring is: keep stirring in a constant temperature water bath at 37°C±5°C for 24±2 hours ;

[0060] T4. Centrifuge the solution obtained in T3, remove the supernatant, wash and dry, and the resulting product is DOX / FeIX-SBA-15, which is the loaded doxorubicin composite m...

Embodiment 3

[0061] Embodiment 3, scanning electron microscope analysis

[0062] The DOX / FeIX-SBA-15 of SBA-15 and embodiment 2 is done scanning electron microscope analysis, and the result is as follows figure 1 shown.

[0063] It can be seen from the figure that the shape of SBA-15 is regular and short rod-shaped. After modification and loading of DOX, the short rod-shaped regular structure does not change significantly, indicating that the morphology of SBA-15 will not be changed during the preparation of composite materials. .

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Abstract

The invention relates to a preparation method and application of a ferroporphyrin modified mesoporous silica composite material. The preparation method comprises the following steps: preparing SBA-15;preparing APTES-SBA-15; taking ferroporphyrin (FeIX), uniformly dispersing the ferroporphyrin in a dimethyl sulfoxide (DMSO) solution, adding the APTES-SBA-15, continuously stirring at constant temperature to centrifugally remove supernatant, and washing and drying the product to obtain the FeIX-SBA-15, which is the ferroporphyrin modified mesoporous silica composite material. The composite material prepared by the invention can be used for catalytic degradation of industrial dyes and also load anti-tumor drugs, and can increase the drug loading rate and realize slow release of drugs, therebyreducing the acute toxic effect of doxorubicin hydrochloride while maintaining an anti-tumor effect.

Description

technical field [0001] The invention relates to a preparation method and application of a porphyrin iron-modified mesoporous silicon oxide composite material, and belongs to the technical field of catalytic degradation of dyes and drug delivery systems. Background technique [0002] In recent years, mesoporous silica materials have high specific surface area, controllable morphology, regular pore structure, continuously adjustable pore size, and abundant silanol on the surface that can be used as active sites, which is convenient for chemical modification, etc. It shows superior performance in the adsorption, separation and catalytic reaction of macromolecules. Porphyrin iron can catalyze the oxidation of substrates to determine hydrogen peroxide and glucose, and catalyze the degradation of various environmental pollutants such as hydrocarbons and azo dyes. However, due to the easy aggregation of porphyrin iron to produce inactive dimers and low water solubility, its cataly...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J31/16C02F1/72A61K31/704A61K47/24A61P35/00C02F101/30C02F101/38
CPCA61K31/704A61K47/24A61P35/00B01J31/1633C02F1/722C02F1/725C02F2101/308C02F2101/38
Inventor 陈进徐智慧蔡铃陈峰姜慧君宋翌琰
Owner NANJING MEDICAL UNIV
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