Application of carbonic anhydrase inhibitor in the preparation of anti-atherosclerotic drugs

Abstract

The invention belongs to the field of anti-atherosclerosis drugs, in particular to the application of carbonic anhydrase inhibitors in the preparation of anti-atherosclerosis drugs. This study found for the first time that CA1 is highly expressed in atherosclerotic calcified tissue, and CA1 is associated with vascular smooth muscle calcification and affects cell proliferation and apoptosis. Methazolamide, an inhibitor of CA1, can significantly attenuate the process of atherosclerosis and inhibit the inflammatory factors of atherosclerosis. The above results suggest that calcification plays an important role in atherosclerosis, and CA1-dominated calcification promotes the process of atherosclerosis. Methazolamide has potential therapeutic effect on atherosclerosis by inhibiting CA1 expression. These findings not only further illustrate the close relationship between atherosclerosis and calcification, but also explore the calcification mechanism of the disease, and also prove that inhibiting calcification is the key point in the treatment of atherosclerosis. This study provides a new idea for the treatment of this disease.

Description

technical field [0001] The invention relates to the field of anti-atherosclerosis drugs, in particular to the preventive and therapeutic effects of carbonic anhydrase inhibitors, methazolamide and acetazolamide on vascular smooth cell calcification and atherosclerosis. Background technique [0002] Atherosclerosis (AS) is a common vascular system disease characterized by chronic inflammatory response and an important risk factor for cardiovascular disease, mainly involving the intima of large and medium-sized vessels. The damage of vascular endothelial cells is the initial link, followed by massive blood lipid deposition, monocyte aggregation and foam cell formation, vascular endothelial cell dysfunction and smooth muscle cell proliferation, finally leading to atherosclerotic lesions. Vascular calcification is a common pathological manifestation in the process of atherosclerosis, hypertension, diabetes, vascular injury, chronic kidney disease and aging, and is an adaptive pr...

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Problems solved by technology

[0004] Contrary to some laboratories suggesting that CA may play an important role in atherosclerosis, Oksala et al. found that CA2 and CA12 of the CA family are highly expressed in human atherosclerotic plaques, and may be associated with monocyte-derived monocytes in advanced atherosclerosis. It is related to osteoclast-like cells, but the relationship between the expression of CA1 and the mineralization of vascular smooth muscle cells and atherosclerosis has not been reported. It is not clear whether carbonic anhydrase inhibitors have a therapeutic effect on aortic atherosclerosis

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