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Ischemia modified albumin calibrator and application thereof

A calibrator and reagent technology, applied in the field of ischemia-modified albumin calibrator, can solve problems such as difficult promotion and application, cumbersome and complicated preparation steps, etc., and achieve the effects of accurate and reliable detection results, broad application prospects, and cost reduction

Inactive Publication Date: 2019-04-02
AILEX TECH GRP CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the preparation steps of the standard product of this invention are loaded down with trivial details and complicated, are not easy to popularize and apply

Method used

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  • Ischemia modified albumin calibrator and application thereof
  • Ischemia modified albumin calibrator and application thereof
  • Ischemia modified albumin calibrator and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The formula of calibrator level reagent 1 is shown in Table 1:

[0038] Table 1

[0039] raw material name

Content per liter

Sodium azide

1g

Disodium EDTA.2H 2 O

8mM

NaCl

0.9％

Mops

10mM

glycerin

0.05％

[0040] The formula of calibrator level reagent 2 is shown in Table 2:

[0041] Table 2

[0042]

[0043]

Embodiment 2

[0045] The formula of calibrator level reagent 1 is shown in Table 3:

[0046] table 3

[0047] raw material name

Content per liter

Sodium azide

0.8g

Disodium EDTA.2H 2 O

2mM

NaCl

0.7％

Mops

8mM

glycerin

0.04％

[0048] The formula of calibrator level reagent 2 is shown in Table 4:

[0049] Table 4

[0050] raw material name

Embodiment 3

[0052] The formula of calibrator level reagent 1 is shown in Table 5:

[0053] table 5

[0054] raw material name

Content per liter

Sodium azide

1.2g

Disodium EDTA.2H 2 O

10mM

NaCl

1.1％

Mops

12mM

glycerin

0.06％

[0055] The formula of calibrator level reagent 2 is shown in Table 6:

[0056] Table 6

[0057] raw material name

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Abstract

The invention provides an ischemia modified albumin calibrator and application thereof. The calibrator comprises a horizontal reagent 1 and a horizontal reagent 2. Each of the horizontal reagent 1 andthe horizontal reagent 2 is made of raw materials including ethylene diamine tetraacetic acid, sodium azide, sodium chloride and 3-(N-morpholino) propanesulfonic acid. According to the invention, onthe basis of the reaction principle of the ischemia modified albumin, a novel technology is established; the calibrator is prepared by using chelating agents like the EDTA to achieve the objective andthe traditional calibration formula is abandoned; compared with the traditional technology, the novel formula has advantages of high efficiency and stability and simple preparation; and the cost is lowered. Therefore, the ischemia modified albumin calibrator has the broad application prospects and great market value.

Description

technical field [0001] The invention belongs to the field of biotechnology, and relates to an ischemia-modified albumin calibrator and an application thereof. Background technique [0002] Myocardial ischemia refers to a pathological state in which the blood perfusion of the heart is reduced, resulting in a decrease in oxygen supply to the heart, abnormal myocardial energy metabolism, and inability to support the normal work of the heart. During myocardial ischemia, when human serum albumin passes through the ischemic site, the amino acid sequence of serum albumin is destroyed (the amino terminus is modified) due to free radicals, etc., and the albumin whose N-terminus is damaged / occupied by copper is called albumin. It is ischemia-modified albumin (Ischemia-modified albumin, IMA), which is characterized by a decrease in the binding rate of N-terminal and transition metal ions such as cobalt. [0003] Ischemia-modified albumin (IMA) is a new and ideal ischemia marker. It is...

Claims

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Application Information

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IPC IPC(8): G01N33/96
CPCG01N33/96
Inventor 李子樵孙雨佳黄磊
Owner AILEX TECH GRP CO LTD
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