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Stopper capable of preventing formation of traumatic neuroma and preparation method of stopper

An occluder and neuroma technology, applied in medical materials and fields, can solve traumatic neuroma and other problems, and achieve the effect of preventing the formation of traumatic neuroma

Active Publication Date: 2019-04-02
THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Both of the above two invention patents use the nerve cap structure to prevent the formation of neuromas, and the role they play is a physical barrier to reduce the stimulation of related factors near the nerve stump, and does not involve the biological process of axon regeneration. Inhibitory effect, the number and density of newborn axons will not be disturbed, and axon growth and collapse will not occur; and it may be due to the mismatch between the nerve stump and the internal space of the structure, the nerve axons are still inside it Potential for spatial growth, still has chance to form traumatic neuroma

Method used

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  • Stopper capable of preventing formation of traumatic neuroma and preparation method of stopper
  • Stopper capable of preventing formation of traumatic neuroma and preparation method of stopper

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preparation example Construction

[0029] In addition, the present invention also provides the preparation method of above-mentioned occluder, it comprises the following steps:

[0030] S1) dissolving the matrix material of the tubular body with water, and obtaining a tubular body matrix solution after the solution is uniform and transparent; adding an axon regeneration inhibiting substance and a crosslinking agent to the tubular body matrix solution, heating, stirring and crosslinking to obtain a tubular body mixed solution;

[0031] S2) inject the tubular body mixed solution into the mould, and freeze after ultrasonic treatment; wash the mold and the solid tubular body mixed solution with ethanol, and then freeze after ethanol washing; wash the mold and the solid tubular body mixed solution with water, and wash with water Then freeze;

[0032] S3) removing the mold to obtain a formed tubular body;

[0033] S4) Dissolving the matrix material of the filler with water, and obtaining the filler matrix solution a...

Embodiment 1

[0038] The present embodiment provides a kind of preparation method of occluder, it comprises the following steps:

[0039] S1) Dissolve gelatin with deionized water, and prepare a gelatin aqueous solution with a concentration of 0.08 g / ml. After the solution is uniform and transparent, a tubular body matrix solution is obtained; add axon regeneration inhibitor CSPGs and crosslinking agent formaldehyde to the tubular body matrix solution, and the tubular body The concentration of CSPGs in the mixed solution of tubular bodies is 20 μg / ml, and the concentration of formaldehyde in the mixed solution of tubular bodies is 10 mg / ml; stir and cross-link in a water bath at 37°C for 6 hours;

[0040] S2) inject the tubular body mixture into the mold, freeze at -40°C for 1 hour after ultrasonic treatment; wash the mold and the solid tubular body mixture with 98% ethanol, freeze at -40°C for 2 hours after washing with ethanol, repeat this step 3 times; Wash the mold and the solid tubular...

Embodiment 2

[0045] This embodiment provides a method for preparing an occluder, which is different from Embodiment 1 in that: the concentration of the gelatin aqueous solution is 0.04 g / ml, and the concentration of the axon regeneration inhibiting substance in the tubular body mixed solution is 38 μg / ml; The concentration of thermosensitive hydrogel in the substance matrix solution is 130g / ml, the concentration of the axon regeneration inhibitory substance in the filler mixed solution is 50μg / ml, the length of the tubular body is 8mm, the inner diameter is 3mm, and the outer diameter is 4mm.

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Abstract

The invention discloses a stopper capable of preventing formation of traumatic neuroma and a preparation method of the stopper, and belongs to the field of medical materials and technologies. The stopper comprises a pipe-shaped body with a closed end and an opening section; stuffing is stuffed in the pipe-shaped body; axon regeneration inhibition substances are distributed in the pipe-shaped bodyand the stuffing; the substrate materials of the pipe-shaped body and the stuffing are biodegradable biomaterials; and the axon regeneration inhibition substances are at least one of chondroitin sulfate proteoglycan, medullary sheath relevant glycoprotein, oligodendrocyte medullary sheath glycoprotein and Nogo protein. According to the stopper disclosed by the invention, the growth of damaged axons is restrained through combination of physical shielding with medicines having the characteristic of restraining growth, so that neonatal axons are collapsed; and after the stopper is degraded, the tail ends of the axons are enclosed by fibrous connective tissue, so that the purpose of preventing the formation of the traumatic neuroma is achieved.

Description

technical field [0001] The invention belongs to the field of medical materials and technologies, and in particular relates to an occluder for preventing traumatic neuroma formation and a preparation method thereof. Background technique [0002] After peripheral nerve injury, if the damage is severe, or the two ends are too far apart, or there is other soft tissue or scar tissue embedded between the two ends, or the distal end is lost due to amputation, this will cause the new axons to fail to reach the distal end The target organ, while the nearby fibrous connective tissue grows chaotically and forms a tumor-like structure, that is, a traumatic neuroma (Mackinnon SE, Dellon AL, Hudson AR, Hunter DA. Alteration of neuroma formation by manipulation of its microenvironment. Plast Reconstr Surg. 1985, 76(3):345-53.). Traumatic neuromas can cause symptoms such as spontaneous pain, hyperalgesia, or paresthesia in patients, and lead to or aggravate limb dysfunction; 30% of neuroma...

Claims

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Application Information

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IPC IPC(8): A61L29/16A61L29/14A61L29/04
CPCA61L29/043A61L29/046A61L29/048A61L29/14A61L29/145A61L29/16A61L2300/252A61L2300/432A61L2300/602C08L5/08C08L89/00
Inventor 朱庆棠何富林邹剑龙邱帅姚执顾凡彬全大萍刘小林李家春
Owner THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
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