An occluder for preventing the formation of traumatic neuroma and its preparation method
An occluder, neuroma technology, applied in medical materials and fields, can solve problems such as traumatic neuroma, and achieve the effect of preventing traumatic neuroma
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[0029] In addition, the present invention also provides the preparation method of above-mentioned occluder, it comprises the following steps:
[0030] S1) dissolving the matrix material of the tubular body with water, and obtaining a tubular body matrix solution after the solution is uniform and transparent; adding an axon regeneration inhibiting substance and a crosslinking agent to the tubular body matrix solution, heating, stirring and crosslinking to obtain a tubular body mixed solution;
[0031] S2) inject the tubular body mixed solution into the mould, and freeze after ultrasonic treatment; wash the mold and the solid tubular body mixed solution with ethanol, and then freeze after ethanol washing; wash the mold and the solid tubular body mixed solution with water, and wash with water Then freeze;
[0032] S3) removing the mold to obtain a formed tubular body;
[0033] S4) Dissolving the matrix material of the filler with water, and obtaining the filler matrix solution a...
Embodiment 1
[0038] The present embodiment provides a kind of preparation method of occluder, it comprises the following steps:
[0039] S1) Dissolve gelatin with deionized water, and prepare a gelatin aqueous solution with a concentration of 0.08 g / ml. After the solution is uniform and transparent, a tubular body matrix solution is obtained; add axon regeneration inhibitor CSPGs and crosslinking agent formaldehyde to the tubular body matrix solution, and the tubular body The concentration of CSPGs in the mixed solution of tubular bodies is 20 μg / ml, and the concentration of formaldehyde in the mixed solution of tubular bodies is 10 mg / ml; stir and cross-link in a water bath at 37°C for 6 hours;
[0040] S2) inject the tubular body mixture into the mold, freeze at -40°C for 1 hour after ultrasonic treatment; wash the mold and the solid tubular body mixture with 98% ethanol, freeze at -40°C for 2 hours after washing with ethanol, repeat this step 3 times; Wash the mold and the solid tubular...
Embodiment 2
[0045] This embodiment provides a method for preparing an occluder, which is different from Embodiment 1 in that: the concentration of the gelatin aqueous solution is 0.04 g / ml, and the concentration of the axon regeneration inhibiting substance in the tubular body mixed solution is 38 μg / ml; The concentration of thermosensitive hydrogel in the substance matrix solution is 130g / ml, the concentration of the axon regeneration inhibitory substance in the filler mixed solution is 50μg / ml, the length of the tubular body is 8mm, the inner diameter is 3mm, and the outer diameter is 4mm.
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