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Composite silver nano-hydroxyapatite/alginate microspheres and preparation method thereof

A technology of hydroxyapatite and alginate, applied in the field of materials, can solve problems such as high toxicity, achieve good adsorption, strong operability, and no toxic side effects

Pending Publication Date: 2019-03-29
XINYANG NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Silver nitrate has been researched and used as a good antimicrobial property, but if it is used too much, it will cause problems such as greater toxicity, thus limiting its application

Method used

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  • Composite silver nano-hydroxyapatite/alginate microspheres and preparation method thereof
  • Composite silver nano-hydroxyapatite/alginate microspheres and preparation method thereof
  • Composite silver nano-hydroxyapatite/alginate microspheres and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A composite silver nano-hydroxyapatite / alginate microsphere, the microsphere uses hydroxyapatite as the core body, and sodium alginate is fixed in the porous structure of hydroxyapatite, and in the presence of silver ions cross-linked.

[0028] Its preparation method comprises the following steps:

[0029] (1) Sodium alginate was dissolved in ultrapure water at room temperature to prepare a sodium alginate solution with a mass concentration of 1% for subsequent use; silver nitrate was prepared into an aqueous solution of silver nitrate with a molar concentration of 0.75M in the dark Standby; put 0.15g of hydroxyapatite powder in a 50 mL centrifuge tube, add 12 mL of sodium alginate aqueous solution, stir at a high speed of 8000 rpm for 10 minutes at room temperature, and then centrifuge at a speed of 3000 rpm for 3 min at room temperature , the precipitate was washed 3 times with ultrapure water;

[0030] (2) Add 1 mL of silver nitrate aqueous solution to the precipit...

Embodiment 2

[0032] A composite silver nano-hydroxyapatite / alginate microsphere, the microsphere uses hydroxyapatite as the core body, and sodium alginate is fixed in the porous structure of hydroxyapatite, and in the presence of silver ions cross-linked.

[0033] Its preparation method comprises the following steps:

[0034] (1) Sodium alginate was dissolved in ultrapure water at room temperature to prepare a sodium alginate solution with a concentration of 1% for later use, and silver nitrate was prepared into an aqueous solution of silver nitrate with a molar concentration of 0.05M in the dark for later use ;

[0035] Put 0.15 g of hydroxyapatite powder in a 50 mL centrifuge tube, add 18 mL of sodium alginate aqueous solution, stir at a high speed of 15,000 rpm for 10 minutes at room temperature, and then centrifuge at 3,000 rpm for 3 minutes at room temperature. Wash with water 3 times;

[0036] (2) Add 10 mL of silver nitrate aqueous solution to the precipitate obtained in step (1)...

Embodiment 3

[0038] A composite silver nano-hydroxyapatite / alginate microsphere, the microsphere uses hydroxyapatite as the core body, and sodium alginate is fixed in the porous structure of hydroxyapatite, and in the presence of silver ions cross-linked.

[0039] Its preparation method comprises the following steps:

[0040] (1) Sodium alginate was dissolved in ultrapure water at room temperature to prepare a sodium alginate aqueous solution with a concentration of 1.5% for later use, and silver nitrate was prepared into a silver nitrate aqueous solution with a molar concentration of 0.1M for later use in the dark. ;

[0041] Put 0.15 g of hydroxyapatite powder in a 50 mL centrifuge tube, add 9 mL of sodium alginate solution, stir at 20,000 rpm at room temperature for 10 minutes at high speed, then centrifuge at 3,500 rpm at room temperature for 5 minutes, and wash with ultrapure water for 3 times ;

[0042] (2) Add 10 mL of silver nitrate aqueous solution to the precipitate obtained i...

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Abstract

The invention discloses a preparation method of composite silver nano-hydroxyapatite / alginate microspheres. The preparation method of the composite silver nano-hydroxyapatite / alginate microspherescomprises the following steps: (1) dissolving hydroxyapatite powder with an aqueous solution of sodium alginate, carrying out high-speed agitating and then centrifuging, and carrying out washing andprecipitating; and (2) adding a silver nitrate solution into the precipitate, carrying out high-speed agitating and then centrifuging, collecting precipitate, and washing the precipitate so as to obtain the composite silver nano-hydroxyapatite / alginate microspheres. The composite silver nano-hydroxyapatite / alginate microspheres prepared by the preparation method are free of toxic effects on living organisms, and are good in cell compatibility and biodegradability. Moreover, the raw materials are convenient and easy to obtain; the preparation method is simple, convenient and high in operability. Thus, promoted application is facilitated.

Description

technical field [0001] The invention belongs to the technical field of materials, and in particular relates to a composite silver nano-hydroxyapatite / alginate microsphere and a preparation method thereof. Background technique [0002] The template method is used to prepare multifunctional alginate composite silver microspheres. The calcium phosphate material can be used as the core, and the alginate can be fixed in the porous structure of the calcium phosphate material microspheres and cross-linked in the presence of silver ions [RSC Advances, 2016, 24, 20447]. Hydroxyapatite is a non-toxic, non-irritating, high specific surface area, good biocompatibility, high biological activity and stable chemical properties, often used in the preparation of new phosphorus calcium biomaterials [Chinese patent medicine, 2015, 12, 2722]. Sodium alginate is a natural polysaccharide. Natural polysaccharides have good biocompatibility and biodegradability, and are cheap and easy to obtain. ...

Claims

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Application Information

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IPC IPC(8): A61K47/69A61K47/02A61K31/704A61K47/36A61P35/00
CPCA61K31/704A61K47/02A61K47/36A61K47/6949A61P35/00
Inventor 孙萌聂磊张莹莹杨亚男侯孟娟王天文董婧袁红雨
Owner XINYANG NORMAL UNIVERSITY
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