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A drug-loaded blended electrospun fiber membrane and its preparation method

A technology of blending electrospinning and fiber membrane, which is applied in the directions of pharmaceutical formulation, drug combination, drug delivery, etc., can solve the problems of large toxic and side effects, easy inactivation and water solubility of the lactone ring, and achieves the reduction of toxic and side effects and the simple preparation method. Fast, excellent biocompatibility results

Active Publication Date: 2022-04-15
GUANGDONG PROV MEDICAL INSTR INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CPT has many disadvantages, such as high toxicity and side effects, easy inactivation of the lactone ring and poor water solubility, etc.

Method used

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  • A drug-loaded blended electrospun fiber membrane and its preparation method
  • A drug-loaded blended electrospun fiber membrane and its preparation method
  • A drug-loaded blended electrospun fiber membrane and its preparation method

Examples

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Comparison scheme
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Embodiment Construction

[0027] The present invention will be further described below in conjunction with the examples. It should be understood that the following examples are only used to illustrate the present invention and are not intended to limit the protection scope of the present invention.

[0028] Accurately weigh 1000 mg of PLGA (PLA / PGA is 1:1, molecular weight is 44,000) and PF127 with a balance, dissolve it in a mixed solution of dichloromethane and methanol (solution volume ratio is 8:2), and prepare PLGA / PF127 solution with a mass ratio of 4:1, so that the mass concentration of PLGA is 14%, seal the bottle mouth to prevent solvent volatilization, vortex until completely dissolved, and obtain the polymer electrospinning solution. Through electrospinning, adjust the process control parameters of the electrospinning instrument (instrument input voltage 3V, output voltage 10KV): the spinning speed is 0.4mL / min, the receiving distance is 7cm, and the PLGA-PF127 electrospun fiber membrane is ...

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Abstract

The invention discloses a drug-loaded blended electrospun fiber membrane and a preparation method thereof. In the invention, by combining PLGA and PEO as a carrier material and modifying it with PF127, the effective drug concentration can be maintained for a long time, and the enhanced It improves the therapeutic effect, reduces the toxic and side effects, has excellent biocompatibility and degradability, and has broad application prospects. The preparation method is simple, quick and environment-friendly.

Description

technical field [0001] The invention relates to a drug-loaded blended electrospun fiber membrane and a preparation method thereof. Background technique [0002] Tumor is a common and frequently-occurring disease in human life, which seriously threatens the safety of human life. According to data from Cancer Center UK in 2012, there were 14.1 million new cancer cases, of which 8.2 million cancer patients died. Due to the lack of effective treatment, more than 50% of patients die of cancer. At present, the commonly used methods for clinical treatment of tumors include chemotherapy, radiotherapy and surgical resection. Chemotherapy is common and extensive treatment, usually with one or more chemotherapy to relieve symptoms. But if the traditional route is used, chemotherapy drugs have significant side effects on normal healthy cells and tissues. Myelosuppression, mucositis, and alopecia are usually present. A major challenge in chemotherapy is therefore to develop drug del...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K31/4745A61K47/10A61K47/34A61P35/00
CPCA61K47/10A61K47/34A61P35/00A61K9/7007A61K31/4745
Inventor 马盼盼刘群峰顾珩黄德群肖波耿志杰张丽张锦裴大婷
Owner GUANGDONG PROV MEDICAL INSTR INST
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