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Drug-carrying blended electrospinning fiber membrane and preparation method thereof

A technology of blending electrospinning and fiber membrane, which is applied in pharmaceutical formulations, antitumor drugs, drug combinations, etc., can solve the problems of easy inactivation of lactone ring, water solubility, large toxic and side effects, etc., and achieves a simple and fast preparation method and reduces Toxic side effects, promising effects

Active Publication Date: 2019-03-26
GUANGDONG PROV MEDICAL INSTR INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CPT has many disadvantages, such as high toxicity and side effects, easy inactivation of the lactone ring and poor water solubility, etc.

Method used

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  • Drug-carrying blended electrospinning fiber membrane and preparation method thereof
  • Drug-carrying blended electrospinning fiber membrane and preparation method thereof
  • Drug-carrying blended electrospinning fiber membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0027] The present invention will be further described below in conjunction with the examples. It should be understood that the following examples are only used to illustrate the present invention and are not intended to limit the protection scope of the present invention.

[0028] Accurately weigh 1000 mg of PLGA (PLA / PGA is 1:1, molecular weight is 44,000) and PF127 with a balance, dissolve it in a mixed solution of dichloromethane and methanol (solution volume ratio is 8:2), and prepare PLGA / PF127 solution with a mass ratio of 4:1, so that the mass concentration of PLGA is 14%, seal the bottle mouth to prevent solvent volatilization, vortex until completely dissolved, and obtain the polymer electrospinning solution. Through electrospinning, adjust the process control parameters of the electrospinning instrument (instrument input voltage 3V, output voltage 10KV): the spinning speed is 0.4mL / min, the receiving distance is 7cm, and the PLGA-PF127 electrospun fiber membrane is ...

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Abstract

The invention discloses a drug-carrying blended electrospinning fiber membrane and a preparation method thereof. The drug-carrying blended electrospinning fiber membrane and the preparation method thereof disclosed by the invention have the beneficial effects that PLGA (Poly Lactic-co-Glycolic Acid) and PEO (Polyethylene Oxide) are combined as a carrier material and PF127 is used for modification,so that effective drug concentration can be maintained within a longer time, the treatment effect is enhanced and the toxic and side effects are reduced; the drug-carrying blended electrospinning fiber membrane has excellent biological compatibility and degradability, and is wide in application prospect. The preparation method is simple, fast and environment-friendly.

Description

technical field [0001] The invention relates to a drug-loaded blended electrospun fiber membrane and a preparation method thereof. Background technique [0002] Tumor is a common and frequently-occurring disease in human life, which seriously threatens the safety of human life. According to data from Cancer Center UK in 2012, there were 14.1 million new cancer cases, of which 8.2 million cancer patients died. Due to the lack of effective treatment, more than 50% of patients die of cancer. At present, the commonly used methods for clinical treatment of tumors include chemotherapy, radiotherapy and surgical resection. Chemotherapy is common and extensive treatment, usually with one or more chemotherapy to relieve symptoms. But if the traditional route is used, chemotherapy drugs have significant side effects on normal healthy cells and tissues. Myelosuppression, mucositis, and alopecia are usually present. A major challenge in chemotherapy is therefore to develop drug del...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/4745A61K47/10A61K47/34A61P35/00
CPCA61K47/10A61K47/34A61P35/00A61K9/7007A61K31/4745
Inventor 马盼盼刘群峰顾珩黄德群肖波耿志杰张丽张锦裴大婷
Owner GUANGDONG PROV MEDICAL INSTR INST
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