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Cocktail method bi-color freeze-dried powder and preparation method thereof

A technology of freeze-dried powder and cocktail, which is applied in the direction of pharmaceutical formulations, cosmetic preparations, dressing preparations, etc., which can solve the problems of incomplete effects, increased dosage of excipients, poor vision, etc., so that it is not easy to interact, suitable For long-term storage, the effect of long storage time

Active Publication Date: 2019-03-26
广州常青藤化妆品有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The lyophilized powder currently on the market has the following disadvantages: (1) due to the simple added functional ingredients, the effect is not durable; (2) due to the simple added functional ingredients, the effect is not comprehensive; (3) due to the single color of the powder, poor vision
In the actual production of freeze-dried powder, each polypeptide is added as a raw material to the formulation of the freeze-dried powder. Some peptides are pure products, and some are a mixture containing stabilizers. Mix all the raw materials in a The solution will make the formulation and lyophilization process test work complicated and time-consuming and increase the amount of excipients

Method used

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  • Cocktail method bi-color freeze-dried powder and preparation method thereof
  • Cocktail method bi-color freeze-dried powder and preparation method thereof
  • Cocktail method bi-color freeze-dried powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～3

[0031] See Table 1 for the raw material formula of the cocktail method double-color freeze-dried powder described in Examples 1-3, see Table 2 for the raw material formula of excipient A, and see Table 3 for the raw material formula of excipient B.

[0032] The preparation method of the cocktail method double-color freeze-dried powder described in Examples 1-3 comprises the following steps:

[0033] (1), the raw materials of the upper layer freeze-dried powder and the lower layer freeze-dried powder are respectively prepared into an upper layer freeze-dried powder solution and a lower layer freeze-dried powder solution;

[0034] (2), the lower layer of freeze-dried powder solution is first injected into the packaging bottle, and then the upper layer of freeze-dried powder solution is injected into the packaging bottle for freeze-drying treatment:

[0035] a. Lower the temperature to -44°C and keep it for 10 minutes;

[0036] b. Heat up to -35°C within 20 minutes, and keep at ...

Embodiment 4

[0053] The freeze-dried powders prepared in Examples 1-3 and Comparative Example were placed for 0, 6 months and 12 months respectively, dissolved in water, and the time required for complete dissolution was tested. The test results are shown in Table 4.

[0054] The dissolving time of the lyophilized powder that table 4 embodiment 1~3 and comparative example make

[0055]

[0056] As can be seen from the results in Table 4, the freeze-dried powder described in Examples 1 to 3 can still be dissolved in water quickly after being placed for 12 months, while the freeze-dried powder described in Comparative Example needs to be dissolved in water after being placed for 12 months. It takes a long time to completely dissolve, indicating that the formula of the two-color freeze-dried powder of the present invention is more stable and can be stored for a long time.

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Abstract

The invention discloses cocktail method bi-color freeze-dried powder, and further discloses a preparation method of the cocktail method bi-color freeze-dried powder. The cocktail method bi-color freeze-dried powder comprises an upper-layer freeze-dried powder body and a lower-layer freeze-dried powder body; and the upper-layer freeze-dried powder body includes oligopeptide-1, oligopeptide-3 and anexcipient A, and the lower-layer freeze-dried powder body includes tripeptide-1 copper, carnosine and an excipient B, wherein the specific weight of the excipient A is smaller than that of the excipient B. According to the cocktail method bi-color freeze-dried powder, different functional additive components are suitable for being stored in different systems, thus every two systems can be added with more functional additives, the different systems are not prone to acting mutually before the functional additives are freeze-dried, more stability is achieved after freeze-drying, and thus the freeze-dried powder is suitable for being stored for a long term; and during using, the systems are redissolved into one system through a solvent, according to molecular weight distribution of the functional components, cocktail-type step distribution is presented similarly from low to high, micromolecules are absorbed and take effects firstly, macromolecules are absorbed later, step-by-step absorption and relaying effect taking are conducted, and thus the freeze-dried powder takes the effects more quickly and keeps the effects longer.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and in particular relates to a cocktail method double-color freeze-dried powder and a preparation method thereof. Background technique [0002] At present, there are nearly 30 freeze-dried powder manufacturers in China, and their freeze-dried powder products simply add one or two functional ingredients, and the powders are all of a single color (white or colored). The lyophilized powder currently on the market has the following disadvantages: (1) due to the simple added functional components, the effect is not durable; (2) due to the simple added functional components, the effect is not comprehensive; (3) due to the single color of the powder, poor vision . [0003] Polypeptide freeze-dried powder is a new skin care product developed in recent years, which is safe and effective. Its production method can be simply described as: filling the prepared aqueous solution into a vial and other conta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/73A61K8/64A61K8/60A61K8/34A61K8/24A61K8/02A61Q19/00
CPCA61Q19/00A61K8/022A61K8/24A61K8/345A61K8/60A61K8/64A61K8/73A61K8/735A61K2800/84
Inventor 陈同新
Owner 广州常青藤化妆品有限公司
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