A method for the controllable synthesis of cus@epo nanomaterials via electrostatic assembly

A nano-material, EPO-PAH technology, applied in the field of inorganic nano-functional materials, can solve the problems of poor photodynamic therapy effect, inability to use, high temperature requirements, etc., to overcome the dependence on light source, reduce damage, and enhance the effect of treatment

Active Publication Date: 2021-08-27
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Endoperoxide loading on photothermal reagents showed obvious PTT effect, but the effect of PDT treatment was not obvious, photothermal-photodynamic (PTT / PDT) synergistic therapy could not be realized, and singlet oxygen was not detected in the dark
Unable to release singlet oxygen in the dark, unable to achieve the effect of killing cancer cells, naphthalene or anthracene endoperoxide derivatives release singlet oxygen requires too high temperature, can not really be used in living conditions, photodynamic therapy poor effect

Method used

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  • A method for the controllable synthesis of cus@epo nanomaterials via electrostatic assembly
  • A method for the controllable synthesis of cus@epo nanomaterials via electrostatic assembly
  • A method for the controllable synthesis of cus@epo nanomaterials via electrostatic assembly

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Effect test

Embodiment 1

[0021] A method for controllable synthesis of CuS@EPO nanomaterials through electrostatic assembly, comprising the following steps:

[0022] (1) Take sodium citrate and copper chloride dihydrate in a round-bottomed flask filled with deionized water, stir magnetically at room temperature for 15 minutes, then gradually add aqueous solution of sodium sulfide nonahydrate to the above solution, and react at 89 °C After 20 min, an aqueous solution containing nano-CuS was obtained, then cooled, centrifuged, washed, and stored at 4°C; The particle size of CuS is about 20nm, and the concentration of copper chloride dihydrate is 1mol / L;

[0023] (2) After mixing 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide, add the carboxylated pyridone endoperoxidation synthesized in advance The aqueous solution of the product was stirred at 0°C for 1 h to carry out the activation reaction; then the polyallylamine hydrochloride after dehydrochlorination treatmen...

Embodiment 2

[0032] A method for controllable synthesis of CuS@EPO nanomaterials through electrostatic assembly, comprising the following steps:

[0033] (1) Take sodium citrate and copper chloride dihydrate in a round-bottomed flask filled with deionized water. After magnetically stirring at room temperature for 15 minutes, add sodium sulfide nonahydrate solution to the above solution gradually and react at 95°C After 20 min, the aqueous solution containing nano-CuS was obtained, then cooled, centrifuged, washed, and stored at 6 °C; the molar mass of sodium citrate, copper chloride dihydrate, sodium sulfide nonahydrate was 5mol, 6mol:6mol, and the The particle size is about 30nm, and the concentration of copper chloride dihydrate is 1.2mol / L;

[0034] (2) After mixing 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide, add the carboxylated pyridone endoperoxidation synthesized in advance Stir the aqueous solution at 2°C for 1.3h to carry out the activati...

Embodiment 3

[0038] A method for controllable synthesis of CuS@EPO nanomaterials through electrostatic assembly, comprising the following steps:

[0039] (1) Take sodium citrate and copper chloride dihydrate in a round-bottomed flask filled with deionized water, stir magnetically at room temperature for 15 minutes, then gradually add aqueous solution of sodium sulfide nonahydrate to the above solution, and react at 90 °C After 20 min, an aqueous solution containing nano-CuS was obtained, then cooled, centrifuged, washed, and stored at 10°C; The particle size is about 20nm, and the concentration of copper chloride dihydrate is 2mol / L;

[0040] (2) After mixing 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide, add the carboxylated pyridone endoperoxidation synthesized in advance The aqueous solution of the product was stirred at 1°C for 1.2h to carry out the activation reaction; then the polyallylamine hydrochloride after dehydrochlorination treatment was...

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Abstract

The invention provides a method for controllably synthesizing CuS@EPO nanometer materials through electrostatic assembly, and relates to the technical field of inorganic nanometer functional materials. The invention comprises the following steps: (1) mixing sodium citrate, copper chloride dihydrate, and sodium sulfide nonahydrate, reacting at 89-95°C for 20-35 min to obtain nano-CuS; (2) mixing 1-(3- Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and N-hydroxysuccinimide are mixed, then carboxylated pyridone endoperoxide is added to activate the reaction, and polyallylamine hydrochloride is added , mixed evenly and then centrifuged to obtain pyridone endoperoxide-modified polyallylamine hydrochloride; (3) mix pyridone endoperoxide-modified polyallylamine hydrochloride and nano-CuS to obtain pyridone endoperoxide Object-modified CuS@EPO nanomaterials. In the present invention, the nanomedicine itself can still perform PDT treatment without the photothermal effect induced by infrared light, and the photothermal reagent CuS enriched in the tumor site can perform PTT and accelerate the release of singlet oxygen.

Description

technical field [0001] The invention relates to the technical field of inorganic nano-functional materials, in particular to a method for controllably synthesizing CuS@EPO nano-materials through electrostatic assembly. Background technique [0002] Photodynamic therapy is a non-invasive treatment for various tumor diseases. The treatment process includes a photosensitizer, oxygen, and light to construct a photodynamic therapy process and generate singlet oxygen at the tumor site. Singlet oxygen is considered a cytotoxic substance that can interact with nucleic acids, proteins, and DNA and deprive them of their biological activity in photodynamic therapy for cancer treatment. However, the toxic and side effects are small, and the ones without drug resistance seem to have a bright future, but they have great defects. The efficacy of photodynamic therapy for solid tumors is largely limited by a number of issues. Most photodynamic dyes can only be activated by visible light o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K47/58A61P35/00C01G3/12B82Y30/00
CPCA61K41/0042A61K41/0057A61K47/58A61P35/00B82Y30/00C01G3/12C01P2004/64
Inventor 刘见永王治伟丁豪马金良贾潇
Owner FUZHOU UNIV
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