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Preparation method of magnetic nanoparticles, magnetic energy conversion method and application

A magnetic nanoparticle and magnetic technology, which is applied in the application field of preparing biological behavior mediators and/or magnetic energy conversion agents, can solve the problems of changes in material stability, low heat production rate, large amount of magnetic substances used, and the like, To achieve the effect of reduced usage, good prediction and treatment effects, and good control effects

Pending Publication Date: 2019-03-22
CIXI INST OF BIOMEDICAL ENG NINGBO INST OF MATERIALS TECH & ENG CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this application technology is limited due to the large amount of magnetic material used, low heat generation rate, and the stability of the material changes significantly due to temperature changes.

Method used

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  • Preparation method of magnetic nanoparticles, magnetic energy conversion method and application
  • Preparation method of magnetic nanoparticles, magnetic energy conversion method and application
  • Preparation method of magnetic nanoparticles, magnetic energy conversion method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] The preparation of embodiment 1 magnetic nanoparticles

[0074] Weigh 1.352g of ferric chloride hexahydrate and 0.498g of ferrous chloride tetrahydrate and dissolve them in 5mL of water at the same time to obtain an iron salt solution. Take 2mL of the iron salt solution and add it to 170°C and 100mL of diethylene glycol to react for 15min, and then to the reaction Add 50 mL of ammonia water to the system, continue to react for 1 h, wash with ethanol several times, and collect the obtained magnetic cores containing magnetic metal oxides with a neodymium magnet. Mixing the magnetic core, shell material, drug and organic solvent, sonicating for 10s to 60s after 0.5h to 2h, stirring for 5h to 20h, and centrifuging to collect the magnetic nanoparticles after the solvent evaporates;

[0075] denoted as sample 1 # , the sample 1 # Disperse in deionized water and store for later use.

[0076] sample 2 # ~Sample 5 # The preparation operation and sample 1 # The same, but th...

Embodiment 2

[0079] The characterization of embodiment 2 magnetic nanoparticles

[0080] SEM characterization

[0081] The magnetic nanoparticle sample 1 prepared by embodiment 1 # drop on the surface of mica, and perform scanning electron microscope characterization after the sample is dry, such as figure 1 As shown, it can be observed that the magnetic nanoparticles can be uniformly distributed on the mica surface without applying an external magnetic field.

[0082] The magnetic nanoparticle sample 1 prepared by embodiment 1 # Drop it on the surface of mica, and apply a rotating magnetic field of 45mT. After the sample is dry, carry out scanning electron microscope characterization, such as figure 2 As shown, it can be observed that the magnetic nanoparticles present a certain regular distribution on the mica surface, which indirectly proves that the magnetic energy can be converted into the mechanical energy and / or thermal energy of the magnetic composite nanoparticles.

[0083]...

Embodiment 3

[0090] The magnetic energy conversion of embodiment 3 magnetic nanoparticles

[0091] Magnetic energy-mechanical energy conversion

[0092] The sample 1 that embodiment 1 obtains # Co-incubated with A549 cells and carried out multiple groups of controls, the state of the surface of A549 cells under different conditions can be observed, such as Figure 7 with Figure 8 shown. That is, by controlling the magnetic field, the magnetic energy of the magnetic field can be converted into the sample 1 # The mechanical energy in a certain area will generate corresponding tearing force to destroy its cells.

[0093] sample 2 # ~Sample 5 # The magnetic energy-mechanical energy conversion test results and sample 1 # unanimous.

[0094] field-guided transport

[0095] The sample 1 that embodiment 1 obtains # Placed in a movable static magnetic field, moving the static magnetic field, you can observe the sample 1 # Moves with the movement of the static magnetic field. That i...

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Abstract

The invention discloses a preparation method of magnetic nanoparticles. After the magnetic nanoparticles prepared by the preparation method are distributed at specific positions of a living body, magnetic energy can be converted into mechanical energy and / or thermal energy under the action of a magnetic field, thereby stimulating a specific nerve center region or damage a cell structure in the living body, then realizing stimulation of a corresponding nerve center, causing the change in behaviors of the living body or achieving the effect of a malignant tumor by causing damage to cytomembranesand subcellular organelles. By adopting the preparation method, the usage amount of materials is reduced remarkably, the thermal stability of the materials does not need to be considered, a good control effect can be achieved for the active or passive physiological behaviors of numerous living bodies, and good pre-judgment and treatment effects can be achieved for neurogenic diseases. The preparation method comprises the following steps: preparing a magnetic core containing magnetic metal oxide and coating with a polymer layer. The invention further discloses a magnetic energy conversion method and application of the magnetic nanoparticles prepared by the preparation method.

Description

technical field [0001] The present invention relates to the technical field of magnetic energy conversion, in particular to the technology of converting magnetic energy into mechanical energy and / or thermal energy of magnetic nanoparticles, and further relates to its application in the preparation of biological behavior mediators and / or magnetic energy conversion agents. Background technique [0002] With the development of modern economy, the accelerated pace of work and life, and the worsening of the environment, medical experts from all over the world have found that diseases such as depression, schizophrenia, cardiovascular and cerebrovascular diseases, and malignant tumors have become social and economic threats in the 21st century. The common diseases that develop the greatest impact and are most detrimental to personal health and family life. For many years, for the treatment of mental diseases, some sedative, antidepressant, anti-anxiety, hypnotic and other drugs hav...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/51A61K47/32A61P35/00
CPCA61K9/0009A61K9/5138A61K9/5153A61K41/00A61K41/0052Y02A50/30
Inventor 杨方吴爱国李子厚
Owner CIXI INST OF BIOMEDICAL ENG NINGBO INST OF MATERIALS TECH & ENG CHINESE ACAD OF SCI
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