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Application of traditional Chinese medicine composition in preparation of medicine for preventing and/or treating atrophic vaginitis

A technology of atrophic vaginitis and composition, which is applied in the direction of drug combination, plant/algae/fungus/moss components, diseases, etc., can solve the problem that the traditional Chinese medicine formula has not been developed and utilized, and achieve the prevention of atrophic vagina The probability of inflammation, the decrease of bacterial gene abundance, the improvement of safety, and the effect of good safety

Active Publication Date: 2021-12-21
LONGSHUNRONG PHARMA FACTORY TIANJIN ZHONGXIN PHARMA GRP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this traditional Chinese medicine formula has not been fully developed and utilized

Method used

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  • Application of traditional Chinese medicine composition in preparation of medicine for preventing and/or treating atrophic vaginitis
  • Application of traditional Chinese medicine composition in preparation of medicine for preventing and/or treating atrophic vaginitis
  • Application of traditional Chinese medicine composition in preparation of medicine for preventing and/or treating atrophic vaginitis

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Effect test

preparation example Construction

[0065] In a preferred embodiment of the present invention, the preparation method of the traditional Chinese medicine composition includes the following steps: mixing and drying the water extract, alcohol extract and excipient powder to obtain a dry product, wherein the water extract includes honeysuckle, Patrinia, Water extracts of Hedyotis diffusa and Agrimony; Alcoholic extracts include Alcohol extracts of Plantago Seed, Coptidis Rhizoma, Phellodendron Phellodendron, Radix Paeoniae Rubra and Cortex Moutan; Excipient powder includes Alisma powder.

[0066] In a preferred embodiment of the present invention, the preparation method of the traditional Chinese medicine composition includes: Cortex Phellodendri, Honeysuckle, Coptidis Rhizoma, Patrinia, Hedyotis diffusa, Radix Paeoniae Rubra, Moutan Cortex, Agrimony, Plantago and Alisma, the above Shiwei and Alisma are crushed into fine powder, and sieved for later use; Hedyotis diffusa, Agrimony, Honeysuckle, Patrinia are decocted...

Embodiment 1

[0069] Embodiment 1 Chinese medicine composition and preparation

[0070] Phellodendron, honeysuckle, coptis, Patrinia, Hedyotis diffusa, Paeoniae Rubra, Moutan bark, Agrimony, Plantago and Alisma, the above ten flavors, Alisma are crushed into fine powder, sieved for later use; Hedyotis diffusa , agrimony, honeysuckle, Patrinia, decoct twice with water, 1 hour each time, filter, combine the filtrate, and concentrate the filtrate into a clear paste with a relative density of 1.25-1.30 (50°C); the rest of the plantago and other five flavors are used 60% ethanol was heated to reflux three times, for the first time for 3 hours, for the second time for 2 hours, and for the third time for 1 hour, filter, combine the filtrates, recover ethanol, concentrate into a clear paste with a relative density of 1.25-1.30 (50°C). Combine with the above clear paste, add Alisma fine powder and appropriate amount of auxiliary materials, mix well, granulate, dry, and press into 1000 tablets, each ...

Embodiment 2

[0071] Embodiment 2 animal grouping

[0072] According to the dosage design requirements of animal experiments, the preparation method is as follows: the traditional Chinese medicine tablet is crushed by a pulverizer, and the corresponding dosage concentration is prepared by adding purified water.

[0073] High-dose group of traditional Chinese medicine composition: 48 tablets were crushed with purified water, ground, and added with water to make up to 100ml, which was 12 times of clinical human dose.

[0074]The medium dose group of traditional Chinese medicine composition: 24 tablets were crushed with purified water, ground, added with water to make up to 100ml, which was 6 times of clinical human dose (ie equivalent dose).

[0075] Low-dose group of traditional Chinese medicine composition: 12 tablets were crushed with purified water, ground, added with water to make up to 100ml, which was 3 times of the clinical human dose.

[0076] No abnormal reaction was observed durin...

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Abstract

The invention relates to the field of traditional Chinese medicine, in particular, it provides an application of a traditional Chinese medicine composition in the preparation of medicines for preventing and / or treating atrophic vaginitis. The traditional Chinese medicine composition provided by the present invention, raw materials include: Alisma, plantago, Patrinia, honeysuckle, Moutan cortex, Hedyotis diffusa, Radix Paeoniae Rubra, Agrimony, Coptis Rhizoma and Phellodendron Phellodendri, the Chinese medicine composition can be used to prepare The prevention and / or treatment of atrophic vaginitis has remarkable curative effect. The traditional Chinese medicine composition can significantly improve symptoms such as increased vaginal pH, decreased estrogen in blood and urine, decreased microecological diversity, and decreased bacterial gene abundance, and can effectively prevent the body from suffering from atrophic vaginitis. probability, and at the same time, the treatment effect on atrophic vaginitis is also very significant, which fills the gap of lack of effective treatment means for atrophic vaginitis, especially senile vaginitis, and avoids the abuse of antibiotics. The components of the Chinese medicine composition are all Chinese herbal medicines and can be used repeatedly and for a long time.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to the application of a traditional Chinese medicine composition in the preparation of medicines for preventing and / or treating atrophic vaginitis. Background technique [0002] Atrophic vaginitis: With age, the endocrine estrogen in the body begins to decrease. Hormone is a hormone that plays an important role in maintaining the health of the body. The obvious decrease of estrogen will make the inner wall of the vagina dry and less elastic. Vaginal mucous secretions also decrease, and vaginal lubrication decreases causing the entire vagina to shrink (atrophy). Atrophic vaginitis is common in women after natural menopause and ovarian castration, but also in women treated for postpartum amenorrhea or drug pseudomenopause. People with atrophic vaginitis will experience vaginal dryness, tenderness / itching, increased discharge (bloody), recurrent vaginitis, and dyspareunia. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/884A61P15/02
CPCA61P15/02A61K36/355A61K36/65A61K36/68A61K36/71A61K36/718A61K36/73A61K36/748A61K36/756A61K36/84A61K36/884A61K2300/00
Inventor 朱晓丹左辰王蕾李旭王梓王宏吕楠
Owner LONGSHUNRONG PHARMA FACTORY TIANJIN ZHONGXIN PHARMA GRP
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