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Organic and inorganic hybrid composite silver nanoparticle as well as preparation method and application of organic and inorganic hybrid composite silver nanoparticle

A silver nanoparticle and nanoparticle technology, which is applied in the field of organic-inorganic hybrid composite silver nanoparticle and its preparation, can solve the problem that the application research of organic conjugated polymer nanoparticle is rarely reported, and achieve excellent photothermal properties. Performance, excellent photothermal antibacterial effect, simple preparation method

Active Publication Date: 2019-03-19
NANJING UNIV OF POSTS & TELECOMM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, organic conjugated polymer nanoparticles have attracted more and more attention due to their unique optical properties, good photostability and excellent biocompatibility. Target tumor imaging has broad application prospects. Although a lot of work has been done on the biomedical application of this material, the application of organic conjugated polymer nanoparticles in pathogen disinfection has rarely been reported.

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  • Organic and inorganic hybrid composite silver nanoparticle as well as preparation method and application of organic and inorganic hybrid composite silver nanoparticle
  • Organic and inorganic hybrid composite silver nanoparticle as well as preparation method and application of organic and inorganic hybrid composite silver nanoparticle
  • Organic and inorganic hybrid composite silver nanoparticle as well as preparation method and application of organic and inorganic hybrid composite silver nanoparticle

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Effect test

Embodiment 1

[0032] Preparation process and application such as figure 1 Shown, the preparation method of the composite silver nanoparticles of organic-inorganic hybridization is as follows:

[0033] (1) Preparation of conductive polymer (PSBTBT) tetrahydrofuran solution: Weigh 1 mg conductive polymer, add 12 mL tetrahydrofuran and ultrasonically dissolve it completely;

[0034] (2) In the state of ultrasound, quickly inject 2 mL of conductive polymer tetrahydrofuran solution into 10 mL of ultrapure water, and sonicate for 8 min;

[0035] (3) Remove tetrahydrofuran by rotary evaporation, and filter with a 0.22 μm filter head to obtain conductive polymer nanoparticles;

[0036] (4) Add conductive polymer nanoparticle solution (0.08 mg / mL) to Tris-HCl buffer (10 mM, pH=8.5) containing dopamine (0.5 mg / mL), stir at room temperature for 8 h, and centrifuge to purify Three times, the polydopamine-modified conductive polymer nanoparticles were prepared;

[0037] (5) Prepare silver nitrate sol...

Embodiment 2

[0040] Embodiment 2, the in vitro photothermal test of the composite silver nanoparticles of organic-inorganic hybridization:

[0041] The organic-inorganic hybrid composite silver nanoparticle solution (100 μg / mL) in Example 1 was prepared, and ultrapure water was used as a blank control. Put the above-prepared solution in a centrifuge tube, and then use a laser with a wavelength of 635 nm and a power density of 0.5 W / cm 2 Irradiate for 5 min. The result is as image 3 As shown, the test data show that the organic-inorganic hybrid composite silver nanoparticles have excellent photothermal properties.

Embodiment 3

[0042] Embodiment 3, the cytotoxicity test of the composite silver nanoparticles of organic-inorganic hybridization:

[0043] The organic-inorganic hybrid composite silver nanoparticle solutions were prepared into different concentrations (0, 10, 25, 50, 100 μg / mL). HeLa cells were first inoculated on a 96-well plate and incubated for 24 h, then the culture medium in the well was discarded, and materials of different concentrations were added, and the incubation was continued for 24 h, and then incubated for 4 h after adding MTT reagent. The result is as Figure 4 As shown, the test data show that the organic-inorganic hybrid composite silver nanoparticles are almost non-toxic.

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Abstract

The invention discloses an organic and inorganic hybrid composite silver nanoparticle as well as a preparation method and an application of the organic and inorganic hybrid composite silver nanoparticle. The preparation method comprises the steps: firstly, preparing a conductive polymer nanoparticle from a near-infrared conductive polymer by using a re-sedimentation method, then, adding the conductive polymer nanoparticle into a Tris-HCl solution containing dopamine, carrying out stirring for polydopamine modification, carrying out centrifugal purification and reducing silver nitrate by usingglucose to finally form a silver-loaded nanoparticle. The conductive polymer nanoparticle disclosed by the invention has a strong near-infrared adsorption effect so as to have efficient photothermal properties; a polydopamine modification layer not only provides a reduction site of the silver nanoparticle by utilizing abundant functional groups on the surface, but also can further enhance the photothermal properties of the nanoparticle; and the silver nanoparticle has efficient antibacterial property, and the composite silver nanoparticle simultaneously has photothermal antibacterial and silver nanometer antibacterial effects after overcoming the defect of poor stability.

Description

technical field [0001] The invention belongs to the technical field of organic-inorganic hybrid materials. In particular, it relates to an organic-inorganic hybrid composite silver nanoparticle and a preparation method and application thereof. Background technique [0002] Bacteria are closely related to human health. Bacterial infection is an acute systemic infection caused by pathogenic bacteria or opportunistic pathogenic bacteria invading the blood circulation to grow and reproduce, producing toxins and other metabolites. In order to resist such infections, people have paid huge Efforts have been made to develop a variety of antibiotic drugs. However, with the emergence of multiple antibiotic-resistant bacteria, a single treatment method can no longer meet the needs of patients. Therefore, it is urgent to develop new antibacterial materials or enhance antibacterial treatment through synergistic treatments. effect. [0003] Silver nanoparticles (Ag NPs) are an excellent...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/34A61K9/16A61P31/04A61K33/38
CPCA61K9/1641A61K33/38A61K41/0052A61P31/04A61K2300/00
Inventor 鲍碧清汪联辉童丽
Owner NANJING UNIV OF POSTS & TELECOMM
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