Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Sustained-release suspension for endometriosis mouse model building and preparation method

A mouse model and endometrium technology, applied in the biological field, can solve the problems of difficult subcutaneous injection of oil agents, high local irritation, high price, etc., achieve long-lasting slow-release effect, save time, and simple operation

Inactive Publication Date: 2019-03-19
ZHEJIANG UNIV
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Subcutaneous injection of estrogen oil solution can be administered once a week, but oily subcutaneous injection is more difficult and local irritation is great
Slow release of estrogen sustained-release tablets after subcutaneous implantation can maintain a stable blood estrogen concentration, but surgical implantation is required, and the price is expensive (a box of 100 tablets totals US$4,157, and the average single-tablet price is nearly 300 yuan). its application in experimental research

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Sustained-release suspension for endometriosis mouse model building and preparation method
  • Sustained-release suspension for endometriosis mouse model building and preparation method
  • Sustained-release suspension for endometriosis mouse model building and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0027] As a new type of material, thermosensitive hydrogels are gradually being used for drug delivery. The temperature-sensitive hydrogel can change state with the change of temperature. At room temperature, the temperature-sensitive hydrogel is in the state of transparent solution, and the drug can be easily mixed into the solution. As the temperature rises, it can transform into a milky white gel state at about 37 ° C. Drugs are slowly released from it. The degradation products of thermosensitive hydrogel materials are harmless to the human body, and are not easy to cause irritation or other adverse immune reactions in tissues in the body, which provides the possibility for them to be used as subcutaneous drug delivery carriers.

[0028] Further description will be given below in conjunction with the embodiments shown in the accompanying drawings.

[0029] 1. The estrogen temperature-sensitive hydrogel slow-release mixture provided by the present invention takes the temper...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to the field of biology, and aims to provide sustained-release suspension for endometriosis mouse model building and a preparation method of the sustained-release suspension to provide stable, convenient and low-cost exogenous estrogen support for endometriosis mouse model building. The technical scheme includes that the sustained-release suspension for endometriosis mouse model building comprises 0.5-1.0g / ml and the rest thermosensitive hydrogel. The preparation method of the sustained-release suspension for endometriosis mouse model building includes the steps: 1) taking out the thermosensitive hydrogel from a refrigerator; 2) adding estrogen powder into the hydrogel according to the proportion of the estrogen powder and the thermosensitive hydrogel; 3) placing thethermosensitive hydrogel onto an oscillator for oscillation, and sufficiently and uniformly mixing the estrogen powder and the hydrogel to prepare estrogen and thermosensitive hydrogel suspension; 4)placing the suspension into the refrigerator for preservation after sub-packaging.

Description

technical field [0001] The invention relates to the field of biology, in particular to provide stable and convenient exogenous estrogen-supported estrogen temperature-sensitive hydrogel mixture for the establishment of endometriosis mouse models. Background technique [0002] Endometriosis is an important cause of pelvic pain and infertility in women of reproductive age. At present, the pathogenesis of endometriosis is still unclear, and there is a lack of effective treatment. Due to ethical constraints, it is difficult to conduct research on the cause of disease, metabolic changes, drug efficacy, and disease outcome in patients. In vitro animal models address this limitation to some extent. Endometriosis mouse models are widely used in endometriosis-related research. [0003] Endometriosis is an estrogen-dependent disease. The establishment of mouse models of endometriosis plays a fundamental role in the study of the pathogenesis of endometriosis and the development of ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/566
CPCA61K9/0019A61K47/10A61K31/56A01K67/02A01K2207/20A01K2227/105A01K2267/03A61K9/0024A61K47/34A61K49/0008A61K31/566A61P15/00
Inventor 戴永东张松英黄倩梦林翔
Owner ZHEJIANG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com