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Combined immunosuppressive method of anti-CD20 monoclonal antibody and tacrolimus in corneal xenotransplantation

A xenotransplantation, tacrolimus technology, applied in the direction of anti-receptor/cell surface antigen/cell surface determinant immunoglobulin, anti-animal/human immunoglobulin, antibody, etc., can solve the difficult problem of primates. Reproduction, high risk of high sensitivity, high social exclusion

Active Publication Date: 2022-03-15
SEOUL NAT UNIV R&DB FOUND
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  • Claims
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Problems solved by technology

However, primates are endangered species and are difficult to reproduce, so when used as a source of foreign organs, social exclusion is high and there is a high risk of high sensitivity
For this reason, in the progress of many studies, among animals other than primates, pigs were selected as a source of xenogeneic organs, which have organs that are very similar in size to humans, have a shorter 127-day It has the advantages of being easy to reproduce during pregnancy, and can produce many cubs (6 to 12) at one time. However, when the organs of pigs are transplanted into humans, there is a more serious rejection of xenografts compared with allografts ( xenograft rejection) problem

Method used

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  • Combined immunosuppressive method of anti-CD20 monoclonal antibody and tacrolimus in corneal xenotransplantation
  • Combined immunosuppressive method of anti-CD20 monoclonal antibody and tacrolimus in corneal xenotransplantation
  • Combined immunosuppressive method of anti-CD20 monoclonal antibody and tacrolimus in corneal xenotransplantation

Examples

Experimental program
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Embodiment 1

[0034] Example 1: Pig to Primate Xenograft Anti-CD20 Combination Systemic Immunosuppression Protocol

[0035] 1.1 Establishment of a systemic immunosuppressive regimen

[0036] In order to establish a regimen that can suppress the immune response in the preparation of corneas for xenografts, the following anti-CD20 combined systemic immunosuppression regimen was proposed. In this protocol, anti-CD20Ab, anti-IL2RAb, intravenous immunoglobulin (IVIG), tacrolimus, and methylprednisolon were injected according to the prescribed cycle. Rituximab was used as the anti-CD20 mAb and basiliximab was used as the anti-IL2R Ab. The solution of the present invention is figure 1 shown in, as follows.

[0037] Rituximab, an anti-CD20Ab, was injected as an iv slow infusion, 20 mg / kg on the day of the xenograft surgery and on the 7th day after the surgery, and 8 weeks after the surgery, in a cycle of 8 weeks Repeated injections were performed to confirm whether the IgG antibody increased or...

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Abstract

The present invention relates to regimens for suppressing immune rejection that can occur in corneal xenotransplantation. According to the immunoreaction suppression method of the present invention, not only can the grantor effectively suppress the immune rejection caused by the transplanted cornea after full-thickness corneal xenotransplantation, but also can stably maintain the living body transplantation of the cornea for a long time , and can effectively maintain indicators such as corneal thickness and intraocular pressure, so it can be effectively used in heterogeneous corneal transplantation.

Description

technical field [0001] The present invention relates to a regimen for inhibiting immune rejection that can occur during xenografting. Background technique [0002] The cornea (Cornea) is a transparent membrane located on the anterior side of the eyeball wall, accounting for about 1 / 6 of the anterior side of the fibrous wall. When looking at the back side, the cornea is round, and when looking at the front side, the cornea is flat oval. The cornea is the transparent part located at the most anterior side of the eyeball, covering the iris, pupil, and the entire eye chamber, and focuses light precisely on the retina. On the one hand, corneal blindness, which is caused by the loss of the transparency of the cornea, is reported to be a major cause of vision loss. Also, eye trauma and corneal ulcers cause 1.5 to 2 million blindness in patients each year. An effective and only treatment for this kind of blindness is ocular corneal transplantation (also called human corneal trans...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K39/395A61K31/436A61K31/56A61K31/573C07K16/28
CPCA61K31/436A61K31/56A61K31/573A61K39/395C07K16/28A61K39/39566C07K16/2866C07K16/2887A61K2300/00
Inventor 金美昑金在永崔世贤尹昶皓
Owner SEOUL NAT UNIV R&DB FOUND
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