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External capsule preparation for preventing and treating vaginitis

A technology of vaginitis and capsules, applied in the field of biomedicine, to achieve the effects of repairing the vaginal mucosal barrier, enhancing immunity, and accelerating metabolism

Active Publication Date: 2019-03-15
FUJIAN LONGSHENG BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, Lactobacillus live bacteria capsules are available for vaginal use, but at the same time, the repair of vaginal mucosa is also extremely important. A complete mucosal barrier provides a guarantee for preventing the recurrence of vaginitis, but the use of Lactobacillus live bacteria capsules alone cannot meet this demand

Method used

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  • External capsule preparation for preventing and treating vaginitis
  • External capsule preparation for preventing and treating vaginitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Step 1. Weighing: Weigh 1 portion of Lactobacillus plantarum freeze-dried powder according to parts by weight (the number of live Lactobacillus ≥ 1×10 9 CFU), 68 parts of maltodextrin, 30 parts of fructooligosaccharide, 1 part of magnesium stearate;

[0022] Step 2, mixing: the Lactobacillus plantarum freeze-dried powder, maltodextrin, fructooligosaccharides, and magnesium stearate weighed in step 1 are uniformly mixed in equal increments;

[0023] Step 3, capsule filling: take the material mixed in step 2, fill it in gelatin hollow capsules with a capsule filling machine, and the filling dose is 0.25g / capsule, to obtain capsule A;

[0024] Step 4. Weighing: Weigh 75 parts of transdermal EGF freeze-dried powder, 15 parts of transdermal bFGF freeze-dried powder, 5 parts of mannitol, 4 parts of trehalose, and 1 part of magnesium stearate in parts by weight;

[0025] Step 5, mixing: mix the transdermal EGF freeze-dried powder, transdermal bFGF freeze-dried powder, mannito...

Embodiment 2

[0030] Step 1. Weighing: Weigh 1 portion of Lactobacillus plantarum freeze-dried powder according to parts by weight (the number of live Lactobacillus ≥ 1×10 9 CFU), 70 parts of maltodextrin, 27.5 parts of inulin, 1.5 parts of magnesium stearate;

[0031] Step 2, mixing: the Lactobacillus plantarum freeze-dried powder, maltodextrin, inulin, and magnesium stearate weighed in step 1 are uniformly mixed in equal increments;

[0032] Step 3, capsule filling: take the material mixed in step 2, fill it in gelatin hollow capsules with a capsule filling machine, and the filling dose is 0.5g / capsule, to obtain capsule A;

[0033] Step 4. Weighing: Weigh 75 parts of transdermal EGF freeze-dried powder, 15 parts of transdermal bFGF freeze-dried powder, 5 parts of mannitol, 3.5 parts of trehalose, and 1.5 parts of magnesium stearate in parts by weight;

[0034] Step 5, mixing: mix the transdermal EGF freeze-dried powder, transdermal bFGF freeze-dried powder, mannitol, trehalose, and magn...

Embodiment 3

[0039] Step 1. Weighing: Weigh 1 portion of Lactobacillus plantarum freeze-dried powder according to parts by weight (the number of live Lactobacillus ≥ 1×10 9 CFU), 60 parts of maltodextrin, 37 parts of stachyose, 2 parts of magnesium stearate;

[0040] Step 2, mixing: the Lactobacillus plantarum freeze-dried powder, maltodextrin, stachyose, and magnesium stearate weighed in step 1 are uniformly mixed in equal increments;

[0041] Step 3, capsule filling: take the material mixed in step 2, fill it in gelatin hollow capsules with a capsule filling machine, and the filling dose is 1.5g / capsule, to obtain capsule A;

[0042] Step 4, weighing: weigh 75 parts of transdermal EGF freeze-dried powder, 15 parts of transdermal bFGF freeze-dried powder, 5 parts of mannitol, 3 parts of trehalose, and 2 parts of magnesium stearate in parts by weight;

[0043] Step 5, mixing: mix the transdermal EGF freeze-dried powder, transdermal bFGF freeze-dried powder, mannitol, trehalose, and magnes...

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Abstract

The invention discloses an external capsule preparation for preventing and treating vaginitis. The preparation comprises a capsule A and a capsule B, wherein the capsule A is prepared from lactobacillus plantarum ST-III as the main active ingredient, and the capsule B is prepared from main active ingredients of transdermal EGF and transdermal bFGF. In the external capsule preparation, the viable bacteria number of lactobacillus plantarum ST-III is not smaller than 0.25*106 CFU / particle, the transdermal EGF is not less than 1000 ng / particle, and the transdermal bFGF is not less than 200 ng / particle. The external capsule preparation has the functions of enhancing local immunity and repairing vaginal mucosa barrier, and is worthy of wide application in clinical treatment.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to an external capsule preparation for preventing and treating vaginitis. Background technique [0002] Vaginitis is a general term for a variety of vaginal mucosal inflammatory diseases caused by different etiologies. In normal physiological state, the tissue anatomy and biochemical characteristics of the vagina are sufficient to defend against the invasion of external microorganisms. If it is destroyed, pathogenic bacteria can take advantage of the opportunity to enter and cause vaginal inflammation through various factors. Although vaginitis is a common disease in women, it may cause more serious gynecological diseases and even cancer, so vaginitis must not be underestimated. [0003] Vaginitis can be roughly divided into three categories, namely atrophic vaginitis, irritative vaginitis and infectious vaginitis. Vaginitis in menopausal women with estrogen imbal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/18A61K9/48A61P15/02A61P31/04A61K31/047A61K31/702A61K31/733A61K35/747
CPCA61K9/4858A61K31/047A61K31/702A61K31/733A61K35/747A61K38/1808A61K38/1825A61P15/02A61P31/04A61K2300/00
Inventor 林冠雄饶照明曾如意朱海仁
Owner FUJIAN LONGSHENG BIOLOGICAL TECH CO LTD
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