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Application of mesenchymal stem cell exosome to preparation of medicament for preventing and treating radiation-induced lung injury (RILI)

A technology for radiation-induced lung injury and stem cells, applied in the field of stem cell application, can solve the problems of long culture period and restricting clinical application, etc.

Inactive Publication Date: 2019-03-08
中科广聚(北京)生物医学技术中心有限公司 +1
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0003] At present, there is no effective treatment for radiation-induced lung injury in clinical practice. Common treatment methods include oxygen inhalation, cough relief, and asthma relief. For patients with severe RILI, radiotherapy can only be adjusted or stopped. Therefore, the hazards of radiation-induced lung injury have become a bottleneck restricting the application of radiotherapy , Mesenchymal stem cell therapy has achieved a certain therapeutic effect on radiation-induced lung injury in mice. Immunological risks and ethical issues restrict its clinical application; as exosomes from mesenchymal stem cells do not contain genetic material, they avoid a series of problems and become a potential treatment for radiation-induced lung injury

Method used

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  • Application of mesenchymal stem cell exosome to preparation of medicament for preventing and treating radiation-induced lung injury (RILI)
  • Application of mesenchymal stem cell exosome to preparation of medicament for preventing and treating radiation-induced lung injury (RILI)
  • Application of mesenchymal stem cell exosome to preparation of medicament for preventing and treating radiation-induced lung injury (RILI)

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Experimental program
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Embodiment

[0028] 1. Inject 100 mg of exosomes intravenously the next day after radiation exposure, and then detect the indicators.

[0029] Establishment of the mouse model of radiation-induced lung injury: 8-10 week old C57BL / 6 mice were selected, and the entire chest cavity of each mouse was irradiated with 4-6 MV of a linear accelerator, and the head, abdomen and limbs were shielded with lead strips.

[0030] 2. Isolation, culture and identification of mouse bone marrow mesenchyme

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Abstract

The invention discloses application of a mesenchymal stem cell exosome to preparation of a medicament for preventing and treating radiation-induced lung injury (RILI). After a radiated mouse with lunginjury is treated by adopting tail vein injection administration of the mesenchymal stem cell exosome, inflammatory factor level is effectively lowered (IL-1beta, IL-6, TNF-alpha, TGF-beta); the survival rate of the mouse is improved effectively; and pneumonia and lung fibrosis lesion caused by the RILI are reduced. The mesenchymal stem cell exosome has the advantages of high security, stable chemical property and easiness in storage, and a new way is provided for safely and effectively treating the RILI.

Description

technical field [0001] The invention relates to the technical field of stem cell application, in particular to the application of mesenchymal stem cell exosomes in the preparation of drugs for preventing and treating radiation-induced lung injury. Background technique [0002] Radiation therapy (Radiotherapy, radiotherapy) is a treatment method widely used in the treatment of malignant tumors, and has a significant effect on malignant tumors of the chest, such as lung cancer, breast cancer, esophageal cancer, and mediastinal malignant tumors. Radiation-induced lung injury (RILI) usually occurs during radiotherapy. RILI is a serious complication during radiotherapy, mainly manifested as radiation pneumonitis, pulmonary congestion, increased alveolar fibrin exudation or hyaline membrane formation, and finally pulmonary interstitial fibrosis. [0003] At present, there is no effective treatment for radiation-induced lung injury in clinical practice. Common treatment methods in...

Claims

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Application Information

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IPC IPC(8): A61K35/28A61P11/00
CPCA61P11/00A61K9/0019A61K35/28
Inventor 姬广聚杨智广包勇
Owner 中科广聚(北京)生物医学技术中心有限公司
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