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Gynecological qianjin tablet and preparation method thereof

A technology of gynecological Qianjin Tablets and Qianjinba, which is applied in scientific instruments, medical formulas, and medical preparations containing active ingredients, etc., can solve problems such as difficulty in consistency of effects, and achieve good clinical treatment effects, stable drug effect consistency, and The effect of high accuracy

Inactive Publication Date: 2019-02-22
ZHUZHOU QIANJIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among the compatible ingredients of Fuke Qianjin Tablets, Andrographis paniculata is only used as a ministerial drug. Obviously, the existing standards do not stipulate other important ingredients in Qianjin Tablets, which makes it difficult to control the effect of different batches of Fuke Qianjin Tablets. Consistency is difficult

Method used

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  • Gynecological qianjin tablet and preparation method thereof
  • Gynecological qianjin tablet and preparation method thereof
  • Gynecological qianjin tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Example 1 Fuke Qianjin Tablets

[0045] The formula of Fukeqianjin Tablets: Angelica, Codonopsis, Andrographis paniculata and Shuangmianzhen each account for 9% of the total amount of medicinal materials; the dosages of Rosa japonica root, Caulis Spatholobus, Gongluomu and Qianjinba each account for 16% of the total amount of medicinal materials. The total amount of medicinal materials is 500kg. The product is prepared by:

[0046] (1) select Chinese angelica, Codonopsis pilosula, and Andrographis paniculata, grind them into fine powders of more than 100 meshes, and reserve them for later use according to a powder yield of at least 93.3%;

[0047] (2) Select single-faced needle, golden cherry root, Caulis Spatholobus, Gonglaomu and Qianjinba, add water to extract twice, add 10 times the total weight of five-flavored traditional Chinese medicine for the first time, and add 10 times the total weight of five-flavored traditional Chinese medicine for the second time water...

Embodiment 2

[0055] A Fuke Qianjin Tablet, in which steps (1) and (2) are the same as in Example 1 during its preparation process, and the difference from Example 1 is that the content of genistin in each mg of mixture is controlled in step S3 to be no less than 0.00007mg, the content of Z-ligustilide not less than 0.0045mg and / or the content of Z-3-butenylphthalide not less than 0.00011mg, the content of andrographolide and dehydroandrographolide not less than 0.00788 mg; then dried, compressed into tablets, and packaged into tablets to obtain the Fukeqianjin Tablets. According to existing products and production indicators as a reference, the quality of each Fukeqianjin Tablets is 0.32g.

[0056] Fuke Qianjin Tablets were prepared according to the above method, and three batches of products were randomly selected from long-term and large quantities of products, and each batch of Fuke Qianjin Tablets was tested referring to the HPLC detection method in Example 1.

[0057] The HPLC detecti...

Embodiment 3

[0066] Embodiment 3 in vitro drug efficacy test

[0067] Drugs or materials used: croton oil, provided by Nanjing Institute of Dermatology; carrageenan, produced by Japan Wako Pure Chemical Industry Co., Ltd.; nutrient broth medium, product of Guangdong Huankai Microbial Technology Co., Ltd.; mold medium, Provided by the China Institute for the Control of Pharmaceutical and Biological Products.

[0068] The Fukeqianjin Tablets prepared in Example 1 (batch 1 and batch 6) and Comparative Example 1 (batch 1) were used as samples respectively. The clean-grade Kunming mice and SD rats used were all provided by the Hunan Drug Inspection Institute; Escherichia coli ATCC25922, Staphylococcus aureus ATCC25923, and beta-hemolytic streptobacter ATCC32172 were all provided by the Provincial Health and Epidemic Prevention Station. Bacteria were isolated clinically and provided by the Bacteriology Laboratory of the Clinical Laboratory Department of the Third Affiliated Hospital of Hunan Me...

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Abstract

The invention discloses a gynecological qianjin tablet and a preparation method thereof. The gynecological qianjin tablet is prepared from philippine flemingia root, Chinese mahonia stem, andrographispaniculata, zanthoxylum dissitum, suberect spatholobus stem, angelica, codonopsis pilosula and cherokee rose root. Each gynecological qianjin table contains no less than 0.008 mg of genistin and no less than 0.7 mg of Z-ligutilide, and the total amount of andrographolide and dehydroandrographolide is not less than 1.1 mg. According to the preparation method, a new standard for controlling the quality of the gynecological qianjin tablet is established by analyzing chemical components in the gynecological qianjin tablet; the content of multiple core components is added in the standard based onthe existing pharmacopoeia standards; the consistency of the effect between different batches of the gynecological qianjin tablet prepared according to the range is more stable. Compared with the prior art, the gynecological qianjin tablet has a better clinical treatment effect.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, and more specifically, to a Fukeqianjin tablet and a preparation method thereof. Background technique [0002] Fukeqianjin Tablets are medicines made from 8 medicinal materials, including Qianjinba, Rosa Radix, Andrographis paniculata, Gongluomu, Shuangmianzhen, Angelica, Millipede Spatholobus, and Codonopsis pilosula. The effect is to clear heat and dehumidify, tonify qi and blood. It is used for leukorrhea and abdominal pain caused by damp heat and blood stasis. Symptoms include profuse leukorrhagia, thick yellow matter, foul smell, lower abdomen pain, lumbosacral pain, mental fatigue and fatigue; chronic pelvic inflammatory disease, endometritis, Chronic cervicitis see the above syndrome. [0003] In the existing Chinese Pharmacopoeia, for the content identification of Fukeqianjin Tablets, only the total content of andrographolide and dehydroandrographolide is limited, ...

Claims

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Application Information

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IPC IPC(8): A61K36/758A61K9/28A61P15/00A61P29/00G01N30/02
CPCA61K9/28A61K36/19A61K36/232A61K36/29A61K36/344A61K36/48A61K36/486A61K36/738A61K36/758A61K2236/15A61K2236/331A61K2236/39A61K2236/51A61P15/00A61P29/00G01N30/02A61K2300/00
Inventor 江端预彭开锋龚云张鹏伍实花王康华杨秀伟
Owner ZHUZHOU QIANJIN PHARMA
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