A haemocoagulase sublingual film of Agkistrodon lancehead and preparation method thereof

Abstract

The invention discloses a haemocoagulase sublingual membrane and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. The haemocoagulase sublingual film of Agkistrodon lanceolata is prepared from the following raw materials: haemagglutinase from Agkistrodon lanceolata, PVA05-88, PEG-400, hydroxypropyl-β-cyclodextrin borneol inclusion compound and purified water. The preparation method includes: adding PVA05‑88 to purified water, stirring it with magnetic force to disperse evenly and fully swell it, wait for it to cool to room temperature, and set aside; add the remaining raw materials to the above solution in turn, stir well, and let stand to remove air bubbles , apply a film with a thickness of 40 to 60 μm on a film coating machine, and dry it at room temperature at 25°C in a ventilated and cool place to obtain the sublingual film of Agkistrodon haemocoagulase. The invention has the following advantages: it can be quickly absorbed by the oral mucosa to achieve the purpose of rapid onset of effect; oral administration does not require water, and is especially suitable as a first-aid hemostatic drug carried by individual soldiers.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a Agkistrodon haematocoagulase sublingual film and a preparation method thereof. Background technique [0002] Hemocoagulase BothropsAtrox is a hemostatic drug that can be widely used in various medical situations that require bleeding reduction or hemostasis, such as bleeding and bleeding disorders in various clinical departments; it can also be used to prevent bleeding, such as preoperative medication, Can avoid or reduce surgical site and postoperative bleeding. [0003] At present, the hemocoagulase of Agkistrodon haemorrhoids used clinically is freeze-dried powder injection. Based on the clinically good hemostatic effect of Haemocoagulase for Injection, it was selected as a medical emergency drug for rapid hemostasis in the battlefield. However, as an injection, under the special conditions of flight combat and airborne combat missions, comb...

AI Technical Summary

Problems solved by technology

However, as an injection, under the special conditions of flight combat and airborne combat missions, combatants may not be able to use it by themselves, which will affect the first aid and operational capabilities of the wounded.

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