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Gel and preparation method and application thereof

A gel and hydrogel technology, applied in the field of medicine, can solve problems such as inability to achieve long-term beauty, cumbersome preparation process, and inconspicuous therapeutic effect, achieve good organic polymer compatibility, improve nutritional metabolism, The effect of excellent water solubility

Active Publication Date: 2019-02-12
广州远想生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The patent with application number 200810009190.8 discloses a suspension of hyaluronic acid or its salt containing macromolecular hydrogel and its preparation method, but its macromolecules are cross-linked polysaccharide compounds or polymers of a single component. The effect is not obvious, and hyaluronic acid is easy to diffuse in the body and be degraded by enzymes in the body tissue, the retention time is short, and it cannot achieve long-term beauty effects
The patent with the application number 200810009193.1 discloses a mixed gel and its preparation method. The preparation process is cumbersome and the retention time in the body is short, so it cannot achieve long-term beauty effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A gel comprising the following components in parts by weight: 20 parts of polycaprolactone, 25 parts of hyaluronic acid, 20 parts of polyethylene glycol, 5 parts of carboxymethyl cellulose, 3 parts of saffron extract, arbutin 5 parts, lidocaine 3 parts.

[0023] The preparation method of the gel described in this embodiment is:

[0024] (1) After dissolving hyaluronic acid in water, add 1,4-butanediol glycidyl ether as a crosslinking agent, and wait for it to swell to form hyaluronic acid hydrogel. The amount of water is 10% of the weight of hyaluronic acid. times, the amount of cross-linking agent is 0.05 times the weight of hyaluronic acid;

[0025] (2) Polycaprolactone, polyethylene glycol, carboxymethylcellulose, saffron extract, arbutin, lidocaine are mixed according to the proportion and dissolved in the hyaluronic acid hydrogel prepared in step (1) , a gel was obtained.

Embodiment 2

[0027] A gel comprising the following components in parts by weight: 3 parts of polycaprolactone, 35 parts of hyaluronic acid, 2 parts of polyethylene glycol, 1 part of carboxymethyl cellulose, 1 part of saffron extract, arbutin 1 part, 1 part of lidocaine.

[0028] The preparation method of the gel described in this example is the same as in Example 1.

Embodiment 3

[0030] A gel comprising the following components in parts by weight: 30 parts of polycaprolactone, 4 parts of hyaluronic acid, 25 parts of polyethylene glycol, 10 parts of carboxymethyl cellulose, 5 parts of saffron extract, arbutin 10 parts, 5 parts of lidocaine.

[0031] The preparation method of the gel described in this example is the same as in Example 1.

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PUM

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Abstract

The invention relates to gel and a preparation method and application thereof, and belongs to the field of medicines. The gel is prepared from the following components in parts by weight: 3-30 parts of polycaprolactone, 4-35 parts of hyaluronic acid and 2-25 parts of polyethylene glycol. According to the gel and the preparation method and the application thereof, the polycaprolactone, the hyaluronic acid and the polyethylene glycol with specific proportions are adopted, the stability is high, the gel does not cause irritation to skin, local retention time is long, the plasticity is good, and awrinkle removing effect is obvious.

Description

technical field [0001] The invention relates to a gel and its preparation method and application, belonging to the field of medicine. Background technique [0002] In recent years, medical aesthetics has developed rapidly. Compared with animal-derived materials, artificial chemically synthesized polymer materials have reduced the risk of infection and are safe to use, making their use gradually larger. In order to meet the needs of the medical aesthetics industry at this stage In order to meet the needs of development, there is an urgent need to invent a product that has a good shape and effect in the short term, and can persist or stimulate subcutaneous collagen hyperplasia in the medium and long term. The most important thing is that it can be completely degraded by the human body and has no toxic side effects. [0003] The patent with application number 200810009190.8 discloses a suspension of hyaluronic acid or its salt containing macromolecular hydrogel and its preparat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/20A61L27/26A61L27/36A61L27/52A61L27/54A61K8/04A61K8/60A61K8/66A61K8/67A61K8/73A61K8/86A61K8/9728A61K8/9789A61Q19/08
CPCA61K8/042A61K8/602A61K8/66A61K8/676A61K8/678A61K8/735A61K8/86A61L27/18A61L27/20A61L27/26A61L27/36A61L27/52A61L27/54A61Q19/08A61K8/9728A61K8/9789C08L5/08C08L67/04C08L71/02
Inventor 陈炯锋
Owner 广州远想生物科技股份有限公司
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