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Vaginal care antibacterial gel as well as preparation method and application thereof

A gel and vaginal technology, applied in the field of medicine, can solve the problems of difficult to form gel products, affect the bacteriostatic effect, insoluble in water, etc., and achieve the effects of inhibiting itching, non-toxic and side effects, and improving vaginal dryness

Inactive Publication Date: 2019-02-12
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, ylang-ylang essential oil, geranium essential oil, and propolis are difficult to dissolve in water, and it is difficult to form a stable gel product by simply mixing with water and carbomer according to this patented formula
Moreover, these ingredients in the prepared gel product are also difficult to diffuse in the water phase, which affects the exertion of its antibacterial effect.

Method used

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  • Vaginal care antibacterial gel as well as preparation method and application thereof
  • Vaginal care antibacterial gel as well as preparation method and application thereof
  • Vaginal care antibacterial gel as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Embodiment 1: the preparation of vagina care gel of the present invention

[0048] I, preparation solution phase A

[0049] 0.5 parts by weight of chitosan, 1.0 parts by weight of hydroxyethyl cellulose, 1.5 parts by weight of xanthan gum, 75 parts by weight of water and 8.0 parts by weight of glycerin were heated and stirred at a temperature of 70°C to mix and dissolve to obtain a solution phase A;

[0050] II. Preparation of Solution Phase B

[0051] Take 100 grams of propolis raw material, add 500 milliliters of 65% ethanol, stir and extract for 48 hours, remove ethanol by rotary evaporation, and obtain propolis fluid extract extract.

[0052]Heat and stir 5.0 parts by weight of propolis extract, 1.0 parts by weight of Fructus Cnidii extract, 3.0 parts by weight of Kochia chinensis extract, 3.0 parts by weight of aloe extract, and 2.0 parts by weight of Sophora flavescens extract with 10.0 parts of propylene glycol at a temperature of 50 ° C Make it mix and dissolv...

Embodiment 2

[0072] Embodiment 2: the preparation of vagina care gel of the present invention

[0073] I, preparation solution phase A

[0074] 1.0 parts by weight of chitosan, 0.8 parts by weight of hydroxyethyl cellulose, 2.0 parts by weight of xanthan gum, 65 parts by weight of water and 12.0 parts by weight of glycerin were heated and stirred at a temperature of 75°C to mix and dissolve to obtain a solution phase A;

[0075] II. Preparation of Solution Phase B

[0076] Take 100 grams of propolis raw material, add 500 ml of 60% ethanol, stir and extract for 48 hours, remove the ethanol by rotary evaporation, and obtain propolis liquid extract.

[0077] 10.0 parts by weight of propolis extract, 0.5 parts by weight of Fructus Cnidii extract, 2.0 parts by weight of Kochia chinensis extract, 1.5 parts by weight of aloe extract, 3.0 parts by weight of Sophora flavescens extract and 12.0 parts of propylene glycol were heated and stirred at a temperature of 55°C Make it mix and dissolve to o...

Embodiment 3

[0097] Embodiment 3: the preparation of vagina care gel of the present invention

[0098] I, preparation solution phase A

[0099] 2.0 parts by weight of chitosan, 0.08 parts by weight of hydroxyethyl cellulose, 0.1 part by weight of xanthan gum, 80 parts by weight of water and 5.0 parts by weight of glycerin were heated and stirred at a temperature of 65°C to mix and dissolve, and a solution phase A was obtained;

[0100] II. Preparation of Solution Phase B

[0101] Take 100 grams of propolis raw material, add 500 milliliters of 70% ethanol, stir and extract for 48 hours, remove ethanol by rotary evaporation, and obtain propolis fluid extract extract.

[0102] 8.0 parts by weight of propolis extract, 3.0 parts by weight of Fructus Cnidii extract, 5.0 parts by weight of Kochia chinensis extract, 1.0 parts by weight of aloe extract, 2.5 parts by weight of Sophora flavescens extract and 6.0 parts of propylene glycol were heated and stirred at a temperature of 55°C Make it mix ...

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Abstract

The invention provides vaginal care antibacterial gel, which is prepared from propolis, fructus cnidii, fructus kochiae, aloe, radix sophorae flavescentis, glycerine, chitosan, hydroxyethyl cellulose,xanthan gum, propanediol and water. The vaginal care antibacterial gel provided by the invention can be used for preparing vaginal care medicine. The antibacterial gel of the invention can be used for effectively and deeply relieving vaginal dryness, and can effectively inhibit pruritus and prevent various kinds of vagina inflammation and the like; raw materials used are food grade raw materials;no harm is caused on the human body skin; no pollution is caused to the environment; no stimulation exists; no chemical antibacterial agents exists; no toxic or side effect exists; safety and reliability are realized; drug resistance cannot be generated, so that the safety and the reliability are realized.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a vaginal nursing antibacterial gel and a preparation method and application thereof. Background technique [0002] Vaginitis is a common disease in gynecology, mainly divided into bacterial vaginosis, fungal vaginitis, non-specific vaginitis and trichomonal vaginitis. The main clinical manifestations are increased vaginal discharge, peculiar smell, and genital itching, etc., and may also be accompanied by symptoms such as dyspareunia, genital burning pain, urgency, frequent urination, and painful urination. disease. [0003] The unique flavonoids and terpenes in propolis can inhibit and kill a variety of bacteria, fungi, viruses and parasites. Studies have shown that propolis has a certain effect on vaginal inflammation such as Trichomonas vaginalis, Staphylococcus aureus, Escherichia coli, and Candida albicans. [0004] Chitosan and its derivatives have good antibacterial act...

Claims

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Application Information

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IPC IPC(8): A61K36/886A61K36/896A61K9/06A61K47/36A61K47/38A61P15/02A61P31/04A61K31/722A61K35/644A61K36/185A61K36/234A61K36/489
CPCA61K9/0034A61K9/06A61K31/722A61K35/644A61K36/185A61K36/234A61K36/489A61K36/886A61K36/896A61K47/36A61K47/38A61P15/02A61P31/04A61K2300/00
Inventor 张翠平
Owner ZHEJIANG UNIV
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