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Yixinshu tablet and preparation method

A technology of Yixinshu tablets and Yixinshu is applied in the field of Chinese patent medicine tablets and their preparation, which can solve the problems of many fine powders, splintered fragments, poor stability, etc., and achieve the finished product with neat particles, uniform particle size and less material loss. Effect

Inactive Publication Date: 2019-02-01
GUIZHOU XINBANG PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The Chinese patent application with the publication number 103784726A discloses a preparation method of Yixinshu Tablets. During the operation of the method, the greater the concentration of ethanol, the lower the viscosity after wetting, resulting in a wide range of wet particle size distribution and not Uniform, fine powder, resulting in flower flakes, lobes and other phenomena during tablet compression, the prepared Yixinshu tablet disintegrates for a long time, and after a period of storage, disintegration time limit, poor stability, and unqualified microorganisms will appear. Phenomenon

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Prescription: 1500g ginseng, 1500g Ophiopogon japonicus, 950g schisandra, 1500g astragalus, 2400g salvia, 950g Chuanxiong, 1500g hawthorn

[0023] Preparation method: (1) For the above seven flavors, take 1500g ginseng and grind it into fine powder for later use. 950g schisandra chinensis and 2400g salvia miltiorrhiza were extracted twice with 85% ethanol under reflux, firstly add 6 times of 85% ethanol, reflux for 3 hours, add 95% ethanol for 5 times for the second time, reflux for 1.5 hours, filter, The combined filtrates were concentrated under reduced pressure to a relative density of 1.15 to 1.12 (20°C) to obtain an alcoholic extract. Add 1500g Ophiopogon japonicus, 1500g Astragalus membranaceus, 950g Chuanxiong and 1500g hawthorn with water and decoct twice, add 10 times the amount (weight) of water for the first time, decoct for 2.5 hours, add 8 times the amount of water for the second time, decoct for 1.5 hours, combine Decoction, filter, concentrate the filtra...

Embodiment 2

[0028] Prescription: 1200g ginseng, 1500g Ophiopogon japonicus, 1000g schisandra, 1200g astragalus, 2000g salvia, 1000g Chuanxiong, 1200g hawthorn

[0029] Preparation method: (1) For the above seven flavors, take 1200g ginseng and grind it into fine powder for later use. 1000g schisandra chinensis and 2000g salvia miltiorrhiza were extracted twice with 85% ethanol under reflux, firstly add 6 times of 85% ethanol, reflux for 3 hours, add 95% ethanol for 5 times for the second time, reflux for 1.5 hours, filter, The combined filtrates were concentrated under reduced pressure to a relative density of 1.15 to 1.12 (20°C) to obtain an alcoholic extract. Add 1500g Ophiopogon japonicus, 1200g Astragalus membranaceus, 1000g Chuanxiong and 1200g hawthorn with water and decoct twice, add 10 times the amount (weight) of water for the first time, decoct for 2.5 hours, add 8 times the amount of water for the second time, decoct for 1.5 hours, combine Decoction, filter, concentrate the fi...

Embodiment 3

[0034] Prescription: 1800g ginseng, 1600g Ophiopogon japonicus, 1100g schisandra, 1400g astragalus, 2200g salvia, 1100g Chuanxiong, 1300g hawthorn

[0035] Preparation method: (1) For the above seven flavors, take 1800g ginseng and grind it into fine powder for later use. 1100g schisandra chinensis and 2200g salvia miltiorrhiza were extracted twice with 85% ethanol under reflux, firstly add 6 times of 85% ethanol, reflux for 3 hours, add 85% ethanol for 5 times for the second time, reflux for 1.5 hours, filter, The combined filtrates were concentrated under reduced pressure to a relative density of 1.15 to 1.12 (20°C) to obtain an alcoholic extract. Add water to decoct 1600g Ophiopogon japonicus, 1400g Astragalus membranaceus, 1100g Chuanxiong and 1300g hawthorn twice, add 10 times the amount (weight) of water for the first time, decoct for 2.5 hours, add 8 times the amount of water for the second time, decoct for 1.5 hours, combine Decoction, filter, concentrate the filtrate...

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Abstract

The invention relates to a Yixinshu tablet and a preparation method. Specifically, the Yixinshu tablet is prepared by extraction of ginseng, radix ophiopogonis, Schisandra chinensis, radix astragali,Salvia miltiorrhiza, Ligusticum wallichii and hawthorn as the raw materials. During preparation of the tablet, 75% ethanol is employed for granulation, has strong viscosity, and is suitable for botanical drugs with loose texture and strong elasticity, and the obtained particles are subjected to size stabilization, the hardness and taste are good, and after tabletting, the obtained tablet has smooth and flat surface, and has good application value.

Description

technical field [0001] The invention relates to the field of Chinese patent medicine tablet and its preparation, in particular to Yixinshu tablet and its preparation method. Background technique [0002] Cardiovascular and cerebrovascular diseases are currently one of the most important factors affecting human health and causing death. According to literature reports, more than 20 million people die of cardiovascular and cerebrovascular diseases in the world every year, and nearly 400,000 in my country. Traditional Chinese medicine has accumulated rich clinical experience in the diagnosis and treatment of this disease, and traditional Chinese medicine prescriptions have unique advantages in the treatment of cardiovascular and cerebrovascular diseases. Chest pain and angina pectoris of coronary heart disease belong to the category of "chest pain" in traditional Chinese medicine. The etiology of thoracic obstruction is related to the internal invasion of cold evil, improper d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61K9/20A61K47/36A61P9/10
CPCA61K36/258A61K9/2059A61K36/236A61K36/481A61K36/537A61K36/57A61K36/734A61K36/79A61K36/8968A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61P9/10A61K2300/00
Inventor 安怀略
Owner GUIZHOU XINBANG PHARMACEUTICAL CO LTD
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