Nitride oxide nanocomposite hydrogel and preparation method and application thereof

Abstract

The invention relates to the technical field of biomedical materials, and provides a nitride oxide nanocomposite hydrogel. The nitride oxide nanocomposite hydrogel is constituted by S-nitrosoglutathione (GSNO) loaded Eudragit RS PO nano suspension and a gel matrix in a mixed mode, the gel matrix is prepared from sodium alginate, a calcium chloride solution and glycerin, and mixed gel contains nanoparticles with Eudragit RS PO loaded with GSNO. The invention further provides a preparation method of the nitride oxide nanocomposite hydrogel and application of the nitride oxide nanocomposite hydrogel in the field of the biomedical materials. According to the nitride oxide nanocomposite hydrogel, aiming at two critical periods of the inflammation period and the proliferation period in skin wound healing, the nitric oxide nanocomposite hydrogel is constructed by taking the sodium alginate as a matrix phase and taking the nanoparticles with the Eudragit RS PO loaded with nitric oxide donor GSNO as a dispersion phase, nitric oxide is released at the wound part, thus generating of angiogenesis and generating of fibroblast in the inflammation period of wound repair are promoted, and generating of collagenous fibers in the proliferation period is promoted, so that the purpose of effectively promoting skin wound healing is achieved.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a nitric oxide nanocomposite hydrogel and its preparation method and application. Background technique [0002] Skin is the largest organ in mammals, including the entire body surface and the part in contact with the external environment. It not only serves as a protective barrier for the body, but also plays a vital role in maintaining the physiological homeostasis of the mammalian body. Skin integrity damage makes individuals prone to physiological imbalances. The body has self-healing ability in a good environment. The wound healing process of the skin is regulated by various biological factors. It is mainly divided into three stages: inflammation and contraction response stage: establishment of immune system in the body Response, dissolution, removal of necrotic tissue and exudate; granulation tissue repair stage: connective tissue cells and vascular endothelial ...

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Problems solved by technology

[0005] It has been mentioned in previous reports that NO can participate in the regulation of wound healing and accelerate skin wound healing through complex and unclear mechanisms. However, NO is a gas molecule, and it is difficult to directly use it for wound healing in clinical practice. Therefore, NO Donors release NO to address this

The inventors of the present invention have found through research that GSNO, as an endogenous NO donor, has good biocompatibility and can effectively promote skin wound healing, but due to the short half-life of GSNO and relatively unstable chemical properties, How to protect it, improve its stability to meet the needs of storage and clinical application, and to prepare a suitable drug delivery system to promote skin wound healing has become an urgent problem to be solved.

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