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A kind of nitrofuran antibiotic sensor and its preparation method

A technology of nitrofuran and antibiotics, which is applied in the direction of instruments, scientific instruments, and electrochemical variables of materials, can solve the problems of reduced sensitivity of electrochemical sensors, restrictions on the application of molecularly imprinted membranes, and reduced stability and reproducibility, and achieves excellent results. Electron transfer capability, reduced detection cost, and convenient operation

Active Publication Date: 2021-01-12
UNIV OF JINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the preparation process of traditional MIP-ECS, there are disadvantages such as difficult elution of template molecules, difficulty in controlling the thickness of imprinted membranes, and poor reproducibility, which limit the application of molecularly imprinted membranes in electrochemical sensors.
These problems, especially the difficult control of the thickness of the molecularly imprinted membrane, which leads to the decrease of the sensitivity of the electrochemical sensor, and the technical difficulties that the molecularly imprinted membrane is easily detached from the electrode surface during the elution process, resulting in a decrease in stability and reproducibility, limit the application of MIP_ECS. It is of great research significance and market value to find new synthesis methods for molecularly imprinted polymers, new methods for modifying molecularly imprinted membrane electrodes, and methods for combining molecularly imprinted membranes with substrate materials to solve the problems of preparation and application of MIP-ECS.

Method used

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  • A kind of nitrofuran antibiotic sensor and its preparation method
  • A kind of nitrofuran antibiotic sensor and its preparation method
  • A kind of nitrofuran antibiotic sensor and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030]Example 1 Preparation of CoNi LDH-nanoarray

[0031](1) Use dilute hydrochloric acid, absolute ethanol and deionized to clean the disposable electrode with ultrasonic cleaning to remove the oxide layer and surface impurities of the disposable electrode;

[0032](2) Weigh 1 mmol Ni(NO3)2And Co(NO3)2And 3 mmol urea CO(NH2)2, Put it in a 50 mL beaker, add 30 mL deionized water and stir until it is clear, then transfer it to a 50 mL PTFE reactor;

[0033](3) Put the disposable disposable electrode processed in step (1) into the solution in the reaction kettle in step (2), and react at 100 ℃ for 12 hours to prepare cobalt-nickel bimetal layered hydrogen Oxide nanosheet array precursor electrode;

[0034](4) Insert the cobalt-nickel bimetal layered hydroxide nanosheet array precursor electrode obtained in step (3) into a phosphate buffer solution PBS containing dopamine, ammonium persulfate and cobalt nitrate, and react at a temperature of 20 ℃ After 4 hours, take it out and immerse it in deion...

Embodiment 2

[0036]Example 2 Preparation of CoNi LDH-nanoarray

[0037](1) Use dilute hydrochloric acid, absolute ethanol and deionized to clean the disposable electrode with ultrasonic cleaning to remove the oxide layer and surface impurities of the disposable electrode;

[0038](2) Weigh 2 mmol Ni(NO3)2And Co(NO3)2And 6 mmol urea CO(NH2)2, Put it in a 50 mL beaker, add 30 mL deionized water and stir until it is clear, then transfer it to a 50 mL PTFE reactor;

[0039](3) Put the disposable disposable electrode processed in step (1) into the solution in the reaction kettle in step (2), and react at 110 ℃ for 11 hours to prepare cobalt-nickel bimetal layered hydrogen Oxide nanosheet array precursor electrode;

[0040](4) Insert the cobalt-nickel bimetallic layered hydroxide nanosheet array precursor electrode obtained in step (3) into a phosphate buffer solution PBS containing dopamine, ammonium persulfate and cobalt nitrate, and react at a temperature of 30 ℃ After 5 hours, take it out and immerse it in de...

Embodiment 3

[0042]Example 3 Preparation of CoNi LDH-nanoarray

[0043](1) Use dilute hydrochloric acid, absolute ethanol and deionized to clean the disposable electrode with ultrasonic cleaning to remove the oxide layer and surface impurities of the disposable electrode;

[0044](2) Weigh 3 mmol Ni(NO3)2And Co(NO3)2And 9 mmol urea CO(NH2)2, Put it in a 50 mL beaker, add 30 mL deionized water and stir until it is clear, then transfer it to a 50 mL PTFE reactor;

[0045](3) Put the disposable disposable electrode processed in step (1) into the solution in the reaction kettle in step (2), and react at 130 ℃ for 9 hours to prepare cobalt-nickel bimetallic layered hydrogen Oxide nanosheet array precursor electrode;

[0046](4) Insert the cobalt-nickel bimetallic layered hydroxide nanosheet array precursor electrode obtained in step (3) into a phosphate buffer solution PBS containing dopamine, ammonium persulfate and cobalt nitrate, and react at a temperature of 40 ℃ After 6 hours, take it out and immerse it in ...

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Abstract

The invention discloses a preparation method of a nitrofuran antibiotic sensor, and belongs to the technical field of new nano functional materials and biosensing analysis technology. The method comprises the following steps: firstly preparing an array of cobalt-nickel bimetal layered hydroxide nanosheets on a disposable electrode, directly preparing a polydopamine film containing an electron mediator and a molecularly imprinted polymer using the nitrofuran antibiotic as a template molecule successively on the array of cobalt-nickel bimetal layered hydroxide nanosheets one after another by adopting an in-situ growth method and utilizing a large specific surface area and high active hydroxyl functional groups, and eluting the molecularly imprinted polymer of the template molecule after thetemplate molecule is eluted and the original position of the template molecule became a hole, thereby preparing a nitrofuran antibiotic sensor.

Description

Technical field[0001]The invention relates to a preparation method and application of an electrochemical analysis sensor. It belongs to the field of new nano-functional materials and biosensing analysis technology.Background technique[0002]Nitrofuran antibiotics are a class of 5-nitro-2 substituted furan derivatives, which were once an important class of anti-infective drugs. Such drugs mainly include furazolidone, nitrofurantoin, nitrofurazone, etc., which are mainly used to treat urinary tract infections, intestinal bacterial infections, skin wound infections and as food additives to prevent poultry intestinal infectious diseases. However, due to the genetic toxicity and carcinogenic effects of furazolidone, the US Food and Drug Administration (FDA) and European Medicines Agency (EMA) have banned its use in humans and animals in 2005. In addition, nitroheterocyclic compounds have cell mutagenicity and animal carcinogenic toxicity, which has attracted clinical attention. Therefore,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/26G01N27/30G01N27/327
CPCG01N27/26G01N27/30G01N27/3278
Inventor 张勇刘召壹魏琴
Owner UNIV OF JINAN
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