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Filtering method adopted in preparing process of arenobufagin injection

A technology for the preparation and filtration of injection liquid, applied in the field of preparation of toad venom, can solve the problems of insufficient grinding and waste of toad venom, and achieve the effects of avoiding insufficient grinding, avoiding waste, and improving yield and purity.

Inactive Publication Date: 2019-01-22
江苏浦金药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to solve the deficiencies of the prior art, the purpose of the present invention is to provide a filtration method in the preparation process of toad venom injection, which can grind toad venom sufficiently and finer, avoid the problem of insufficient grinding of toad venom, and can fully filter out impurities , and can avoid the waste of the filtrate entrained in the filter residue, and further improve the yield and purity of the product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A filtration method in the preparation process of Chansu injection, comprising the following specific steps:

[0023] S1. Take 10g of toad venom, soak it in propylene glycol for 15 minutes, take it out and put it in a heating room for drying. The temperature of the heating room is 80°C, the heating rate is 8°C / min, and the drying time is 0.5h. Take it out, and when the temperature drops to 30°C, grind toad venom for the first time. After grinding for 0.4 hours, the fine powder of toad venom will be 150 mesh, and then perform the second grinding treatment. After 0.6 hour of grinding, the fine powder of toad venom will be 230 mesh. Grinding powder of toad cake, set aside;

[0024] S2. The ingredients are prepared according to the following parts by weight: 22 parts of Chansu fine powder, 21 parts of ethanol, 13 parts of Astragalus membranaceus, 15 parts of Adenophora japonicus, 11 parts of glycerin, 18 parts of disodium edetate, sodium chloride 14 parts, 6 parts of anhyd...

Embodiment 2

[0031] A filtration method in the preparation process of Chansu injection, comprising the following specific steps:

[0032] S1. Take 15g of toad venom, soak it in propylene glycol for 25 minutes, take it out and put it in a heating room for drying. The temperature of the heating room is 95°C, the heating rate is 13°C / min, and the drying time is 1.3h. Take it out, and when the temperature drops to 35°C, grind toad venom for the first time. After grinding for 0.8 hours, the fine powder of toad venom is 180 mesh, and then perform the second grinding treatment. After 0.9 hour of grinding, the fine powder of toad venom is 260 mesh. Grinding powder of toad cake, set aside;

[0033] S2. The ingredients are prepared according to the following parts by weight: 27 parts of Chansu fine powder, 29 parts of ethanol, 22 parts of Astragalus membranaceus, 20 parts of Radix Adenophora, 17 parts of glycerin, 25 parts of disodium edetate, sodium chloride 19 parts, 13 parts of anhydrous sodium ...

Embodiment 3

[0040] A filtration method in the preparation process of Chansu injection, comprising the following specific steps:

[0041] S1. Take 12g of toad venom, soak it in propylene glycol for 20 minutes, take it out and put it in a heating room for drying. The temperature of the heating room is 85°C, the heating rate is 11°C / min, and the drying time is 1h. After drying, take it out , when the temperature drops to 32°C, the toad venom powder is ground for the first time, and the fine powder of toad venom is 170 mesh after grinding for 0.6 hours, and then the second grinding treatment is carried out, and the fine powder of toad venom is 250 mesh after grinding for 0.8 hours, and the toad venom powder is obtained Grinding powder, spare;

[0042] S2. The ingredients are prepared according to the following parts by weight: 25 parts of Chansu fine powder, 25 parts of ethanol, 17 parts of Astragalus membranaceus, 18 parts of Radix Ginseng, 14 parts of glycerin, 21 parts of disodium edetate,...

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Abstract

The invention discloses a filtering method adopted in a preparing process of an arenobufagin injection. The filtering method comprises the following specific steps: 10-15 g of arenobufagin is taken and soaked in propylene glycol, the arenobufagin is taken out and then placed into a heating room to be dried, and the arenobufagin is ground after being dried; a mixed solution is placed into a refrigerating chamber to be refrigerated, the mixed solution is taken out and then subjected to first-time filtering and second-time filtering, first-time filter residues and second-time filter residues aremixed together, carbon tetrachloride is added, after stirring and dissolving, filtering is carried out, the carbon tetrachloride is heated and recovered, and a third-time clear solution and third-timefilter residues are obtained; and a first-time clear solution, a second-time clear solution and the third-time clear solution are combined, and an arenobufagin extractive is obtained.

Description

technical field [0001] The invention belongs to the technical field of toad venom preparation, and in particular relates to a filtration method in the preparation process of toad venom injection. Background technique [0002] Toad venom is processed from the secretions of the auricular glands and skin glands of amphibians and reptiles of the Bufo family. It is a traditional Chinese medicinal material. Steroids, alkaloids and other biologically active substances contained in toad venom have multiple functions such as detoxification, analgesia, resuscitation, and antitumor, and are widely used. The way to get the crisp is to put the toad in a basket, shake it gently in the water, wash off the sediment on the body surface, drain the water and then scrape the pulp. Chansu Injection has the effect of clearing heat and detoxifying, and can be widely used in the treatment of various acute and chronic suppurative infections such as carbuncles, sores and sores with flaming heat and ...

Claims

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Application Information

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IPC IPC(8): A61K35/65A61K9/08A61J3/00A61K36/481A61K36/23
CPCA61J3/00A61K9/0019A61K9/08A61K35/65A61K36/23A61K36/481
Inventor 李华
Owner 江苏浦金药业有限公司
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