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Preparation method of glycine

A technology for glycine and preparation steps, applied in the field of compound preparation, can solve the problems of large centrifugal separation processing capacity, difficult methanol mother liquor treatment, and high production cost, achieve low production cost, overcome organic solvent and energy consumption, and reduce recovery costs. Effect

Inactive Publication Date: 2019-01-15
刘笃琏
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the purification method of this production process still adopts the method of directly adding methanol to extract the reaction solution, which fails to solve the problem of large centrifugation processing capacity caused by the use of a large amount of methanol, difficulty in post-processing of methanol mother liquor recovery, high production cost, and Environmental pollution and other issues

Method used

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  • Preparation method of glycine
  • Preparation method of glycine

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preparation example Construction

[0030] A kind of preparation method of glycine, the steps of the first round of preparation are as follows:

[0031] A. Replacement reaction: Add chloroacetic acid into the reaction vessel, then add the alcohol solution of iodide, and stir evenly. The iodide is any one or more of ammonium iodide, sodium iodide, and potassium iodide. It is any one or a mixture of methanol, ethanol or propanol, the mass ratio of chloroacetic acid and iodide reaction is 1:0.5~5, and the mass ratio of iodide in the iodide alcohol solution is 10~50 %. Heat the reaction solution to a temperature of 30-65°C to carry out the displacement reaction, and keep stirring. The preferred temperature range is 55-65°C, and the reaction time is 30-180 minutes, preferably 90-150 minutes. After the reaction, stop heating and cool After reaching 20-35°C, solid-liquid separation is carried out by centrifugation or filtration. The obtained solid is chloride, which can be sold outside after drying. The liquid is an a...

Embodiment 1～4

[0038] Examples 1-4 have the same production process steps as the above-mentioned specific examples, and the different process parameters or selected different types of compounds are shown in Table 1 below. Among them, "iodide" is the type of iodide, the ratio value in the table is the mass ratio when several iodides are mixed, "alcohol" is the type of alcohol, and the ratio value in the table is the mass ratio when several alcohols are mixed .

[0039] Table 1

[0040]

[0041]

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Abstract

The invention discloses a preparation method of glycine, and belongs to a preparation method of amino acid. The preparation method comprises two-step reactions of replacement and ammoniation. The preparation method comprises the following specific steps: firstly performing a replacement desalting reaction between chloroacetic acid and an alcoholic solution of iodide under the heating condition, and then centrifuging or filtering after the reaction to respectively obtain chloride and an alcoholic solution of iodoacetic acid; and adding a catalyst into the alcoholic solution of iodoacetic acid,heating and introducing ammonia gas for ammoniation, and centrifuging or filtering after the reaction to respectively obtain glycine and a catalyst-containing alcoholic solution of iodide. The reaction liquid can be recycled, cumbersome energy-consuming links such as organic solvent extraction, rectification, evaporation, etc. can be saved; waste liquids that need environmental protection treatment are not generated; and yield and purity of the product can be improved. The preparation method has the following advantages: production cost is low; operation is simple; raw materials are easily available; and the preparation method meets the clean and environmental protection requirements and is suitable for industrial large-scale production.

Description

technical field [0001] The invention relates to a method for preparing a compound, in particular to a method for preparing an amino acid, and belongs to the technical field of preparing glycine by ammoniating chloroacetic acid. Background technique [0002] Glycine is also known as glycine, and its molecular formula is NH 2 CH 2 COOH is an important basic organic raw material and fine chemical product, widely used in organic chemical industry, medicine, food, pesticide, feed and other industries. For example, glycine can be used in the pharmaceutical industry as an amino acid preparation, as a buffer for aureomycin, and as a raw material for the synthesis of other amino acids, such as phenylalanine, threonine, and serine. In terms of food, glycine is often added to various foods as a food additive for seasoning, sterilization, antisepsis, anti-oxidation, nutritional enhancement, etc. After eating, it is convenient for the body to absorb and synthesize other essential and n...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C227/08C07C229/08
CPCC07C227/08C07C51/363C07C229/08C07C53/16
Inventor 刘笃琏王立辉
Owner 刘笃琏
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