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Supermolecular sensor based on host-guest self-assembly and preparation and application thereof

A technology of host-guest self-assembly and guest molecules, applied in the field of ion detection, can solve the problems of few reports

Inactive Publication Date: 2019-01-11
NORTHWEST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the weak basicity and spherical structure of I, it is difficult for general anion receptors to bind to I to selectively detect I, so there are few reports on I receptors.

Method used

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  • Supermolecular sensor based on host-guest self-assembly and preparation and application thereof
  • Supermolecular sensor based on host-guest self-assembly and preparation and application thereof
  • Supermolecular sensor based on host-guest self-assembly and preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1. Synthesis of supramolecular sensor PQDP-Ag

[0050] 1. Synthesis of main molecule PQ

[0051] (1) Synthesis of two-sided four-carbon pillar [5] arene P5C4: by literature method: T. B. Wei, J. F. Chen, X.B. Cheng, H. Li, B. B. Han, Y. M. Zhang, H. Yao and Q. Lin. Org. Chem. Front., 2017, 4, 210.

[0052] (2) Synthesis of 8-hydroxyquinoline functionalized column[5]arene PQ: add 1mmol (0.9923g) of two-sided carbon column[5]arene P5C4 and 0.5mmol (0.0829g) of potassium iodide to a 100mL round bottom flask and 60mL of acetonitrile, stirred at room temperature for 30 minutes, added anhydrous potassium carbonate 10mmol (1.3791g) and 8-hydroxyquinoline 2.5mmol (0.3626g), immediately with N 2 protection, the mixture was heated to reflux at 90°C for 72 hours, mixed with silica gel, spin-dried, and purified by column chromatography (petroleum ether:ethyl acetate=5:1v / v), and the obtained pale yellow product was PQ. Yield: 50.8%, melting point: 97~103°C.

[0053] 2. ...

Embodiment 2

[0057] Example 2: Supramolecular Sensor PQDP Fluorescence Recognition of Ag +

[0058] Take 13 10mL colorimetric tubes, respectively pipette 0.5mL DMSO solution with the above PQDP into the 13 colorimetric tubes, 1.0 mLH 2 O, and then add 13 kinds of common cationic Ag respectively + , Zn 2+ , Fe 3+ , Hg 2+ , Ni 2+ , Ca 2+ , Cu 2+ ,Co 2+ , Cd 2+ , Pb 2+ , Cr 3+ , Mg 2+ and Al 3+ DMSO solution (0.02mol L -1 ) 0.5mL, and finally dilute to 5.0mL with DMSO, shake to mix evenly, and detect the fluorescence response of PQDP to cations with a fluorescence spectrophotometer. If the fluorescence of the sensor PQDP is significantly enhanced, it means that the addition of Ag +. If the fluorescence of the sensor PQDP does not change significantly, it means that other ions are added.

Embodiment 3

[0059] Embodiment three, supramolecular sensor complex PQDP-Ag fluorescence recognition I -

[0060] Take 13 10mL colorimetric tubes, and pipette 0.5mL of the DMSO solution of PQDP into the 13 colorimetric tubes respectively. 2 O 1.mL, Ag + DMSO solution (0.02mol L -1 ) 0.5mL; then add F - , Cl - , Br - , I - , AcO - , H 2 PO 4 - , HSO 4 - , ClO 4 - , SCN - and CN - solution (0.1mol L -1 ) 0.5mL, and finally dilute to 5.0mL with DMSO, shake to mix evenly, and detect the fluorescence response of PQDP-Ag to anions with a fluorescence spectrophotometer. If the fluorescence of the sensor complex PQDP-Ag is red-shifted and enhanced, it means that the addition of I - .

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Abstract

The invention discloses a supermolecular sensor based on host-guest self-assembly, which is formed from a complexing of functional pillar [5] arenes as host, and 2-pyridine derivative DP as object inan H2O-MSO system. The supermolecular sensor can coordinate with Ag+ to form a supermolecular sensor complex PQDP-Ag, accompanied by fluorescence enhancement, so the supermolecular sensor can be usedfor single selective fluorescence recognition of Ag+, with a lowest limit of detection of 6.04x10-9 M. If added I-, fluorescence of the sensor complex PQDP-Ag is redshifted and enhanced. As a result,PQDP-Ag can identify I- efficiently, continuously and selectively, with a lowest limit of detection of 4.40x10-9 M. The invention also prepares a test paper carrying the supermolecular sensor, which can detect Ag+ ions in solution well, and has the advantages of portability, obvious phenomenon and rapid detection.

Description

technical field [0001] The present invention relates to a supramolecular sensor based on host-guest self-assembly, in particular to a supramolecular sensor with 8-hydroxyquinoline functionalized pillar[5]arene as the main body and bis-pyridine derivatives as the guest, which is complexed by self-assembly The supramolecular sensor that becomes; The present invention also relates to this supramolecular sensor in supersensitive detection Ag + and Continuity Identification I - The application belongs to the field of ion detection. Background technique [0002] Silver Ag is one of the most abundant transition metals in mammals and industry, the silver ion Ag + Plays an important role in various biological processes, such as the interaction with DNA; Ag + It affects a variety of physiological activities in living systems, such as combining with enzymes, destroying bacteria and preventing electron transport. All these indicate that silver ions play an important role in the bios...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/64
CPCG01N21/643
Inventor 张有明何俊霞林奇朱伟李永福房虎姚虹魏太保
Owner NORTHWEST NORMAL UNIVERSITY
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