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Method for refining carnosic acid through molecule distillation

A carnosic acid and molecular distillation technology, applied in molecular distillation, separation/purification of carboxylic acid compounds, organic chemistry, etc., can solve the problems of low product extraction rate, high production cost, easy oxidation, etc., and achieve production intensity The effect of low, low production cost and short operating time

Inactive Publication Date: 2019-01-08
HUNAN NUOZ BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, industrial production mainly uses organic reagents for extraction and separation. However, due to the long heating time of this method, oxidation and polymerization reactions are prone to occur, so the extraction rate of the product is not high and the production cost is high.

Method used

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  • Method for refining carnosic acid through molecule distillation
  • Method for refining carnosic acid through molecule distillation
  • Method for refining carnosic acid through molecule distillation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A method for purifying carnosic acid by molecular distillation, comprising the following steps

[0029] (1) Carnosic acid solubilization: Take 1 kg of carnosic acid product with a content of 15% initially extracted by conventional methods, add 2 kg of polyethylene glycol 400, stir and dissolve at 65±2°C;

[0030] (2) Dehydration and degassing by one-stage thin film distillation: the carnosic acid added with co-solvent was pumped steadily into the first-stage thin-film distillation column at a flow rate of 40ml / min for dehydration and degassing by one-stage thin-film distillation. The heating temperature is 90°C, the vacuum degree is 100-200Pa, the rotating speed of the scraping film is 100rpm, and the discharge condensation temperature is 65°C;

[0031] (3) Secondary molecular distillation separation: pump the dehydrated and degassed liquid into the secondary molecular distillation at a flow rate of 40ml / min for secondary molecular distillation separation to obtain 0.05...

Embodiment 2

[0034] A method for purifying carnosic acid by molecular distillation, comprising the following steps:

[0035] (1) Carnosic acid solubilization: Take 1.2kg of carnosic acid product with a content of 23% initially extracted by conventional methods, add 2kg of propylene glycol and stir to dissolve at 65±2°C;

[0036] (2) Dehydration and degassing by one-stage thin film distillation: the carnosic acid added with co-solvent was pumped steadily into the first-stage thin-film distillation column at a flow rate of 40ml / min for dehydration and degassing by one-stage thin-film distillation. The heating temperature is 90°C, the vacuum degree is 100-200Pa, the speed of the scraping film is 100rpm, and the discharge condensation temperature is 60°C;

[0037] (3) Secondary molecular distillation separation: pump the dehydrated and degassed liquid into the secondary molecular distillation at a flow rate of 40ml / min for secondary molecular distillation separation to obtain 0.18kg of light c...

Embodiment 3

[0040] A method for purifying carnosic acid by molecular distillation, comprising the following steps:

[0041] (1) Carnosic acid solubilization: Take 1 kg of carnosic acid product with a content of 28% initially extracted by conventional methods, add 2 kg of glycerol and stir to dissolve at 65±2°C;

[0042] (2) Dehydration and degassing by one-stage thin film distillation: the carnosic acid added with co-solvent was pumped steadily into the first-stage thin-film distillation column at a flow rate of 40ml / min for dehydration and degassing by one-stage thin-film distillation. The heating temperature is 90°C, the vacuum degree is 100-200Pa, the speed of the scraping film is 100rpm, and the discharge condensation temperature is 60°C;

[0043] (3) Secondary molecular distillation separation: pump the dehydrated and degassed liquid into the secondary molecular distillation at a flow rate of 40ml / min for secondary molecular distillation separation to obtain 0.11kg of light component...

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Abstract

The invention discloses a method for refining carnosic acid through molecule distillation. The method comprises the following steps: (1) carrying out carnosic acid dissolution promotion, namely dissolving a carnosic acid product of a low content with a cosolvent; (2) carrying out primary film distillation dehydration and degassing, namely putting the carnosic acid with the cosolvent into a primaryfilm distillation column to carry out primary film distillation dehydration and degassing; (3) carrying out secondary molecule distillation separation, namely pumping a dehydration degassing liquid into a secondary molecule distillation to carry out secondary molecule distillation separation so as to obtain light and weight components, wherein the light component is a part with a part of the carnosic acid; (4) carrying out third molecule distillation separation, namely pumping the heavy component of secondary molecule distillation into a third molecule distiller to carry out third molecule distillation separation so as to obtain light and heavy components, wherein the light component is the carnosic acid. The method has the characteristics of being short in operation time, low in production intensity, low in energy consumption, low in production cost, and the like, and meanwhile is high in product purity and easy in continuous industrial production.

Description

technical field [0001] The invention relates to a method for purifying carnosic acid by molecular distillation. Background technique [0002] Rosemary (Latin scientific name: Rosmarinus officinalis), a shrub of the Lamiaceae. It likes a warm climate and is native to Europe and the Mediterranean coast in northern Africa. It was introduced to China as far back as the Cao Wei period. Antioxidants (carnosic acid and rosmarinic acid) with excellent antioxidant properties and rosemary essential oil can be extracted from the leaves of rosemary. Rosemary antioxidants are widely used in medicine, fried food, oil-rich food and various oils and fats; while rosemary essence is used in spices, air fresheners, termite repellents, and daily products such as sterilization and insecticide. chemical industry. Among them, the carnosic acid, an antioxidant, has a carboxyl hydroxyl group, which is easily oxidized when it encounters light and alkali conditions, and is prone to decomposition o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C51/42C07C51/44C07C62/32B01D3/12
CPCB01D3/12C07C51/42C07C51/44C07C62/32
Inventor 刘智谋
Owner HUNAN NUOZ BIOLOGICAL TECH CO LTD
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