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Biomarker for detecting high altitude hypoxia and application thereof

A biomarker and detection marker technology, applied in measurement devices, instruments, scientific instruments, etc., can solve the problem of lack of quantifiable objective and sensitive clinical diagnostic indicators, and achieve the goal of facilitating the progress of hypoxic injury, easy acceptance, and detection methods. Convenient and fast effect

Inactive Publication Date: 2019-01-04
ACADEMY OF MILITARY MEDICAL SCI
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Problems solved by technology

At present, there is still a lack of quantifiable objective and sensitive clinical diagnostic indicators, and there are no reports on the use of biomarkers to diagnose acute mountain sickness. Will improve the status of diagnosis of altitude sickness

Method used

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  • Biomarker for detecting high altitude hypoxia and application thereof

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Embodiment Construction

[0019] The specific embodiments of the present invention will be described in detail below in conjunction with the accompanying drawings, but it should be understood that the protection scope of the present invention is not limited by the specific embodiments.

[0020] Animals and Simulated High Altitude Hypoxia Exposure

[0021] Rats are SD rats for qualified experimental animals, male, purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. The animals were kept in a constant temperature (23±2°C) and constant humidity animal room, with a 12 / 12h day and night cycle every day, and free access to food and water. The low-pressure hypoxic animal experimental chamber simulating the plateau environment was purchased from Guizhou Fenglei Aviation Ordnance Co., Ltd., model: DYC-DWI. The cabin is connected with two air pumps, which can continuously pump out the gas in the cabin, thereby simulating a low-pressure and low-oxygen environment at a certain altitude; ...

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Abstract

The invention discloses a biomarker for detecting high altitude hypoxia and an application thereof. The biomarker for detecting the high altitude hypoxia is N-acetylneuraminic acid or a specific antibody thereof and used for preparing diagnostic reagent or a kit for detecting the high altitude hypoxia. The method of determining the degree of the high altitude hypoxia by detecting a serum marker helps to detect or assist in detecting hypoxia so as to help to take appropriate treatment measures as soon as possible, and is easy and fast in operation, easy for patients to accept, and convenient for the dynamical monitor of the progress of hypoxic injury in high altitude population.

Description

technical field [0001] The invention belongs to the technical field of detecting plateau hypoxia, and in particular relates to a biomarker for detecting plateau hypoxia and an application thereof. Background technique [0002] People who travel to high altitudes usually face problems such as mental disorders, memory impairment, insomnia, dizziness, nausea, loss of appetite, and motor dysfunction. If hypoxia is severe or persistent, it will inevitably lead to desaturation of blood samples in multiple organs, eventually leading to multiple organ dysfunction syndrome. In an animal model, simulated high-altitude hypoxia (0.9% for 24 hours) was able to cause pulmonary edema, inflammation, and hemorrhage in rats, accompanied by cerebral edema, hippocampal oxidative stress, and cognitive dysfunction. As more and more people work, travel and live in high altitude areas, how to effectively prevent hypoxic injury has attracted more and more attention. The clinical diagnosis of acute...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/577G01N33/558
CPCG01N33/558G01N33/577
Inventor 赵名朱玲玲成祥赵彤范明周延召韩莹李改芬
Owner ACADEMY OF MILITARY MEDICAL SCI
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