Method for purifying aesculin

The technology of a patinol and its purification method, which is applied in the field of medicine, can solve the problems of complicated collection operation, low crystallization purity, and low collection rate, and achieve the effects of simple process, good purity, and high yield

Inactive Publication Date: 2019-01-04
宁县恒瑞康生物科技有限公司
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Problems solved by technology

[0003] The present invention provides a method for purifying echinocetin, aiming at solving the problems of complex eluting segmented collection operation with methanol with different alcohol degrees, low collection rate, unfavorable production, low crystallization purity and low yield in the existing process

Method used

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Embodiment Construction

[0020] A method for purifying patinol, which is characterized in that: (1) pulverizing pachyrhiza material, sieving, putting into a heat reflux extractor, adding the extract to reflux extraction at a certain temperature, discarding the residue, and passing the extract through Collect the filtrate after the filter, and after the filtrate is concentrated in a pressurized concentration tank, cool to room temperature for later use; (2) Put the obtained concentrated solution into the storage tank, add a clarifier with a certain proportion of the solution volume, stir fully, place the crystallization, and filter the crystallization , to obtain the crude product I of peretrin; filter the mother liquor for later use. (3) Put the macroporous resin into the chromatographic column for later use, activate the macroporous resin, wash it with water, absorb the standby filtered mother liquor in step (2) to the macroporous resin column, elute the column, and collect the eluent for subsequent u...

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Abstract

The invention discloses a method for purifying aesculin. The method comprises the following steps: drying and crushing Chinese ash roots; refluxing and extracting; combining extracts; abandoning material residues; concentrating the extract obtained in the step until no alcohol is left; placing the concentrate for crystallization; filtering and crystallizing; applying mother liquor to macroporous resin; respectively eluting with methanol with different alcohol degrees; collecting eluents with different alcohol degrees; concentrating the eluents; placing the concentrated eluent for crystallization; collecting all crystals together; adding new methanol for dissolving at 60 DEG C; filtering with a silica gel alumina column; collecting filtrate; concentrating and placing for crystallization; filtering crystals; drying the crystals and then adding purified water for dissolving at 95 DEG C for filtration; placing the filtrate for crystallization, wherein the crystals are aesculin and the content can reach 99%. Compared with the prior art, the method has advantages of high yield, good purity, short production period, simple process, safer operation and availability of high-purity aesculin.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a method for purifying fencortin. Background technique [0002] The existing extraction process of Qinpi in China mainly includes two steps of extraction and separation of raw materials of Qinpi. In the existing technology, the operation of extraction and elution in separation is complex, the collection rate is low, it is not conducive to production, the purity of crystallization is low, and the yield is low. Contents of the invention [0003] The present invention provides a method for purifying echinocetin, aiming at solving the problems of complex eluting segmented collection operation with methanol with different alcohol degrees, low collection rate, unfavorable production, low crystallization purity and low yield in the existing process . [0004] The technical scheme of the invention is: a method for purifying fencutin, characterized in that: [0005] (1) ...

Claims

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Application Information

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IPC IPC(8): C07H17/075C07H1/08
CPCC07H1/08C07H17/075
Inventor 吴丽君张丽娟李建林杨仲科
Owner 宁县恒瑞康生物科技有限公司
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