Preparation method and applications of aggregation-induced emission probe material

A technology of aggregation-induced luminescence and probes, which is applied to luminescent materials, material analysis by optical means, and material analysis, etc., can solve the problems of drug detection being easily affected by external conditions, long detection time, and cumbersome detection. Enhanced sensitivity, enhanced fluorescence performance, the effect of excellent fluorescence performance

Active Publication Date: 2019-01-01
ZHEJIANG UNIV OF TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to overcome the problems in the prior art that drug detection is easily affected by external conditions, the detection is cumbersome, and the detection takes a long time, and provides a drug detection device that is not affected by external conditions, simple detection, and short detection time. aggregation-induced luminescence probe

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  • Preparation method and applications of aggregation-induced emission probe material
  • Preparation method and applications of aggregation-induced emission probe material
  • Preparation method and applications of aggregation-induced emission probe material

Examples

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Embodiment 1

[0027] A method for preparing an aggregation-induced luminescent probe material, comprising the following steps:

[0028] 1) Add 1.6g of monocarboxyl oligomeric silsesquioxane and 100mL N,N-dimethylformamide into a round bottom flask, stir and dissolve to obtain carboxylated oligomeric silsesquioxane solution;

[0029] 2) Add 0.7g of 4-dimethylaminopyridine and 0.9g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride to the carboxylated oligomeric silsesquioxane solution salt and 2.7g triethylamine, stirred in an ice-water bath for 1h to obtain a mixed solution;

[0030] 3) Add 2g of 1-hydroxypentaphenylsilole to the mixed solution, and keep it warm for reaction. The keep warm reaction temperature is 20°C, and the reaction time is 24h. Pour the solution obtained after the reaction into 500mL distilled water, and stir to get a white precipitate ;

[0031] 4) A white precipitate was obtained after suction filtration with a Buchner funnel. The precipitate was washed ...

Embodiment 2

[0037] A method for preparing an aggregation-induced luminescent probe material, comprising the following steps:

[0038] 1) Add 1.9g octacarboxyl oligomeric silsesquioxane and 100mL N,N-dimethylformamide into a round bottom flask, stir and dissolve to obtain carboxylated oligomeric silsesquioxane solution;

[0039] 2) Add 0.8g of 4-dimethylaminopyridine and 1g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride to the carboxylated oligomeric silsesquioxane solution and 2.8g triethylamine, stirred in an ice-water bath for 1h to obtain a mixed solution;

[0040] 3) Add 3.9g of 1-aminotetraphenylethylene to the mixture, and keep it warm for reaction. The keep warm reaction temperature is 20°C, and the reaction time is 24h. Pour the solution obtained after the reaction into 500mL of distilled water, and stir to get a white precipitate ;

[0041]4) A white precipitate was obtained after suction filtration with a Buchner funnel. The precipitate was washed with acetonit...

Embodiment 3

[0047] A method for preparing an aggregation-induced luminescent probe material, comprising the following steps:

[0048] 1) Add 1.7g of monocarboxyl oligomeric silsesquioxane and 110mL N,N-dimethylformamide into a round bottom flask, stir and dissolve to obtain carboxylated oligomeric silsesquioxane solution;

[0049] 2) Add 0.75g of 4-dimethylaminopyridine and 1g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride to the carboxylated oligomeric silsesquioxane solution and 2.8g triethylamine, stirred in an ice-water bath for 1.5h to obtain a mixed solution;

[0050] 3) Add 3g of 1-hydroxypentaphenylsilole to the phase mixture, and keep it warm for reaction. The keep warm reaction temperature is 22°C, and the reaction time is 25h. Pour the solution obtained after the reaction into 550mL distilled water, and stir to get a white precipitate ;

[0051] 4) A white precipitate was obtained after suction filtration with a Buchner funnel. The precipitate was washed with ...

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Abstract

The invention relates to the technical field of drug detection, and discloses a preparation method and applications of an aggregation-induced emission probe material. The preparation method comprises:1) dissolving carboxylated oligomeric silsesquioxane in N,N-dimethylformamide; 2) adding 4-dimethylaminopyridine, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and triethylamine, and stirring in an ice water bath; 3) adding 1-hydroxypentaphenylsilole or 1-aminotetraphenylethylene, carrying out a thermal insulation reaction, adding to distilled water, and stirring to obtain a white precipitate; and 4) carrying out suction filtration, and washing to obtain the aggregation-induced emission probe material. According to the present invention, the aggregation-induced emission probe material is not affected by the external conditions in drug detection, and further has advantages of simple detection and short detection time.

Description

technical field [0001] The invention relates to the technical field of drug detection, in particular to a preparation method and application of an aggregation-induced luminescent probe material. Background technique [0002] The proliferation and prevalence of drugs has caused great harm to our society, and the containment of drug crimes has always been a global concern. According to Article 357 of the "Criminal Law of the People's Republic of China", drugs refer to opium, heroin, methamphetamine (ice), morphine, marijuana, cocaine, and other narcotic drugs and psychotropic substances controlled by the state that can make people addicted . According to the natural properties of drugs, drugs can be divided into two categories: narcotic drugs and psychotropic drugs. It has an anesthetic effect on the central nervous system, and continuous use of narcotic drugs that are prone to physical dependence, such as opiates; directly acts on the central nervous system to excite or inh...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F7/21C09K11/06G01N21/64
CPCC07F7/21C09K11/06C09K2211/1007C09K2211/1096G01N21/6428G01N2021/6432
Inventor 陈思王旭安志杭马猛施燕琴何荟文
Owner ZHEJIANG UNIV OF TECH
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