Preparation method of hemostatic sponge and hemostatic sponge prepared thereby

Abstract

The invention discloses a preparation method of a hemostatic sponge, comprising the following steps: (1) dispersing oxidized cellulose powder into water to obtain 0.1-2.0wt% of oxidized cellulose dispersion, and then homogenizing the oxidized cellulose dispersion under high pressure to obtain a nanooxidized cellulose suspension; (2) injecting the nanooxidized cellulose suspension into a mold, performing 1 to 7 times of freeze-thaw cycles to obtain nanocellulose hydrogel, freezing the nanocellulose hydrogel for sizing, and then drying to obtain the hemostatic sponge; wherein one freeze-thaw process is: freezing for 8-16 h at -40 to -18 DEG C, and then unfreezing for 8-16 h at 4-25 DEG C. The invention also provides the hemostatic sponge prepared by the preparation method. The hemostatic sponge has high carboxyl content, high porosity and water absorption capacity, and can quickly absorb excess blood on the wound surface to achieve effective hemostasis.

Description

technical field [0001] The invention belongs to the field of medical polymer materials, and in particular relates to a preparation method of a hemostatic sponge and a hemostatic sponge prepared by the preparation method. Background technique [0002] Blood is an important carrier for transporting oxygen to the body. When the human body loses too much blood due to injury, the organs and cells will malfunction and fail, which will affect life safety. Uncontrolled hemorrhage has been a major cause of casualties in war or major accidents. In modern warfare, 75% of casualties on the battlefield are caused by explosive fragments and gunshot wounds. Hemorrhage is still the main cause of death in battlefield trauma. Effective hemostasis can greatly reduce the mortality rate of trauma. Due to the protective effect of personal protective equipment such as bulletproof vests and helmets, battlefield trauma often occurs in limbs and limb joints such as armpits, groin, neck, etc. These p...

AI Technical Summary

Problems solved by technology

[0003] Currently reported rapid hemostasis materials mainly include powders (zeolite, collagen powder and potato starch), porous sponges (gelatin sponge, collagen sponge), oxidized regenerated cellulose and fibrin glue, etc., each of which has certain shortcomings: gelatin The tissue adhesion of collagen and collagen is poor, and the hemostatic function of both depends on sufficient platelets and coagulation factors; fibrin is derived from blood, which may cause viral infection; porous zeolite and potato starch absorb water in blood Afterwards, a large amount of heat will be released, which can easily lead to wound inflammation

However, the water absorption rate of the prepared oxidized nanocellulose / collagen composite sponge material decreased by 50% to 60%.

For rapid and massive blood loss, the oxidized nanocellulose / collagen composite sponge material cannot effectively stop bleeding quickly, and its water absorption and swelling effect is poor

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