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Application of herba cistanche based phenylethanoid glycosides to anti-depression

A technology of phenylethanol glycoside and cistanche, which is applied in the field of biomedicine to achieve the effect of simple preparation process

Inactive Publication Date: 2018-12-25
SHANGHAI JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] After searching the existing technology, it was found that Wei Zhenzhen observed the effects of phenylethanol glycosides of Cistanche deserticola on perimenopausal mice, rats and perimenopausal depression mouse models The effects of phenylethanol glycosides of Cistanche deserticola on the treatment of perimenopausal syndrome and its characteristics, but the model used in this paper is a perimenopausal syndrome depression model reproduced by excising the ovaries of female mice combined with chronic stimulation, and its limitations are as follows: The research object is an animal model of female depression induced by perimenopausal estrogen levels
There are currently no published literature on the use of drugs for depression in male mammals

Method used

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  • Application of herba cistanche based phenylethanoid glycosides to anti-depression
  • Application of herba cistanche based phenylethanoid glycosides to anti-depression

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Cistanche deserticola and the preparation technology of each part thereof are as follows

[0033] Cistanche deserticola or Cistanche tubulosa medicinal material is crushed to obtain medicinal material powder; then the medicinal material powder is reflux extracted three times with 10 times the weight of 70% ethanol solution, each time for 2 hours, filtered with three layers of gauze, combined three times with the medicinal solution, and concentrated under reduced pressure to obtain Concentrate. The concentrated solution is separated by macroporous adsorption resin column chromatography, firstly eluted with water to obtain the water eluted part, then eluted with 40% ethanol solution, concentrated each part, and freeze-dried to obtain the water part and 40% ethanol elution site.

Embodiment 2

[0035] Antidepressant pharmacodynamics study of Cistanche deserticola and Cistanche tubulosa and their parts on mouse behavioral hopelessness model.

[0036] The mouse behavioral despair model (mouse tail suspension test, mouse forced swimming test) was used to evaluate the antidepressant effect of the alcohol extracts of Cistanche deserticola and Cistanche tubulosa and their different eluted parts.

[0037] Experimental animals: 135 male ICR mice, weighing 18g-20g.

[0038] Experimental group:

[0039] Experiment 1 group: blank group

[0040] Experimental group 2: 15mg / kg fluoxetine (positive drug)

[0041] Experimental group 3: 15mg / kg imipramine (positive drug)

[0042] Experimental group 4: 2181mg / kg desert Cistanche alcoholic extract

[0043] Experimental group 5: 1112mg / kg Desert Cistanche ethanol extract water elution part

[0044] Experimental group 6: 40% ethanol elution site of 917mg / kg desert cistanche alcoholic extract

[0045] Experimental group 7: 1555mg / kg...

Embodiment 3

[0065] Pharmacodynamic study of extracts from Cistanche cistanche on chronic unpredictable stimuli-induced depression in rat models

[0066] Establish a rat model of depression induced by chronic unpredictable stimuli, and use forced swimming test, sucrose preference test, open field test, and new environment feeding inhibition test to evaluate the antidepressant effect of 40% ethanol-eluted part of Cistanche cistanche ethanol extract effect.

[0067] Experimental animals: 40 male SD rats, weighing 180g-220g.

[0068] Experimental group:

[0069] Experiment 1 group: blank group

[0070] Experiment 2 group: model group

[0071] Experimental group 3: 10mg / kg fluoxetine (positive drug)

[0072] Experiment 4 group: 400mg / kg Cistanche tuberosum alcohol extract 40% ethanol elution site high dose group

[0073] Experimental group 5: 200mg / kg Cistanche cistanche ethanol extract 40% ethanol elution site low dose group

[0074] Experimental method: A total of 40 healthy male clean...

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Abstract

The invention discloses application of herba cistanche based phenylethanoid glycosides to anti-depression. A herba cistanche total extract or herba cistanche phenylethanoid glycoside extract is applied to preparation of anti-depression medicines for male mammals. The herba cistanche extract is an effective component obtained by subjecting herba cistanche powder to liquid reflux extraction to obtain concentrated liquid and subjecting the concentrated liquid to macroporous adsorption resin column chromatography separation. By the effective component prepared from cistanche deserticola and cistanche tubulosa according to an extraction and separation method, the phenylethanoid glycosides have great anti-depression effects and can be applied to preparation and development of anti-depression preparations.

Description

technical field [0001] The invention relates to a technology in the field of biomedicine, in particular to an antidepressant application of phenylethanol glycosides based on Cistanche deserticola. Background technique [0002] Modern pathological studies have shown that because the pathogenesis of depression is complex and there are many causes, it is often difficult to achieve satisfactory curative effect with drugs targeting a single link. Currently, synthetic drugs for the treatment of depression are mainly monoamine oxidase inhibitors, tricyclic antidepressants and serotonin reuptake inhibitors. Although synthetic antidepressants have certain effects, they generally have disadvantages such as narrow antidepressant spectrum, drug resistance, and large toxic and side effects. For example, about 12-15% of patients with depression do not improve their condition after taking antidepressant drugs designed based on the "monoamine neurotransmitter hypothesis", and develop sympt...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/64A61P25/24A23L33/105
CPCA61K36/64A23L33/105A23V2002/00A61P25/24A23V2200/322A23V2250/20
Inventor 李晓波李瑒彭颖郑亮
Owner SHANGHAI JIAOTONG UNIV
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