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Antiaging composition comprising exosome-like vesicles derived from ginseng

A technology of exosomes and compositions, applied in the field of anti-aging compositions, can solve the problems of unreported anti-aging effects of exosome-like membrane structure vesicles

Active Publication Date: 2021-08-10
AMOREPACIFIC CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For ginseng, although the antiaging effects of ginseng-derived extracts or their components have been reported, there is no report on the antiaging effects of ginseng-derived exosome-like membrane-structured vesicles

Method used

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  • Antiaging composition comprising exosome-like vesicles derived from ginseng
  • Antiaging composition comprising exosome-like vesicles derived from ginseng
  • Antiaging composition comprising exosome-like vesicles derived from ginseng

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0089] (Step 1) First, a juice containing ginseng root extracellular juice was prepared by squeezing 4-year-old ginseng roots.

[0090] (Step 2) The juice was centrifuged at 4° C. and 500×g for 10 minutes to obtain a supernatant. Then, the supernatant was centrifuged again at 4° C. and 3,000×g for 20 minutes to obtain a supernatant.

[0091] (Step 3) After adding 0.5 ml of 2.5M sucrose, 1 ml of 0.8M sucrose, and 32 ml of the supernatant from which impurities were removed in order to a 35 ml ultracentrifuge tube, the mixture was ultracentrifuged at 4°C and 100,000×g for 2 Hour. After ultracentrifugation, ginseng root exosome-like vesicles were located between the 2.5M sucrose layer and the 0.8M sucrose layer due to their density. Therefore, the layer containing ginseng root exosome-like vesicles was isolated by removing the solution from the upper part of the tube.

[0092] (Step 4) The separation layer containing ginseng root exosome-like vesicles was subjected to density g...

Embodiment 1

[0106] [Formulation Example 1] Soft capsule

[0107] Mix 50 mg of ginseng-derived exosome-like vesicles, 80-140 mg of L-carnitine, 180 mg of soybean oil, 2 mg of palm oil, 8 mg of hydrogenated vegetable oil, 4 mg of yellow beeswax, and 6 mg of lecithin, and mix each capsule according to common methods. Fill 400 mg to prepare soft capsules.

Embodiment 2

[0108] [Formulation Example 2] Tablet

[0109] 50 mg of ginseng-derived exosome-like vesicles, 200 mg of galacto-oligosaccharide, 60 mg of lactose and 140 mg of maltose were mixed, the mixture was granulated with a fluidized bed dryer, 6 mg of sugar esters were added, and then compressed using a tablet machine to Tablets are prepared.

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Abstract

The present specification discloses an anti-aging composition comprising exosome-like vesicles derived from ginseng as an active ingredient and a method for preparing the composition. The ginseng-derived exosome-like vesicles may have a diameter of 20-500 nm, and may be isolated from ginseng roots, more specifically, from the juice of ginseng roots. By including ginseng-derived exosome-like vesicles as an active ingredient, the composition exhibits anti-aging effects such as improving skin wrinkles, enhancing skin elasticity, and promoting collagen biosynthesis.

Description

technical field [0001] The present disclosure discloses an anti-aging composition comprising exosome-like vesicles derived from ginseng as an active ingredient and a method for preparing the composition. Background technique [0002] Most animal cells have the ability to secrete cell-derived extracellular vesicles of various sizes and compositions. These extracellular vesicles are present in all biological fluids, including blood, urine, saliva, and cell culture media (Loyer X, Vion AC, Tedgui A, Boulanger CM. Microvesicles as cell-cell messengers in cardiovasculardiseases. Circ Res 2014; 114:345-53; Ohno S, Ishikawa A, Kuroda M. Roles of exosomes and microvesicles in disease pathogenesis. Adv Drug Deliv Rev 2013;65:398-401). [0003] Extracellular vesicles are membrane-structured vesicles ranging from about 20 nm to about 5 μm in diameter. They differ in size and composition and contain various species such as exosomes (~30-100 nm), exosomes, microvesicles (~100-1,000 nm)...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/9789A23L33/105A61K8/02A61Q19/08
CPCA61Q19/08A61K8/97A61K8/02A23L33/105
Inventor 崔银廷黄景焕曹恩敬李泰龙
Owner AMOREPACIFIC CORP
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