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Anti-aging composition containing ginseng-derived exosome-like vesicles as active ingredient

A composition and anti-aging technology, applied in cosmetics, food science, cosmetic preparations, etc., can solve problems such as unreported anti-aging effects of exosome-like membrane vesicles

Active Publication Date: 2018-12-21
AMOREPACIFIC CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For ginseng, although the antiaging effects of ginseng-derived extracts or their components have been reported, there is no report on the antiaging effects of ginseng-derived exosome-like membrane-structured vesicles

Method used

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  • Anti-aging composition containing ginseng-derived exosome-like vesicles as active ingredient
  • Anti-aging composition containing ginseng-derived exosome-like vesicles as active ingredient
  • Anti-aging composition containing ginseng-derived exosome-like vesicles as active ingredient

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0089] (Step 1) First, juice containing extracellular fluid of ginseng root was prepared by squeezing 4-year-old ginseng root.

[0090] (Step 2) The juice was centrifuged at 4° C. and 500×g for 10 minutes to obtain a supernatant. Then, the supernatant was centrifuged again at 4° C. and 3,000×g for 20 minutes to obtain a supernatant.

[0091] (Step 3) After sequentially adding 0.5 ml of 2.5M sucrose, 1 ml of 0.8M sucrose, and 32 ml of supernatant from which impurities were removed in a 35 ml ultracentrifuge tube, the mixture was ultracentrifuged at 4°C and 100,000×g for 2 Hour. After ultracentrifugation, ginseng root exosome-like vesicles were located between the 2.5M sucrose layer and the 0.8M sucrose layer due to their density. Therefore, by removing the solution from the upper part of the tube, the layer containing ginseng root exosome-like vesicles was isolated.

[0092] (Step 4) Perform density gradient ultracentrifugation on the separation layer containing exosome-like...

Embodiment 1

[0106] [Preparation Example 1] Soft Capsules

[0107] Mix 50mg of ginseng-derived exosome-like vesicles, 80-140mg of L-carnitine, 180mg of soybean oil, 2mg of palm oil, 8mg of hydrogenated vegetable oil, 4mg of yellow beeswax and 6mg of lecithin, and dispense each capsule according to the usual method Fill 400mg to prepare soft capsules.

Embodiment 2

[0108] [Formulation Example 2] Tablet

[0109] Mix 50 mg of ginseng-derived exosome-like vesicles, 200 mg of galactooligosaccharides, 60 mg of lactose and 140 mg of maltose, granulate the mixture with a fluidized bed dryer, add 6 mg of sugar esters, and then use a tablet machine to compress the Tablets are prepared.

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Abstract

Disclosed in the present specification are: an anti-aging composition containing ginseng-derived exosome-like vesicles as an active ingredient; and a method for preparing the composition. The ginseng-derived exosome-like vesicles can have a diameter of 20 to 500 nm and can be isolated from the roots of ginseng, more particularly, from the juice of the roots of ginseng. The composition exhibits anti-aging effects such as skin wrinkle alleviation, skin elasticity improvement, and collagen biosynthesis promotion by containing ginseng-derived exosome-like vesicles as an active ingredient.

Description

technical field [0001] The present disclosure discloses an anti-aging composition comprising ginseng-derived exosome-like vesicles as an active ingredient and a method for preparing the composition. Background technique [0002] Most animal cells have the ability to secrete cell-derived extracellular vesicles of various sizes and compositions. These extracellular vesicles are present in all biological fluids, including blood, urine, saliva, and cell culture media (Loyer X, Vion AC, Tedgui A, Boulanger CM. Microvesicles as cell-cell messengers in cardiovascular diseases. Circ Res 2014; 114:345-53; Ohno S, Ishikawa A, Kuroda M. Roles of exosomes and microvesicles in disease pathogenesis. Adv Drug Deliv Rev 2013; 65:398-401). [0003] Extracellular vesicles are membrane-structured vesicles with diameters ranging from about 20 nm to about 5 μm. They vary in size and composition and contain various species such as exosomes (approximately 30-100 nm), ectosomes, microvesicles (ap...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A23L33/105A61K8/02A61Q19/08
CPCA61Q19/08A61K8/97A61K8/02A23L33/105
Inventor 崔银廷黄景焕曹恩敬李泰龙
Owner AMOREPACIFIC CORP
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