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Method for preparing epoxydaucenal A and epoxydaucenal B

A technology for carrot and alkenal, applied in the field of chemistry, can solve the problems such as the lack of efficient separation and purification of epoxy carotene aldehyde, and achieve the effect of high-efficiency separation and purification

Active Publication Date: 2018-12-21
滕州鑫和生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is currently no efficient method for the separation and purification of epoxycarotene aldehyde A and B

Method used

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  • Method for preparing epoxydaucenal A and epoxydaucenal B
  • Method for preparing epoxydaucenal A and epoxydaucenal B
  • Method for preparing epoxydaucenal A and epoxydaucenal B

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Embodiment Construction

[0027] The substantive content of the present invention will be described in detail below in conjunction with the embodiments, but the protection scope of the present invention is not limited thereto.

[0028] 1. Experimental materials

[0029] Double roses are the flowers of double roses, which are freshly picked and dried in the shade for later use.

[0030] DA-201 macroporous resin was purchased from Tianjin Haoju Resin Technology Co., Ltd.

[0031] High-speed countercurrent chromatography TEB300B was purchased from Shanghai Tongtian Biotechnology Co., Ltd.

[0032] 2. Experimental methods and results

[0033] Including the following steps:

[0034] Step S1, extraction: pulverize the double-petal roses dried in the shade, extract with 95% ethanol aqueous solution under heat reflux, the solid-to-liquid ratio is 1:20, extract 3 times, each time for 1.5h, filter, and combine the filtrates to concentrate to nothing mellow;

[0035] Step S2, macroporous resin enrichment: pu...

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Abstract

The invention discloses a method for preparing epoxydaucenal A and epoxydaucenal B. The method comprises the following steps: S1, performing extraction: crushing rosa rugosa var. plena Rehd dried in shade, performing extraction, performing filtration, and concentrating filtrate until alcohol taste does not exist; step S2, performing macroporous resin enrichment so as to obtain an enrichment substance freeze-dried powder rich in epoxydaucenal A and epoxydaucenal B; step S3, by using N-hexane / ethyl acetate / 95% ethanol / water in the volume ratio being 9 to 7 to 9 to 7 as a solvent system, performing HSCCC separation and purification so as to obtain the epoxydaucenal A and the epoxydaucenal B, wherein the purity of the epoxydaucenal A is 98.5%, and the purity of the epoxydaucenal B is 98.9%. Through adoption of the method provided by the invention, the epoxydaucenal A and the epoxydaucenal B can be efficiently prepared through separation and purification.

Description

technical field [0001] The invention belongs to the field of chemistry and relates to a method for preparing epoxy carotene aldehydes A and B. Background technique [0002] Epoxycarotenal A and B are two compounds isolated from double-petal roses, and the structural formula is as follows: [0003] [0004] Epoxycarotenal A and B are a pair of isomers, the difference is only in the configuration of the carbon atom connected to the epoxy. [0005] Studies have shown that epoxycarotene aldehydes A and B have a variety of excellent pharmacological activities, and have the value of being developed into a variety of drugs. However, there is currently no efficient method for separating and purifying epoxycarotenal A and B. Contents of the invention [0006] The purpose of the present invention is to overcome the deficiencies of the prior art and provide a method for preparing epoxycarotene aldehydes A and B. [0007] The above object of the present invention is achieved thr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D301/32C07D303/32
CPCC07D301/32C07D303/32
Inventor 郑嘉荣吕学金区伟平
Owner 滕州鑫和生物科技有限公司
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