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Preparation method of hydrophilic coating on guide wire surface of medical catheter, and product of preparation method

A medical catheter and hydrophilic coating technology, applied in catheters, coatings, pharmaceutical formulations, etc., can solve the problems of lack of lasting lubricity, easy residue of organic solvents, complicated steps, etc., to improve the surface performance of catheters, hydrophilic Outstanding lubricity and good biocompatibility

Inactive Publication Date: 2018-12-21
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The publication number is CN102166377A, which discloses a method for preparing and using a hydrophilic coating for medical catheters. The coating is non-cross-linked, and the hydrophilic polymer is easy to fall off and does not have long-lasting lubricity. Moreover, the organic solvent used is easy to remain, which affects its safety and also causes environmental pollution.
The publication number is CN107929819A Chinese Invention Patent Publication discloses a kind of hydrophilic coating for medical metal surface coating, the metal surface is coated with elastic pre-coating and hydrophilic cross-linking layer in turn, although the coating is firm after repeated It does not fall off by friction, but it needs secondary drying and curing. The complicated steps are not conducive to industrial production

Method used

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  • Preparation method of hydrophilic coating on guide wire surface of medical catheter, and product of preparation method
  • Preparation method of hydrophilic coating on guide wire surface of medical catheter, and product of preparation method
  • Preparation method of hydrophilic coating on guide wire surface of medical catheter, and product of preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 1) Weigh 50g of aqueous polyurethane dispersion, dissolve 5g of polyvinylpyrrolidone in 100g of deionized water, add the polyurethane dispersion into the polyvinylpyrrolidone solution, and stir at 30°C for one hour to obtain a uniform solution.

[0030] 2) After adding a few drops of ammonia water to adjust the pH value of the solution to 8-9, weigh 1.5 g of siloxane crosslinking agent and add it to the above solution, stir for 15 minutes, and ultrasonicate for 5 minutes to obtain a homogeneous solution.

[0031] 3) Dip the medical catheter guide wire into the coating solution, wait for 20 seconds, pull out the catheter guide wire at a uniform speed with a puller, and then put it in a 50°C drying oven to dry for 4 hours to obtain a uniform coating.

Embodiment 2

[0033] 1) Weigh 50 g of water-based acrylic resin dispersion, dissolve 3 g of agarose in 100 g of deionized water, add the acrylic acid dispersion into the agarose solution, and stir at room temperature for three hours to obtain a uniform solution.

[0034] 2) After adding a few drops of ammonia water to adjust the pH value of the solution to 8-9, weigh 1.5 g of polyisocyanate crosslinking agent and add it to the above solution, stir for 25 minutes, and sonicate for 10 minutes to obtain a homogeneous solution.

[0035] 3) Dip the medical catheter guide wire into the coating solution, wait for 15 seconds, pull out the catheter guide wire at a uniform speed with a puller, and then put it in an 80°C drying oven to dry for 2 hours to obtain a uniform coating.

Embodiment 3

[0037] 1) Weigh 50 g of water-based polyurethane dispersion, dissolve 8 g of xanthan gum in 100 g of deionized water, add the polyurethane dispersion into the xanthan gum solution, and stir for three hours at room temperature to obtain a uniform solution.

[0038] 2) After adding a few drops of ammonia water to adjust the pH value of the solution to 8-9, weigh 2 g of carbodiimide crosslinking agent and add it to the above solution, stir for 15 minutes, and sonicate for 10 minutes to obtain a homogeneous solution.

[0039] 3) Dip the medical catheter guide wire into the coating solution, wait for 20 seconds, pull out the catheter guide wire at a uniform speed with a puller, and then put it in a 60°C drying oven to dry for 5 hours to obtain a uniform coating.

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Abstract

The invention discloses a preparation method of a hydrophilic coating on a guide wire surface of a medical catheter, and the product of the preparation method. The method comprises the following steps: dissolving aqueous dispersion of resin and hydrophilic polymer(s) in water, mixing and stirring to obtain a uniform solution; adjusting the pH value of the solution, adding crosslinking agent(s), stirring uniformly, and carrying out ultrasonic treatment; immersing a guide wire of the medical catheter into the obtained solution, pulling, curing and drying to form a film; the resin is water-basedamino resin, water-based acrylic resin, water-based epoxy resin, waterborne polyurethane or derivatives thereof; the hydrophilic polymer(s) is / are one or more of polyvinylpyrrolidone, polyvinyl alcohol, xanthan gum, agarose and sodium alginate; the crosslinking agent(s) is / are one or two of a siloxane crosslinking agent, an epoxy crosslinking agent, an aziridine crosslinking agent, a carbodiimidecrosslinking agent and a polyisocyanate crosslinking agent. The coating, prepared by the method, on the guide wire of the medical catheter has good biocompatibility, is simple to operate and easy to implement, beneficial to large-scale production and remarkable in hydrophilic lubrication property.

Description

technical field [0001] The invention belongs to the field of medical materials, and relates to a method for preparing a hydrophilic coating on the surface of a guide wire of a medical catheter and a product thereof. Background technique [0002] The commonly used materials for medical catheters are polyurethane, silicone rubber, latex, etc. The medical guide wire is made of stainless steel, which will cause friction on the tissue during the intervention in the human body, damage the tissue, and increase the pain of the patient. In addition, bacterial adhesion Getting stuck on the catheter guidewire can also cause infection problems. It is a convenient method to apply a hydrophilic coating on the catheter guide wire. The catheter guide wire after the surface hydrophilic treatment can greatly reduce the friction between the human body and the catheter when inserted into the human body, and relieve pain. In addition, the hydrophilic surface is beneficial to prevent the adhesio...

Claims

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Application Information

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IPC IPC(8): A61L29/08A61L29/14
CPCA61L29/08A61L29/085A61L29/14A61L2400/18A61L2420/02A61L2420/06C08L75/04C08L39/06C08L33/08C08L5/12C08L5/00C08L29/04
Inventor 徐福建杨美平段顺丁雪佳
Owner BEIJING UNIV OF CHEM TECH
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