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Preparation method of purpura lapillus anti-inflammatory extract, and application thereof in anti-acne medicine

A technology of lychee snail and extract, applied in the field of lychee snail, can solve the problems of drug dependence, patient side effects, and difficult to cure, and achieve a good effect of treating acne

Inactive Publication Date: 2018-12-18
THIRD INST OF OCEANOGRAPHY STATE OCEANIC ADMINISTATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Frequent use of hormonal drugs can easily lead to drug dependence, which may bring potential side effects to patients
Broad-spectrum antibiotics can easily cause microorganisms such as Propionibacterium acnes to develop drug resistance, making it difficult to cure

Method used

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  • Preparation method of purpura lapillus anti-inflammatory extract, and application thereof in anti-acne medicine
  • Preparation method of purpura lapillus anti-inflammatory extract, and application thereof in anti-acne medicine
  • Preparation method of purpura lapillus anti-inflammatory extract, and application thereof in anti-acne medicine

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Embodiment Construction

[0030] The following embodiments will further illustrate the present invention in conjunction with the accompanying drawings.

[0031] 1) Crack the shell of fresh snails (25kg), retain the soft body, and separate the subbranchial gland, digestive gland and rectal gland tissue on ice (see figure 1 ). Vacuum freeze-dry the gland part for 48 hours to obtain 100 g of dry tissue, which is ground into powder to obtain dried Snail gland powder.

[0032] 2) Take dried snail gland powder (100g) and place it in a brown bottle (protected from light), and divide it with 5L of ethanol / water (80% by volume) or chloroform / methanol (50% by volume) solution Extract at room temperature three times, each time for 24 hours. Combine the three extracts, filter, and concentrate under reduced pressure on a rotary evaporator at 40°C to a dry paste, which is the anti-inflammatory extract of snails.

[0033] The snail anti-inflammatory extract can be used in the preparation of snail anti-acne medicin...

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Abstract

A preparation method of a purpura lapillus anti-inflammatory extract and the application thereof in an anti-acne medicine. The invention relates to purpura lapillus, wherein the preparation method includes: breaking the shells of fresh purpura lapillus and reserving soft bodies; separating hypobranchial gland, digestive gland and rectal gland tissue on ice, and freeze-drying the gland tissues in vacuum to obtain dried tissue, and grinding the dried tissue into powder to obtain dried purpura lapillus gland powder; placing the dried purpura lapillus gland powder in a container, extracting the powder with a solvent and filtering the extract and performing pressure reduced concentration to obtain the purpura lapillus anti-inflammatory extract, which can be applied to prepare an purpura lapillus anti-acne medicine in the dosage forms such as spray, ointment, cream, gels and the like. With the edible purpura lapillus being an extraction raw material of the medicine, the medicine is natural and safe. The purpura lapillus anti-inflammatory extract is proved to have excellent effect of treating the acnes in an animal experiment. By means of the various dosage forms with the purpura lapillusanti-inflammatory extract being a main active component, the products can be conveniently designed for different administration objects in different dosage forms.

Description

technical field [0001] The invention relates to snails, in particular to a preparation method of snail anti-inflammatory extract and its application in anti-acne medicine. Background technique [0002] Acne is a chronic inflammatory skin disease that occurs in the pilosebaceous glands, and the prevalence rate is as high as 70%. Acne not only affects the appearance, but when it is severe, the scars left behind can easily cause psychological diseases such as anxiety, low self-esteem, and even depression in patients, and affect patients' social emotions and interpersonal relationships. [0003] The pathogenesis of acne is complex, and it is generally believed that it is related to abnormal regulation of sebum secretion by androgen, abnormal keratinization, infection of Propionibacterium acnes, and inflammatory response ([1] Shen Wentong, He Xiang, Zhang Huimin, Antibacterial effect of plant ingredients on acne bacillus Progress in the study of its role (Journal of Liaoning Uni...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/618A61K9/12A61K47/44A61K9/06A61P17/10
CPCA61K9/0014A61K9/06A61K9/12A61K35/618A61K47/44A61P17/10
Inventor 张芳王昭凯杨隆河胡凡吴鹏陈水波
Owner THIRD INST OF OCEANOGRAPHY STATE OCEANIC ADMINISTATION
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