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Mesoporous silica and cellulose blended membrane dually protected by carbonate and suffer solution as well as preparation method and application of mesoporous silica and cellulose blended membrane

A technology of mesoporous silica and buffer solution, applied in chemical instruments and methods, bandages, water/sludge/sewage treatment, etc., can solve the problem of destroying the surface and pore structure of high specific surface area, and losing the ability to be used as a drug carrier and other problems, to achieve good repeatability, accelerate the growth of epithelial cells, and reduce the frequency of dressing replacement

Active Publication Date: 2018-12-14
WUHAN INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although mesoporous silica has the above-mentioned multiple advantages, and is relatively easy to prepare, some of them have been successfully industrialized, but because they are acidic oxides, they are known to be the cheapest, most environmentally friendly, and easiest to prepare cellulose. Under the alkali / urea solvent system, their high specific surface area surface and pore structure will be destroyed by strong alkali, so that they will lose their ability to serve as drug carriers. Therefore, it is desired to make mesoporous silica and cellulose porous film Combining and loading drugs to form a dual controlled release of drugs and long-term release of drugs, some methods must be used to protect the surface and pores of mesoporous silica

Method used

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  • Mesoporous silica and cellulose blended membrane dually protected by carbonate and suffer solution as well as preparation method and application of mesoporous silica and cellulose blended membrane
  • Mesoporous silica and cellulose blended membrane dually protected by carbonate and suffer solution as well as preparation method and application of mesoporous silica and cellulose blended membrane
  • Mesoporous silica and cellulose blended membrane dually protected by carbonate and suffer solution as well as preparation method and application of mesoporous silica and cellulose blended membrane

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A method for preparing a membrane by blending mesoporous silica and cellulose, the specific steps are as follows:

[0032] 1) Configure CaCl with a mass fraction of 10% respectively 2 and 10% Na 2 CO 3 solution;

[0033] 2) Disperse the SBA-15 particles in the CaCl prepared in step 1) 2 solution, soaked for 48h, and then mixed with the Na prepared in step 1) 2CO 3 Solution mixing, mechanical stirring for 2 hours, SBA-15 particles and CaCl 2 The mass ratio is 1:2;

[0034] 3) The turbid liquid obtained in step 2) was repeatedly centrifuged and washed to remove the salt, and finally placed in an oven to dry to generate blocky calcium carbonate-wrapped SBA-15 particles, which were ground into fine powder;

[0035] 4) Prepare 0.5mol / L phosphate buffer solution (pH=6.0), disperse the fine powder obtained in step 3) in it and soak for 48 hours, and pre-cool to -5°C;

[0036] 5) Prepare cellulose solvent, pre-cool to -12°C, then add a certain amount of cellulose, stir ...

Embodiment 2

[0042] A method for preparing a membrane by blending mesoporous silica and cellulose, the specific steps are as follows:

[0043] 1) Configure CaCl with a mass fraction of 10% respectively 2 and 10% Na 2 CO 3 solution;

[0044] 2) Disperse the SBA-15 particles in the CaCl prepared in step 1) 2 solution, soaked for 72h, and then mixed with the Na prepared in step 1) 2 CO 3 The solution was mixed and mechanically stirred for 3 hours, and the SBA-15 particles and CaCl 2 The mass ratio is 1:5;

[0045] 3) The turbid liquid obtained in step 2) was repeatedly centrifuged and washed to remove the salt, and finally placed in an oven to dry to generate blocky calcium carbonate-wrapped SBA-15 particles, which were ground into fine powder;

[0046] 4) Prepare 0.2mol / L phosphate buffer solution (pH=6.0), disperse the fine powder obtained in step 3) in it and soak for 72 hours, and pre-cool to -3°C;

[0047] 5) Prepare cellulose solvent, pre-cool to -12°C, then put in a certain am...

Embodiment 3

[0053] A method for preparing a membrane by blending mesoporous silica and cellulose, the specific steps are as follows:

[0054] 1) Configure CaCl with a mass fraction of 10% respectively 2 and 10% Na 2 CO 3 solution;

[0055] 2) Disperse the MCM-41 particles in the CaCl prepared in step 1) 2 solution, soaked for 96h, and then mixed with the Na prepared in step 1) 2 CO 3 The solution was mixed and mechanically stirred for 3 hours, MCM-41 particles and CaCl 2 The mass ratio is 1:5;

[0056] 3) The turbid liquid obtained in step 2) was repeatedly centrifuged and washed to remove the salt, and finally placed in an oven to dry to generate massive calcium carbonate-wrapped MCM-41 particles, which were ground into fine powder;

[0057] 4) Prepare 0.1mol / L citric acid-sodium citrate buffer solution (pH=6.4), disperse the fine powder obtained in step 3) in it and soak for 72 hours, and pre-cool to -1°C;

[0058] 5) Prepare cellulose solvent, pre-cool to -12°C, then add a cert...

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Abstract

The invention discloses a mesoporous silica and cellulose blended membrane dually protected by carbonate and a suffer solution as well as a preparation method and application of the mesoporous silicaand cellulose blended membrane. The blended membrane disclosed by the invention is prepared by molding a casting solution and contains the buffer solution, alkaline earth metal or transition metal carbonate, mesoporous silica and a cellulose solvent, and the range of the pH value of the buffer solution is 4.0-10.1. The method disclosed by the invention comprises the following steps: (1) dispersingmesoporous silica particles into a suspension liquid containing alkaline earth metal or transition metal carbonate; (2) adding the suspension liquid in the step (1) into the buffer solution, and then, mixing with a precooled cellulose solution to obtain the casting solution; and (3) calendering the casting solution prepared in the step (2) to obtain the blended membrane. The cellulose solution isblended with mesoporous silica coated by carbonate, both the buffer solution and a low temperature play a role in protecting the inner and outer surfaces of mesoporous silica, and finally, a dressingis prepared by using a calendaring method. The related preparation method is simple and easy.

Description

technical field [0001] The invention relates to the technical field of functional polymer materials, in particular to a mesoporous silicon dioxide and cellulose blend membrane double-protected with carbonate and buffer solution, its preparation method and application. Background technique [0002] As a covering for wounds, medical dressings can replace damaged skin to act as a temporary barrier during wound healing, avoid or control wound infection, and provide an environment conducive to wound healing. Along with the increase of diabetic patient and chronic ulcerative wound, the market value of medical dressing also becomes more and more important. In the second half of the 19th century, the surgeon Gamgee invented the absorbent and antibacterial Gamgee dressing, a cotton pad. Since Dr. George Winter, a British scientist, discovered that a humid environment is beneficial to wound healing in 1962, and put forward the "moist wound healing theory", people have made breakthrou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L1/02C08K9/10C08K7/26C08J5/18C02F1/28A61L15/42A61L15/44A61L15/46A61L15/18A61L15/28C02F101/20
CPCA61L15/18A61L15/28A61L15/42A61L15/425A61L15/44A61L15/46A61L2300/404A61L2300/602C02F1/288C02F2101/20C08J5/18C08J2301/02C08K7/26C08K9/10C08L1/02
Inventor 喻发全沈陟薛亚楠王建芝蔡宁谌伟明
Owner WUHAN INSTITUTE OF TECHNOLOGY
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