A kind of anticoagulant hemodialysis membrane and preparation method thereof

A technology of hemodialysis and anticoagulation, applied in the direction of semipermeable membrane separation, chemical instruments and methods, membranes, etc., can solve the problems of reduced dialysis efficiency and affecting the life safety of dialysis patients, so as to improve the effect of hemodialysis and equipment dependence The effect of low cost and easy availability of raw materials

Active Publication Date: 2020-05-19
苏州肺盾医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The appearance of blood coagulation will reduce the efficiency of dialysis and even affect the life safety of dialysis patients

Method used

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  • A kind of anticoagulant hemodialysis membrane and preparation method thereof

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Embodiment 1

[0030] A preparation method of an anticoagulant hemodialysis membrane, comprising the steps of:

[0031] Ⅰ Preparation of polysulfone amide polycondensate: 32.5 g of bis[4-(4-aminophenoxy)phenyl] sulfone and 10 g of aspartic acid were dissolved in 100 g of dimethyl sulfoxide to form a solution, and the solution was prepared under normal pressure at 150 ℃ for 2.5 hours, then add 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride 8g, 4-dimethylaminopyridine 4g, 1-butyl-3-methanol to the solution 2 g of imidazole trifluoroacetate, heat up to 190°C, conduct the primary polycondensation reaction for 3 hours, then transfer the reaction liquid into the reaction kettle, vacuumize (500Pa), heat to 230°C, and conduct the polycondensation reaction for 8 hours, then place in water Settled out, and then placed in a vacuum drying oven at 98 ° C for 15 hours to obtain a polysulfone amide polycondensate;

[0032] II Dimethyl (3-chloro-2-oxopropyl) phosphonate exchange: Dimethyl (3-chl...

Embodiment 2

[0038]A preparation method of an anticoagulant hemodialysis membrane, comprising the steps of:

[0039] Ⅰ Preparation of polysulfone amide polycondensate: Dissolve 32.5g of bis[4-(4-aminophenoxy)phenyl]sulfone and 10g of aspartic acid in 115g of N,N-dimethylformamide to form a solution , reacted at 155°C under normal pressure for 2.8 hours, then added 8 g of 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride, 4 g of 4-dimethylaminopyridine, tetrabutyl Ammonium bromide 2g, warming up to 195°C, primary polycondensation reaction for 3.5 hours, then the reaction solution is transferred to the reactor, vacuumed (500Pa), heated to 235°C, polycondensation reaction for 8.5 hours, and then precipitated in water, and then Place it in a vacuum drying oven at 98°C for 15 hours to obtain a polysulfone amide polycondensate;

[0040] II Dimethyl (3-chloro-2-oxopropyl) phosphonate exchange: Dimethyl (3-chloro-2-oxopropyl) phosphonate 23g, hydroxyethyl methylcellulose 7g Join in the ...

Embodiment 3

[0046] A preparation method of an anticoagulant hemodialysis membrane, comprising the steps of:

[0047] Ⅰ Preparation of polysulfone amide polycondensate: Dissolve 32.5 g of bis[4-(4-aminophenoxy)phenyl] sulfone and 10 g of aspartic acid in 125 g of N-methylpyrrolidone to form a solution. React at 160°C for 2.9 hours, then add 8 g of 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride, 4 g of 4-dimethylaminopyridine, 1,2-dimethyl - 2g of 3-hydroxyethylimidazole hexafluorophosphate, heat up to 200°C, conduct primary polycondensation reaction for 4 hours, then transfer the reaction solution into the reactor, vacuumize (500Pa), heat to 240°C, and conduct polycondensation reaction for 9 hours , and then precipitated in water, and then placed in a vacuum drying oven at 98 ° C for 15 hours to obtain a polysulfone amide polycondensate;

[0048] II Dimethyl (3-chloro-2-oxopropyl) phosphonate exchange: Dimethyl (3-chloro-2-oxopropyl) phosphonate 25g, hydroxyethyl methylcellulo...

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Abstract

The invention discloses a preparation method of an anticoagulant hemodialysis membrane. The preparation method comprises the following steps of (1) preparation of polysulfone amide polycondensate; (2)ester exchange of dimethyl(3-chloro-2-oxypropyl)phosphonate ester; (3) ionizing of the polysulfone amide polycondensate; (4) ion exchange; (5) forming of the membrane. The invention also discloses the anticoagulant hemodialysis membrane prepared by the preparation method. The anticoagulant hemodialysis membrane has the advantages that the anticoagulant property is realized, the biocompatibility is good, the water permeability and ultrafiltration rate are high, the clearing rate of toxin is high, and the mechanical property is excellent.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to an anticoagulant hemodialysis membrane and a preparation method thereof. Background technique [0002] Hemodialysis is an effective alternative therapy for the treatment of acute and chronic renal failure. Clinically applied hemodialysis equipment consists of a dialysis machine, a water treatment system, a dialysate system and a dialyzer. Among them, the performance of the dialyzer directly affects the dialysis effect, and the hemodialysis membrane is the main part that determines the performance of the dialyzer. It uses the principle of a semi-permeable membrane and uses the solute gradient, osmotic gradient and water pressure gradient on both sides of the membrane to achieve It is a membrane material for the purpose of removing toxins and excessive water retention in the body, replenishing the substances needed in the body, and maintaining electrolyte and acid-base...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D71/76B01D69/02B01D67/00
CPCB01D67/0002B01D69/02B01D71/76B01D2325/36
Inventor 朱露晶万迎春朱水寿
Owner 苏州肺盾医疗科技有限公司
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