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Composition for treating postherpetic neuralgia and preparation method thereof

A composition and drug technology, applied in the field of medicine, can solve the problems of large damage to patients and intolerance of patients

Active Publication Date: 2018-12-11
GENERAL HOSPITAL OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, subcutaneous injection is more harmful to patients, and patients cannot tolerate it in many cases

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0095] Embodiment 1: preparation composition of the present invention

[0096] Formula (per 100g): 4.05g methylene blue, 4.10g ropivacaine, 6.25g absolute ethanol, 0.25g propylene glycol, 0.85g menthol, 0.50g eucalyptus oil, 0.25g polysorbate 80, 0.15g Methyl p-hydroxybenzoate, 7.50g glycerin, 3.05g sodium polyacrylate, 3.05g sodium carboxymethylcellulose, 0.09g dihydroxy aluminum glycinate, 0.10g aluminum hydroxide, 3.45g polyacrylic acid, 1.11g kaolin, added to full amount of water.

[0097] preparation:

[0098] (1) Weigh methylene blue, ropivacaine, absolute ethanol, propylene glycol, menthol, eucalyptus oil, polysorbate 80, and paraben in a container and mix them in a container at 60°C Heat and stir (about 3 hours) until it dissolves into a homogeneous solution, set aside;

[0099] (2) In another container, add glycerin with half the amount of the prescription, sodium polyacrylate with half the amount of the prescription, and sodium carboxymethyl cellulose with half ...

Embodiment 2

[0103] Embodiment 2: preparation composition of the present invention

[0104] Formula (per 100g): 3g methylene blue, 6g ropivacaine, 4g absolute ethanol, 0.5g propylene glycol, 0.5g menthol, 0.8g eucalyptus oil, 0.1g polysorbate 80, 0.25g p-hydroxybenzene Ethyl formate, 5g glycerin, 5g sodium polyacrylate, 1g sodium carboxymethyl cellulose, 0.15g dihydroxyaluminum glycinate, 0.05g aluminum hydroxide, 5g polyacrylic acid, 0.5g kaolin, add to the full amount of water.

[0105] preparation:

[0106] (1) Weigh methylene blue, ropivacaine, absolute ethanol, propylene glycol, menthol, eucalyptus oil, polysorbate 80, and paraben in a container and mix them in a container at 40°C Heat and stir (about 2 hours) until it dissolves into a homogeneous solution, set aside;

[0107] (2) In another container, add glycerin with half the amount of the prescription, sodium polyacrylate with half the amount of the prescription, and sodium carboxymethyl cellulose with half the amount of the p...

Embodiment 3

[0111] Embodiment 3: preparation composition of the present invention

[0112] Formula (per 100g): 6g methylene blue, 3g ropivacaine, 9g absolute ethanol, 0.1g propylene glycol, 1.25g menthol, 0.2g eucalyptus oil, 0.5g polysorbate 80, 0.05g p-hydroxybenzene Propyl formate, 10g glycerin, 1g sodium polyacrylate, 5g sodium carboxymethylcellulose, 0.05g dihydroxyaluminum glycinate, 0.15g aluminum hydroxide, 2g polyacrylic acid, 1.5g kaolin, add to full amount of water.

[0113] preparation:

[0114] (1) Weigh methylene blue, ropivacaine, absolute ethanol, propylene glycol, menthol, eucalyptus oil, polysorbate 80, and paraben in a container and mix them in a container at 45°C Heat and stir (about 3 hours) until it dissolves into a homogeneous solution, set aside;

[0115] (2) In another container, add glycerin with half the amount of the prescription, sodium polyacrylate with half the amount of the prescription, and sodium carboxymethyl cellulose with half the amount of the pre...

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PUM

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Abstract

The invention relates to a composition for treating postherpetic neuralgia and a preparation method thereof. The composition contains methylene blue and ropivacaine. Specifically, the invention further relates to a method for treating the postherpetic neuralgia. The method comprises the step that an effective amount of a pharmaceutical composition containing the methylene blue and the ropivacaineis applied on skin of a pain part of a subject in need, wherein the weight ratio of the methylene blue to the ropivacaine is 1:0.5-2. The pharmaceutical composition is an externally-applied medicinalpreparation for transdermal administration, such as gel emplastrum and cataplasm. The composition and method for treating the postherpetic neuralgia has the advantages that the method is simple and convenient to use, injection and trauma are avoided, almost no side effects are caused, the safety and the effectiveness are achieved, and the tolerance is good.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a composition for treating postherpetic neuralgia and a preparation method thereof. The composition can be simply and effectively used for treating postherpetic neuralgia. In particular, the composition of the invention comprises methylene blue and ropivacaine. Background technique [0002] Herpes zoster is an acute skin disease caused by the varicella-zoster virus. Children who are not immune to it will develop chickenpox after being infected, and some people will not develop chickenpox, which is a recessive infection and carries the virus. The virus is neurotropic, invades the sensory nerve endings of the skin, transfers to the dorsal root ganglia of the spinal cord along the nerve fibers, and hides there. Resurrection causes ganglion inflammation and necrosis, and the virus can move along the nerve fibers to the skin to cause herpes and pain; the older you are, the more severe...

Claims

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Application Information

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IPC IPC(8): A61K31/5415A61K9/70A61P25/02A61P31/22A61K31/445
CPCA61K9/7061A61K31/445A61K31/5415A61P25/02A61P31/22A61K2300/00
Inventor 徐风华孙畅孙永海
Owner GENERAL HOSPITAL OF PLA
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