A human body safe and degradable microneedle array and its manufacturing method and mold

Abstract

The invention proposes a human body safe and degradable microneedle array, a manufacturing method and a mold thereof. The microneedle array includes a substrate and a plurality of microneedles arranged at predetermined intervals on the substrate, each microneedle includes a needle head and a needle body connected to each other, the needle head is tapered, and the needle body One end is connected to the substrate, and the other end of the needle is connected to the wide end of the needle. Microneedle arrays are prepared by thermal injection of human body-safe and degradable polymer thermoplastic materials in the mold. The microneedle arrays penetrate through the skin and contact body fluids, which can realize the functions of in-situ detection and drug delivery. The unique structure of the barb It can be realized that after the substrate is removed, the needle can remain subcutaneously for a long time, continue to maintain the drug delivery or detection function, and finally realize safe degradation in the human body.

Description

technical field [0001] The invention relates to the field of medical equipment, in particular to a human body-safe and degradable microneedle array, a manufacturing method and a mold thereof. Background technique [0002] As a new painless transdermal drug delivery technology, microneedle drug delivery made of biodegradable materials can painlessly create micron-scale drug delivery channels on the skin, and enhance the skin's response to active substances or drugs, especially macromolecules. Drug permeability. Due to the painless, safe, and easy-to-operate advantages of human-safe degradable microneedle drug delivery technology, it is the future development direction of drug delivery through the skin to the body to achieve treatment and diagnosis. [0003] The height of the microneedles used in microneedle drug delivery technology is generally between 50 microns and 1000 microns, which can penetrate the stratum corneum of the skin with natural protection (usually only 10 mi...

AI Technical Summary

Problems solved by technology

[0004] During the actual use of microneedles, the microneedles must be continuously pressured to fit on the skin surface, and at the same time, the skin in the corresponding area must not be deformed too much. Before the microneedles finally dissolve, they must remain in close contact with the skin. This process It will last for one to two hours, often resulting in insufficient injection volume, or sticking the microneedle tape on the body surface for a long time, resulting in unsightly appearance, which is not conducive to the use of patients

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