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Uses of ethyl gallate

A technology of ethyl gallate and its use, which is applied in the field of medicine to achieve the effect of improving intestinal function, wide application prospects, and reducing the rate of loose stools

Inactive Publication Date: 2018-11-30
SHANGHAI UNIV OF ENG SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, there are relevant reports on the treatment of cancer with ethyl gallate, but so far, there is no relevant report on the treatment of diarrhea with ethyl gallate

Method used

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  • Uses of ethyl gallate
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1: investigate the effect of ethyl gallate on diarrhea

[0022] 1.1 Experimental medicinal materials and reagents and animals:

[0023] Powerlab biological signal acquisition system (AD-Intruments company); loperamide hydrochloride capsules (Xi’an Janssen Pharmaceutical Co., Ltd.); (Shanghai Shangxi Weikang (Shangqiu) Pharmaceutical Products Co., Ltd.) The rest of the materials are commercially available brand products.

[0024] Weigh 30g of senna leaves, heat and reflux for 10 minutes, then concentrate under reduced pressure to 100mL to obtain 0.3g / mL crude drug senna liquid; weigh 20g of magnesium sulfate to make 0.4000g / mL liquid; Into 2.1428mg / kg solution.

[0025] Kunming mice, SPF grade, 20±2 g, provided by Hunan Slake Jingda Experimental Animal Co., Ltd., certificate number SCXK (Xiang) 2013-0004. Free to drink and eat, 12 rats per cage, used for experiment after 4 days of adaptive feeding. No food or water was allowed 12 hours before the experimen...

Embodiment 2

[0052] Embodiment 2: investigate the effect of ethyl gallate on diabetic gastrointestinal dysfunction

[0053] 2.1 Main medicines, reagents and instruments:

[0054] Streptozotocin (STZ, Sigma Company of the United States), mosapride (Lunan Beite Pharmaceutical Co., Ltd.), motilin and gastrin radioimmunoassay kits were purchased from Beijing Huaying Institute of Biotechnology, and gall Ethyl acetate (Chengdu Ruifensi Biotechnology Co., Ltd.), blood glucose meter and test strips: provided by Aikang Biotechnology (Hangzhou) Co., Ltd.

[0055] 2.2 Experimental animals:

[0056] Healthy adult SPF grade Kunming rats (200±2g) were purchased from Hunan Slack Jingda Experimental Animal Co., Ltd., certificate number SCXK (Xiang) 2013-0004.

[0057] 2.3 Establishment of diabetes model:

[0058] After the experimental rats were fed adaptively for one week, they were fasted without water for 12 hours before the experiment, and the rats in the diabetic group were intraperitoneally injec...

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PUM

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Abstract

The invention discloses uses of ethyl gallate, particularly uses of ethyl gallate as the active component or the only active component in preparation of anti-diarrheal drugs. According to the presentinvention, the research results show that the ethyl gallate can significantly inhibit the contraction of the isolated intestinal smooth muscle of mice, significantly reduce the mouse loose stool rate,significantly reduce the motilin level and the gastrin level in the blood serum of diabetic rats, and improve the intestinal function, such that the ethyl gallate has significant anti-diarrheal effect, can be expected to be used as the active component for the preparation of anti-diarrheal drugs, can be especially expected to be used for preparing drugs for treatment of diarrhea or diabetic gastrointestinal disorders, and has wide application prospects.

Description

technical field [0001] The invention relates to a use of ethyl gallate, which belongs to the field of medicine. Background technique [0002] Diarrhea is a common symptom, which refers to the frequency of defecation significantly exceeding the frequency of usual habits, thin fecal matter, increased water content, daily defecation volume exceeding 200g, or containing undigested food or pus, blood, and mucus. Diarrhea is often accompanied by symptoms such as urgency to defecate, anal discomfort, and incontinence. At present, diarrhea mainly includes acute diarrhea and chronic chronic. Acute diarrhea has a sharp onset and the course of the disease is within 2 to 3 weeks. Chronic diarrhea refers to recurrent diarrhea with a course of more than two months or an intermittent period within 2 to 4 weeks. [0003] Gastrointestinal dysfunction in diabetes is one of the common complications of diabetes, which is caused by gastrointestinal dysfunction caused by diabetes damage to nerv...

Claims

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Application Information

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IPC IPC(8): A61K31/235A61P1/12A61P1/00A61P3/10
CPCA61K31/235A61P1/00A61P1/12A61P3/10
Inventor 尹小英王晗刘晓会
Owner SHANGHAI UNIV OF ENG SCI
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