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Preparation and application of novel near-infrared two-zone organic small-molecule fluorescent probe

A fluorescent probe and near-infrared technology, which is applied in the direction of medical preparations containing active ingredients, organic chemistry, preparations for in vivo experiments, etc., can solve the problem of low toxic and side effects, achieve small toxic and side effects, improve therapeutic effect, The effect of preventing toxic side effects and tumor drug resistance

Active Publication Date: 2018-11-23
NANJING UNIV OF POSTS & TELECOMM
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  • Abstract
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Problems solved by technology

[0006] Traditional tumor treatment methods are usually accompanied by various toxic and side effects during the treatment process, and the development of new therapeutic methods with good curative effect and low toxic and side effects has attracted widespread attention

Method used

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  • Preparation and application of novel near-infrared two-zone organic small-molecule fluorescent probe
  • Preparation and application of novel near-infrared two-zone organic small-molecule fluorescent probe
  • Preparation and application of novel near-infrared two-zone organic small-molecule fluorescent probe

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Embodiment Construction

[0041] The present invention will be specifically introduced below in conjunction with the accompanying drawings and specific embodiments.

[0042] The reagents used in the embodiments of the present invention are all commercially available, and the instruments used include:

[0043] Near-infrared two-window fluorescence imager: NIRvana 640-Princeton instrument;

[0044] Photoacoustic imager: Endra Nexus 128;

[0045] Infrared thermal imager: TESTO869;

[0046] Laser: MDL-IH-730-1.5W-PSU-II-LED;

[0047] The abbreviations of the names of some chemical reagents are:

[0048] DSPE-PEG-FA: Phospholipid-polyethylene glycol-folate;

[0049] F127: Poloxamer is a polyoxyethylene polyoxypropylene ether block copolymer.

[0050] R in the embodiment of the present invention is For example:

[0051] 1. The synthetic route of DPP-BT-R2:

[0052]

[0053]

[0054] Concrete synthetic steps are as follows:

[0055]

[0056] A1, compound BT-R2: use 7-bromo-4-formylbenzo[c][...

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Abstract

The invention discloses a novel near-infrared two-zone organic small-molecule fluorescent probe and includes a concrete structure, a preparation and application. The main component of the novel near-infrared two-zone organic small-molecule fluorescent probe is a diketopyrrolopyrrole (DPP) derivative; and nano-particles with good water solubility, biocompatibility and targeting are prepared furtherwith a nanometer coprecipitation method, have excellent near-infrared two-zone fluorescence imaging and photoacoustic imaging abilities as well as photodynamic and photothermal conversion propertiesand can be used for tumor targeted photothermal and photodynamic combination therapy under the guidance of near-infrared two-zone fluorescence imaging, photoacoustic imaging, so that the therapeutic effect is remarkably improved; in addition, based on photodynamics therapy (PDT) and photothermal therapy (PTT), the toxic and side effects and the tumor drug resistance to normal tissues can be prevented and lowered; and the novel near-infrared two-zone organic small-molecule fluorescent probe is excellent in imaging effect, small in toxic and side effects and remarkable in curative effect and hasa relatively good clinical application prospect as a novel imaging probe and a tumor targeted combination therapy reagent.

Description

technical field [0001] The invention relates to a small-molecule fluorescent probe, in particular to the preparation and application of a novel near-infrared second-zone organic small-molecule fluorescent probe, and belongs to the technical field of biomedical engineering. Background technique [0002] Cancer has become one of the major diseases that threaten human life, so it is of great significance to develop new and effective diagnostic reagents for the diagnosis and treatment of tumors. [0003] Compared with common imaging techniques such as magnetic resonance imaging, tomographic imaging, and X-ray imaging, fluorescence imaging is widely used in the fields of biotechnology and life sciences due to its non-invasive, real-time, and high-resolution advantages. [0004] In recent years, near-infrared II region (NIR-II, 1000-1700nm) fluorescence imaging technology has received widespread attention. Due to the long emission wavelength of this band, the light scattering and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D487/04C09K11/06A61K41/00A61K49/22A61K49/00A61P35/00
CPCA61K41/0052A61K41/0057A61K49/0021A61K49/225A61P35/00C07D487/04C09K11/06C09K2211/1007C09K2211/1014C09K2211/1029C09K2211/1051C09K2211/1092A61K2300/00
Inventor 范曲立王其徐敬增夏兵陆峰黄维
Owner NANJING UNIV OF POSTS & TELECOMM
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